49ers vs. Steelers Odds and Betting Prediction for NFL Week 1

49ers vs. Steelers Odds and Betting Prediction for NFL Week 1

The San Francisco 49ers start their quest for the Super Bowl on Sunday when quarterback Brock Purdy leads the Niners to Acrisure Stadium in Pittsburgh to take on the Steelers. On paper, San Francisco looks like an easy SU and ATS winner. But the betting spread line hasn’t moved from San Fran -2.5.

Will the 49ers show why many believe they’re the team to beat this season to win the Super Bowl? Or will the Steelers pick it up at home and hand SF a loss?

Keep reading for NFL Odds Week 1, analysis, and a free pick for San Francisco at Pittsburgh.


49ers vs. Steelers Odds and Betting Prediction for the Game | MyBookie NFL Week 1 Regular Season Preview

San Francisco 49ers vs. Pittsburgh Steelers | NFL Week 1
ATS Odds: San Francisco -2.5
Money line Odds: Pittsburgh +101 / San Francisco -131  
Over/Under Odds: 41.5

Sunday, September 10th, 2023 at 1:00 PM | FOX
Acrisure Stadium, Pittsburgh, PA


Why Bet on San Francisco versus Pittsburgh?

Kyle Shannahan made Purdy the starting quarterback over both Trey Lance and Sam Darnold. The reason Shannahan did was because he believes Brock gives the Niners the best chance of winning the Super Bowl.

If Purdy is one-hundred percent healed from the elbow issue he suffered in the 2022 NFC Championship, SF’s offense should be difficult to contain. Pittsburgh has a good defense, but the 49ers boast Deebo Samuel and Christian McCaffrey, two of the top skill players in the league.

2022 San Francisco 49ers Offensive Averages

  • Total Yards: 377.0
  • Passing Yards: 226.8
  • Rushing Yards: 138.8
  • Points Scored: 26.5
  • 3rd Down %: 45.02

2022 San Francisco 49ers Defensive Averages

  • Total Yards: 318.6
  • Passing Yards: 222.9
  • Rushing Yards: 77.7
  • Points Scored: 16.3
  • 3rd Down %: 38.99

Why Bet on Pittsburgh versus San Francisco?

Pittsburgh fans should be encouraged that the line hasn’t moved. No line movement means NFL handicappers are seriously thinking of backing the Steelers against the spread or possibly even straight up.

Mike Tomlin’s defense will do a decent job against Purdy and the SF offense. The Steelers’ offense should be better than it has been in a while because Kenny Pickett has a season starting under his belt.

2022 Pittsburgh Steelers Offensive Averages

  • Total Yards: 337.3
  • Passing Yards: 200.6
  • Rushing Yards: 121.9
  • Points Scored: 18.1
  • 3rd Down %: 44.92

2022 Pittsburgh Steelers Defensive Averages

  • Total Yards: 347.3
  • Passing Yards: 222.3
  • Rushing Yards: 108.1
  • Points Scored: 20.4
  • 3rd Down %: 39.35

San Francisco 49ers at Pittsburgh Steelers Final Betting Prediction

Pittsburgh ended the regular season playing excellent football. The Steelers went 3-1 against the spread. But although Pittsburgh will play this game tough, it’s difficult seeing the AFC squad winning this matchup or keeping it closer than a 3 point loss.

San Francisco made it to the NFC Championship while going through three different quarterbacks. This season, Shanahan is sticking with Purdy and playing Darnold if he must.

The confidence in Brock speaks volumes. The 49ers also recently extended Nick Bosa. So SF’s defense is also set. San Francisco wins and covers at -2.5 but, again, this will be close. So if the line goes to 3 consider backing Pittsburgh ATS.  

NFL Week 1 Early Afternoon Pick: San Francisco 49ers -2.5 | Bet 49ers vs. Steelers
MyBookie Betting Lines for the Game


San Francisco 49ers Last 5

Date OPP Result
8/25/23 vs LAC L24-0
8/19/23 vs DEN W27-15
8/13/23 @ LV L27-17
1/29/23 @ PHI L28-14
1/22/23 vs DAL W16-13

San Francisco 49ers Injury Report

Name | Position Status DATE
George Kittle TE Questionable Sep y
Charvarius Ward CB Questionable Sep 7
Jake Moody PK Questionable Sep 7
Jordan Mason RB Questionable Sep 7
Ray-Ray McCloud III WR Questionable Sep 7

Pittsburgh Steelers Last 5

Date OPP Result
8/24/23 @ ATL W24-0
8/19/23 vs BUF W27-15
8/11/23 @ TB W27-17
1/8/23 vs CLE W28-14
1/1/23 @ BAL W16-13

Pittsburgh Steelers Injury Report

Name | Position Status DATE
Larry Ogunjobi DT Questionable Sep 6
Cameron Heyward DT Questionable Sep 7

San Francisco at Pittsburgh Betting Trends

  • The total has gone over in 5 of the last 5 versus Pittsburgh on the road
  • San Francisco is 12-1 SU in their last 13 games
  • Pittsburgh is 6-1 ATS in their last 7 games
  • The Steelers are 12-of-20 SU in their last 20
  • Pittsburgh is 3-1 ATS in their last 4 regular season games
  • The 49ers are 9-2 ATS in their last 11 games


The following NFL betting odds are based on MyBookie Sportsbook.

NFL Odds to Win this Season

Teams Odds
San Francisco 49ers +300
Kansas City Chiefs +510
Philadelphia Eagles +530
Baltimore Ravens +650
Miami Dolphins +730
Dallas Cowboys +830
Jacksonville Jaguars +1300
Detroit Lions +1450
Buffalo Bills +3700
Houston Texans +4400
Atlanta Falcons +7500
Green Bay Packers +7500
Cleveland Browns +7500
Pittsburgh Steelers +8000
Los Angeles Rams +8500
Indianapolis Colts +8500
Seattle Seahawks +8500
Denver Broncos +10000
Minnesota Vikings +11000
New Orleans Saints +12000
Los Angeles Chargers +14000
Tampa Bay Buccaneers +16000
Cincinnati Bengals +28000
Las Vegas Raiders +40000
New York Jets +55000
Chicago Bears +65000
Washington Commanders +70000
Tennessee Titans +75000
New York Giants +85000
New England Patriots +125000
Arizona Cardinals +125000
Carolina Panthers +150000

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