NFL Week 1 starts on Thursday when the Detroit Lions take on the Kansas City Chiefs. Both teams are favorites to win their respective divisions, which means we should be in for a show. Then on Sunday, the league kicks it up a notch when most teams play before Monday’s massive AFC East matchup between the New York Jets and the Buffalo Bills.
With the help of MyBookie’s expert, the NFL O/U picks should give you have a great chance to cash in NFL Week 1. Now, let’s get started.
NFL Week 1 Over/Under Betting Picks | MyBookie Regular Season Preview
2023-24 NFL | 104th season of the National Football League
Regular Season: September 7, 2023 – January 7, 2024
Detroit Lions at Kansas City Chiefs | Thursday Night Football
O/U Total: 54
Thursday, September 7th, 2023 | NBC
GEHA Field at Arrowhead Stadium, Kansas City, MO
Neither squad boasts a shut down defense, which is why oddsmakers have set such a massive over under total. The Chiefs, because this happens on their field, should post 30.
But so should the Lions because Chris Jones is out. Over is the play.
NFL Week 1 O/U Pick: Over | Bet Lions at Chiefs
MyBookie Betting Lines for the Total
Carolina Panthers at Atlanta Falcons
O/U Total: 40
Sunday, September 10th, 2023 at 1:00 pm | FOX
Mercedes-Benz Stadium, Atlanta, GA
Atlanta will lean on the rushing attack. The Falcons won’t push the envelope by throwing the ball too much. Not with Bijan Robinson in the backfield.
Carolina’s offense shouldn’t be effective in the first game. Not only is Bryce Young a rookie QB but he plays behind a suspect offensive line.
NFL Week 1 O/U Pick: Under | Bet Panthers at Falcons
MyBookie Betting Lines for the Total
Cincinnati Bengals at Cleveland Browns
O/U Total: 48
Sunday, September 10th, 2023 at 1:00 pm | CBS
Lucas Oil Stadium, Indianapolis, IN
Although listed as questionable, Joe Burrow should play. But just because Burrow projects to play, it doesn’t mean this goes over.
We have to question whether Deshaun Watson ever returns to his best form. Watson didn’t play well last season. Go under to cash.
NFL Week 1 O/U Pick: Under | Bet Bengals at Browns
MyBookie Betting Lines for the Total
Jacksonville Jaguars at Indianapolis Colts
O/U Total: 41
Sunday, September 10th, 2023 at 1:00 pm | FOX
Lucas Oil Stadium, Indianapolis, IN
Jacksonville’s offense should be very difficult to contain. The Colts have a decent defense, but Trevor Lawrence projects to take the next step.
Indianapolis will struggle to move the football against a solid Jaguars’ defense, though. Anthony Richardson is a rookie while the Jags’ D has the makings of a special unit. Here’s another that should go under.
NFL Week 1 O/U Pick: Under | Bet Jaguars at Colts
MyBookie Betting Lines for the Total
Tampa Bay Buccaneers at Minnesota Vikings
O/U Total: 45.5
Sunday, September 10th, 2023 at 1:00 pm | CBS
U.S. Bank Stadium, Minneapolis, MN
Both offenses should excel. Kirk Cousins and Justin Jefferson should play well against an aging Tampa defense.
On the other side of the field, Baker Mayfield will get Tampa’s offense going early versus a bad Minnesota defense. Over is the play.
NFL Week 1 O/U Pick: Over | Bet Buccaneers at Vikings
MyBookie Betting Lines for the Total
Tennessee Titans at New Orleans Saints
O/U Total: 41
Sunday, September 10th, 2023 at 1:00 pm | CBS
Caesars Superdome, New Orleans, LA
The total in this game is much too low. The Titans’ defense is terrible against the pass while the Saints should have one of the better passing attacks in the NFL now that Michael Thomas is healthy and Derek Carr is the quarterback.
Tennessee QB Ryan Tannehill gets to throw to DeAndre Hopkins. Going over makes sense.
NFL Week 1 O/U Pick: Over | Bet Titans at Saints
MyBookie Betting Lines for the Total
San Francisco 49ers at Pittsburgh Steelers
O/U Total: 41
Sunday, September 10th, 2023 at 1:00 pm | FOX
Acrisure Stadium, Pittsburgh, PA
The total feels low but that’s only because San Francisco should move the football and score a few touchdowns.
However, Pittsburgh’s offense will want to establish the run, take their time, and keep the ball from Brock Purdy and the 49ers. This could turn into the type of game where the Niners win something like 23-10
NFL Week 1 O/U Pick: Under | Bet 49ers at Steelers
MyBookie Betting Lines for the Total
Arizona Cardinals at Washington Commanders
O/U Total: 38.5
Sunday, September 10th, 2023 at 1:00 pm | FOX
M&T Bank Stadium, Baltimore, MD
It doesn’t matter if the Cardinals start Joshua Dobbs or rookie Clayton Tune. The Cards’ quarterback faces the best defensive line in the NFL.
Washington should win this via blowout, which means the score goes under because by blowout, we’re talking 17-3.
NFL Week 1 O/U Pick: Under | Bet Cardinals at Commanders
MyBookie Betting Lines for the Total
Houston Texans at Baltimore Ravens
O/U Total: 43.5
Sunday, September 10th, 2023 at 1:00 pm | CBS
M&T Bank Stadium, Baltimore, MD
Baltimore could shut out the Houton Texans. The Ravens played great defense last season. This season, Baltimore should have a better offense, but even if that’s the case, Houston’s D isn’t bad. Let’s say the Ravens win 24-0.
NFL Week 1 O/U Pick: Under | Bet Texans at Ravens
MyBookie Betting Lines for the Total
Green Bay Packers at Chicago Bears
O/U Total: 43.5
Sunday, September 10th, 2023 at 4:25 pm | CBS
Empower Field at Mile High, Denver, CO
The total in this one doesn’t make much sense. The Chicago Bears are going to have a dynamic offense. Justin Fields is already one of the top rushing quarterbacks in the league.
Expect the Bears to have thrown in a few of Philly’s plays, meaning Chicago utilize Justin the way the Eagles utilize Jalen Hurts.
Green Bay’s Jordan Love won’t make Packer fans forget about Aaron Rodgers, but he will find success against a bad Bears’ D. Over for sure.
NFL Week 1 O/U Pick: Over | Bet Packers at Bears
MyBookie Betting Lines for the Total
Las Vegas Raiders at Denver Broncos
O/U Total: 44
Sunday, September 10th, 2023 at 4:25 pm | CBS
Empower Field at Mile High, Denver, CO
Sean Payton is going to want to make a statement, which means the Broncos might get the over by themselves on Sunday.
NFL Week 1 O/U Pick: Over | Bet Raiders at Broncos
MyBookie Betting Lines for the Total
Philadelphi Eagles at New England Patriots
O/U Total: 45
Sunday, September 10th, 2023 at 4:25 pm | CBS
Gillette Stadium, Foxborough, MA
Hurts and the Eagles can move the ball at will but New England may not give up many touchdowns.
Bill Belichick will play bend but don’t break. Then when he has the ball, Bill O’Brien will run schemes that allows New England to keep the ball for long stretches.
NFL Week 1 O/U Pick: Under | Bet Eagles at Patriots
MyBookie Betting Lines for the Total
Miami Dolphins at Los Angeles Chargers
O/U Total: 51
Sunday, September 10th, 2023 at 4:25 pm | CBS
SoFi Stadium, Inglewood, CA
51? What is this? Oregon versus Washington in the now defunct Pac-12?
51 is a massive total. But this goes over. The Dolphins play fast. The Chargers will have no choice but to counter.
NFL Week 1 O/U Pick: Over | Bet Dolphins at Chargers
MyBookie Betting Lines for the Total
Los Angeles Rams at Seattle Seahawks
O/U Total: 46.5
Sunday, September 10th, 2023 at 4:25 pm | FOX
Lumen Field, Seattle, WA
This is an under game. Seattle resigned one of the best linebackers in franchise history in Bobby Wagner.
Wagner is a run stopper and the Rams’ offensive line is a disaster. Seattle could get the over by themselves but we must assume Pete Carroll dials it back after getting up by 3 touchdowns.
NFL Week 1 O/U Pick: Under | Bet Rams at Seahawks
MyBookie Betting Lines for the Total
Dallas Cowboys at New York Giants | Sunday Night Football
O/U Total: 46.5
Sunday, September 10th, 2023 at 8:20 pm | FOX
MetLife Stadium, East Rutherford, NJ
Even though both teams have great offenses, this feels like an under game. The Cowboys are on the road and Dallas’ offense likely won’t be as effective versus a rival on the road in their first game as it will be later in the season.
The Giants won’t play slow. But Brian Daboll is a master of game pace. Under is the play.
NFL Week 1 O/U Pick: Under | Bet Cowboys at Giants
MyBookie Betting Lines for the Total
Buffalo Bills at New York Jets | Monday Night Football
O/U Total: 46.5
Thursday, September 7, 2023 | NBC
MetLife Stadium, East Rutherford, NJ
Buffalo’s defense ranked second in points allowed per game last season. Sure, Aaron Rodgers is the Jets quarterback but AR may require a game or two to get himself into AFC mode.
Also, the J-E-T-S D knows how to defend against Josh Allen and the Bills’ offense. The NFL Week 1 Monday night game goes under.
NFL Week 1 O/U Pick: Under | Bet Bills at Jets
MyBookie Betting Lines for the Total
NFL Week 1 Schedule
Dates: 9/7 – 9/11
BYE WEEK: No teams on bye
Date | Spread | Moneyline | Over Under |
---|---|---|---|
Thu, Sept. 7 | Lions at Chiefs (-7) | Lions +232; Chiefs -300 | 54 |
Sun, Sept. 10 |
Texans at Ravens (-9.5) | Texans +330; Ravens -450 |
44.5 |
Sun, Sept. 10 |
Buccaneers at Vikings (-6.5) | Buccaneers +235; Vikings -300 |
45.5 |
Sun, Sept. 10 |
Bengals (-2.5) at Browns | Bengals -136; Browns +111 |
47 |
Sun, Sept. 10 |
Jaguars (-3) at Colts | Jaguars -172; Colts +140 | 43.5 |
Sun, Sept. 10 |
49ers (-3) at Steelers | 49ers -160; Steelers +130 | 40.5 |
Sun, Sept. 10 |
Cardinals at Commanders (-5.5) | Cardinals +204; Commanders -259 | 40.5 |
Sun, Sept. 10 |
Titans at Saints (-3.5) | Titans +150; Saints -185 | 41.5 |
Sun, Sept. 10 |
Panthers at Falcons (-3) | Panthers +132; Falcons -162 | 42.5 |
Sun, Sept. 10 |
Eagles (-4.5) at Patriots | Eagles -204; Patriots +164 | 45 |
Sun, Sept. 10 |
Dolphins at Chargers (-2.5) | Dolphins +115; Chargers -141 | 50 |
Sun, Sept. 10 |
Packers at Bears (-2.5) | Packers +114; Bears -139 | 44 |
Sun, Sept. 10 |
Rams at Seahawks (-5) | Rams +185; Seahawks -232 | 47 |
Sun, Sept. 10 |
Raiders at Broncos (-3.5) | Raiders +157; Broncos -194 | 44.5 |
Sun, Sept. 10 |
Cowboys (-3) at Giants | Cowboys -168; Giants +136 | 46.5 |
Mon, Sept. 11 |
Bills (-1.5) at Jets | Bills -121; Jets +100 | 47 |
NFL Week Two >>
The following NFL betting odds are based on MyBookie Sportsbook.
Super Bowl Odds to Win this 2025 NFL Season
The following NFL betting lines are based on MyBookie Sportsbook.
Teams | Odds |
---|---|
San Francisco 49ers | +550 |
Kansas City Chiefs | +700 |
Baltimore Ravens | +800 |
Buffalo Bills | +1000 |
Detroit Lions+1200 | |
Cincinnati Bengals | +1300 |
Dallas Cowboys | +1600 |
Philadelphia Eagles | +1800 |
Miami Dolphins | +2000 |
Green Bay Packers | +2200 |
Houston Texans | +2200 |
LA Chargers | +2500 |
New York Jets | +2500 |
Jacksonville Jaguars | +3500 |
Los Angeles Rams | +3500 |
Cleveland Browns | +4000 |
Minnesota Vikings | +4000 |
Atlanta Falcons | +5000 |
Chicago Bears | +5000 |
Indianapolis Colts | +5000 |
Denver Broncos | +7500 |
Las Vegas Raiders | +7500 |
New Orleans Saints | +7500 |
Pittsburgh Steelers | +7500 |
Seattle Seahawks | +7500 |
Tampa Bay Buccaneers | +7500 |
Arizona Cardinals | +10000 |
New England Patriots | +15000 |
New York Giants | +15000 |
Tennessee Titans | +15000 |
Washington Commanders | +15000 |
Carolina Panthers | +25000 |
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