49ers vs. Steelers Odds and Betting Prediction for NFL Week 1

49ers vs. Steelers Odds and Betting Prediction for NFL Week 1

The San Francisco 49ers start their quest for the Super Bowl on Sunday when quarterback Brock Purdy leads the Niners to Acrisure Stadium in Pittsburgh to take on the Steelers. On paper, San Francisco looks like an easy SU and ATS winner. But the betting spread line hasn’t moved from San Fran -2.5.

Will the 49ers show why many believe they’re the team to beat this season to win the Super Bowl? Or will the Steelers pick it up at home and hand SF a loss?

Keep reading for NFL Odds Week 1, analysis, and a free pick for San Francisco at Pittsburgh.


49ers vs. Steelers Odds and Betting Prediction for the Game | MyBookie NFL Week 1 Regular Season Preview

San Francisco 49ers vs. Pittsburgh Steelers | NFL Week 1
ATS Odds: San Francisco -2.5
Money line Odds: Pittsburgh +101 / San Francisco -131  
Over/Under Odds: 41.5

Sunday, September 10th, 2023 at 1:00 PM | FOX
Acrisure Stadium, Pittsburgh, PA


Why Bet on San Francisco versus Pittsburgh?

Kyle Shannahan made Purdy the starting quarterback over both Trey Lance and Sam Darnold. The reason Shannahan did was because he believes Brock gives the Niners the best chance of winning the Super Bowl.

If Purdy is one-hundred percent healed from the elbow issue he suffered in the 2022 NFC Championship, SF’s offense should be difficult to contain. Pittsburgh has a good defense, but the 49ers boast Deebo Samuel and Christian McCaffrey, two of the top skill players in the league.

2022 San Francisco 49ers Offensive Averages

  • Total Yards: 377.0
  • Passing Yards: 226.8
  • Rushing Yards: 138.8
  • Points Scored: 26.5
  • 3rd Down %: 45.02

2022 San Francisco 49ers Defensive Averages

  • Total Yards: 318.6
  • Passing Yards: 222.9
  • Rushing Yards: 77.7
  • Points Scored: 16.3
  • 3rd Down %: 38.99

Why Bet on Pittsburgh versus San Francisco?

Pittsburgh fans should be encouraged that the line hasn’t moved. No line movement means NFL handicappers are seriously thinking of backing the Steelers against the spread or possibly even straight up.

Mike Tomlin’s defense will do a decent job against Purdy and the SF offense. The Steelers’ offense should be better than it has been in a while because Kenny Pickett has a season starting under his belt.

2022 Pittsburgh Steelers Offensive Averages

  • Total Yards: 337.3
  • Passing Yards: 200.6
  • Rushing Yards: 121.9
  • Points Scored: 18.1
  • 3rd Down %: 44.92

2022 Pittsburgh Steelers Defensive Averages

  • Total Yards: 347.3
  • Passing Yards: 222.3
  • Rushing Yards: 108.1
  • Points Scored: 20.4
  • 3rd Down %: 39.35

San Francisco 49ers at Pittsburgh Steelers Final Betting Prediction

Pittsburgh ended the regular season playing excellent football. The Steelers went 3-1 against the spread. But although Pittsburgh will play this game tough, it’s difficult seeing the AFC squad winning this matchup or keeping it closer than a 3 point loss.

San Francisco made it to the NFC Championship while going through three different quarterbacks. This season, Shanahan is sticking with Purdy and playing Darnold if he must.

The confidence in Brock speaks volumes. The 49ers also recently extended Nick Bosa. So SF’s defense is also set. San Francisco wins and covers at -2.5 but, again, this will be close. So if the line goes to 3 consider backing Pittsburgh ATS.  

NFL Week 1 Early Afternoon Pick: San Francisco 49ers -2.5 | Bet 49ers vs. Steelers
MyBookie Betting Lines for the Game


San Francisco 49ers Last 5

8/25/23vs LACL24-0
8/19/23vs DENW27-15
8/13/23@ LVL27-17
1/29/23@ PHIL28-14
1/22/23vs DALW16-13

San Francisco 49ers Injury Report

Name | PositionStatus DATE
George Kittle TEQuestionableSep y
Charvarius Ward CBQuestionableSep 7
Jake MoodyPKQuestionableSep 7
Jordan Mason RBQuestionableSep 7
Ray-Ray McCloud III WRQuestionableSep 7

Pittsburgh Steelers Last 5

8/24/23@ ATLW24-0
8/19/23vs BUFW27-15
8/11/23@ TBW27-17
1/8/23vs CLEW28-14
1/1/23@ BALW16-13

Pittsburgh Steelers Injury Report

Name | PositionStatus DATE
Larry Ogunjobi DTQuestionableSep 6
Cameron Heyward DTQuestionableSep 7

San Francisco at Pittsburgh Betting Trends

  • The total has gone over in 5 of the last 5 versus Pittsburgh on the road
  • San Francisco is 12-1 SU in their last 13 games
  • Pittsburgh is 6-1 ATS in their last 7 games
  • The Steelers are 12-of-20 SU in their last 20
  • Pittsburgh is 3-1 ATS in their last 4 regular season games
  • The 49ers are 9-2 ATS in their last 11 games


The following NFL betting odds are based on MyBookie Sportsbook.


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