Bills at 49ers: December 7, 2020 Odds and Computer Picks for Monday Night Football

Written by on December 7, 2020

Oddsmakers project a tight game when the Buffalo Bills (8-3) take on the San Francisco 49ers (5-6) as just 2.5-point favorites on Monday, December 7, 2020. An over/under of 48.5 is set for the game.

Game Info

  • Game Day: Monday, December 7, 2020
  • Game Time: 8:15 PM ET
  • TV Channel: ESPN
  • Location: Glendale, AZ
  • Stadium: State Farm Stadium
Click here to place a bet on the Bills or the 49ers in their matchup on 12/7/2020.

Betting Information

Bills vs 49ers Betting Information
Favorite Spread Favorite Spread Odds Underdog Spread Odds Total Over Total Odds Under Total Odds Favorite Moneyline Underdog Moneyline
Bills -2.5 -125 105 48.5 -110 -110 N/A N/A

Bills Betting Insights

  • Most of Buffalo’s games this year — eight out of 11 — have hit the over (72.7%).
  • Buffalo is 6-5 against the spread.
  • The Bills are just 3-4 ATS when playing as at least 2.5-point favorites.
  • The Bills have put an average of 27.2 points per game on the scoreboard this season, 4.1 more than the 23.1 the 49ers have surrendered in each contest.
  • When they meet or outpace their scoring average this season, Buffalo is 4-1 and 4-1 against the spread.
  • San Francisco is 5-0 overall and 5-0 against the spread this season in games where they allow fewer than 23.1 points.
Click here to bet on the Bills to win the Super Bowl

49ers Betting Insights

  • Most of San Francisco’s games this year — six out of 11 — have failed to go over the point total (54.5%).
  • San Francisco has put together a losing 5-6 record against the spread this season.
  • The 49ers have a losing ATS record of 2-3 when playing as at least 2.5-point underdogs.
  • The 49ers average points scored this season (23.7) and the Bills points allowed (25.6) are within 1.9 points of each other.
  • In games where San Francisco scores at least 23.7 points this season, they are 4-1 overall and 4-1 against the spread.
  • When Buffalo allows opposing offenses to put 25.6 points or fewer on the scoreboard this year, they are 5-0 overall and 3-2 against the spread.
Click here to bet on the 49ers to win the Super Bowl

Computer Picks

Computer picks for Bills vs 49ers
ATS Over/Under Score Prediction
49ers (+2.5) Over (48.5) 49ers 26 Bills 24

Total Facts

  • The Bills and their opponents have scored at least 48.5 points — this matchup’s point total — in six of 11 games (54.5%) this season.
  • San Francisco and its opponents have combined to score at least 48.5 points in 27.3% of their matchups this season (three of 11 chances).
  • The Bills and the 49ers combine to average 2.4 more points per game than the total of 48.5 set for this game.
  • Opponents of these teams have averaged a combined 48.7 points per game, 0.2 more than the over/under for this game.
  • The average total the Bills have had set in matchups this year is 4.3 more points than this outing’s point total.
  • The average point total for the 49ers this season is 1.7 points lower than this game’s over/under.
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Bills vs 49ers: Last 5 Meetings

San Francisco has an edge against Buffalo in the last five meetings between these two squads, putting together a 3-2 record in those games. San Francisco has had the scoring advantage in those five matchups, recording 113 points while Buffalo scored 92.

Bills vs 49ers: Last Five Meetings
Date Home Team Total Yards Result
10/16/2016 Bills 492-300 BUF 45-16 BUF
10/7/2012 49ers 621-204 SF 45-3 SF
11/30/2008 Bills 10-3 SF
12/26/2004 49ers 41-7 BUF
12/2/2001 49ers 35-0 SF

Betting Insights: Last Three Games (Both Teams)

  • The Bills and their opponents have combined to score an average of 61.3 points in their last three games, 12.8 more than the 48.5 over/under in this matchup.
  • Buffalo is 3-0 against the spread and 2-1 straight up over the last three contests.
  • Buffalo has hit the over two times in the last three contests.
  • The 49ers have averaged a total of 44.7 combined points in their last three games, 3.8 fewer than this matchup’s over/under of 48.5.
  • San Francisco is just 1-2 against the spread and 1-2 straight up over their last three contests.
  • San Francisco has gone under the total two times in their last three games.

Injury Report

Bills: No Injuries Listed

49ers: No Injuries Listed


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