New England Patriots vs. San Francisco 49ers: Odds and Computer Picks October 25, 2020

Written by on October 25, 2020

The San Francisco 49ers (3-3) are just 2.5-point underdogs against the New England Patriots (2-3) on Sunday, October 25, 2020. The over/under is set at 45.5.

Game Info

  • Game Day: Sunday, October 25, 2020
  • Game Time: 4:25 PM ET
  • TV Channel: CBS
  • Location: Foxborough, MA
  • Stadium: Gillette Stadium
Click here to place a bet on the Patriots or the 49ers in their matchup on 10/25/2020.

Betting Information

Patriots vs 49ers Betting Information
Favorite Spread Favorite Spread Odds Underdog Spread Odds Total Over Total Odds Under Total Odds Favorite Moneyline Underdog Moneyline
Patriots -2.5 -115 -105 45.5 -110 -110 -143 123

Patriots Betting Insights

  • New England’s games have gone under the point total in three out of five opportunities this season (60%).
  • New England is just 2-3 against the spread.
  • The Patriots are 2-1 ATS when favored by at least 2.5 points.
  • The 49ers defense has allowed 21.7 points per game this season, about the same amount as the 21.8 the Patriots have scored.
  • In games where New England score at least 21.8 points this season, they are 1-1 overall and 1-1 against the spread.
  • When the San Francisco defense allows 21.7 points or fewer this year, the 49ers have pieced together a 3-0 overall record and a 3-0 record against the spread.
Click here to bet on the Patriots to win the Super Bowl

49ers Betting Insights

  • Half of San Francisco’s games this year — three out of six — have gone over the point total.
  • San Francisco is 3-3 against the spread.
  • The 49ers are just 2-3 ATS when an underdog by at least 2.5 points.
  • The Patriots defense has allowed 22 points per game this season, close to the same amount as the 24.7 the 49ers have scored.
  • San Francisco is 2-0 overall and 2-0 against the spread when they score at least 24.7 points this season.
  • When New England allows opposing offenses to put 22 points or fewer on the scoreboard this year, they are 2-1 overall and 2-1 against the spread.
Click here to bet on the 49ers to win the Super Bowl

Computer Picks

Computer picks for Patriots vs 49ers
ATS Over/Under Score Prediction
Patriots (-2.5) Under (45.5) Patriots 28 49ers 17

Total Facts

  • The Patriots’ average point total in outings this season is 43.8, 1.7 points below the over/under in this game.
  • The average point total for the 49ers this year is 0.8 points higher than this game’s over/under.
  • The Patriots and their opponents have combined to record more than this matchup’s over/under (45.5 points) in 40% of their games this season (two of five opportunities).
  • The 49ers have played in one games this year (out of six total matchups — 16.7% of opportunities) where they and their opponents combined to score at least 45.5 points.
  • The Patriots and the 49ers combine to average 1.0 more points per game than the total of 45.5 set for this game.
  • Opponents of the two teams average a combined 1.8 less points per game (43.7) than this game’s over/under of 45.5 points.
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Patriots vs 49ers: Last 5 Meetings

New England holds an edge against San Francisco over the past five matchups between these two squads, collecting a 4-1 record in those games. New England has had the scoring advantage in those five matchups, scoring 139 points while San Francisco put up 107.

Patriots vs 49ers: Last Five Meetings
Date Home Team Total Yards Result
11/20/2016 49ers 444-299 NE 30-17 NE
12/16/2012 Patriots 520-388 NE 41-34 SF
10/5/2008 49ers 30-21 NE
1/2/2005 Patriots 21-7 NE
12/20/1998 Patriots 24-21 NE

Betting Insights: Last Three Games (Both Teams)

  • New England is just 1-2 against the spread and 1-2 straight up in their last three outcomes.
  • The under has been the norm for New England. They have failed to reach the total two times in their last three games.
  • The Patriots have averaged a total of 40.7 combined points over their last three games, 4.8 less than this game’s total of 45.5.
  • San Francisco has struggled to cover recently, going 1-2 against the spread and 1-2 straight up over their last three contests.
  • The under has been the norm for San Francisco. They have failed to reach the total two times in their last three games.
  • The 49ers have averaged a total of 48.3 combined points in their last three games, 2.8 greater than this game’s over/under of 45.5.

Injury Report

Patriots: FS Cody Davis: Out (Ribs), DT Beau Allen: Out (Undisclosed), G James Ferentz: Out (Illness), G Shaq Mason: Out (Illness), LB Brandon King: Out (Quadriceps), C David Andrews: Out (Thumb), DE Derek Rivers: Out (Illness), G Jermaine Eluemunor: Questionable (Ankle), WR Quincy Adeboyejo: Out (Undisclosed), DT Adam Butler: Questionable (Elbow), RB Sony Michel: Out (Illness), OT Yodny Cajuste: Out (Knee), DT Byron Cowart: Out (Illness), LB Josh Uche: Out (Foot), DL Michael Barnett: Out (Undisclosed)

49ers: OT Trent Williams: Questionable (Ankle), CB Richard Sherman: Out (Leg), TE Jordan Reed: Out (Knee), DE Ziggy Ansah: Out (Biceps), WR Tavon Austin: Out (Knee), C Ben Garland: Questionable (Calf), CB K’Waun Williams: Out (Knee), DE Dee Ford: Out (Back), C Weston Richburg: Out (Kneecap), CB Dontae Johnson: Questionable (Groin), SS Jaquiski Tartt: Questionable (Groin), RB Tevin Coleman: Out (Knee), OLB Kwon Alexander: Questionable (Ankle), OLB Mark Nzeocha: Out (Quadriceps), RB Raheem Mostert: Questionable (Ankle), DE Ronald Blair III: Out (Knee), DT Solomon Thomas: Out (Knee (acl)), WR Chris Thompson: Out (Undisclosed), DT Jullian Taylor: Out (Knee), RB Jeff Wilson Jr.: Questionable (Calf), DE Nick Bosa: Out (Acl), WR Jalen Hurd: Out (Knee), TE Chase Harrell: Out (Suspension)


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