NFL Week 3 Odds Overview & Predictions for Each Game

NFL Week 3 Opening Odds Overview & Predictions for Each Game

Great games dot the NFL Week 3 schedule, including Saints at Patriots, Las Vegas hosting Miami, and a massive Sunday night matchup between the Green Bay Packers and San Francisco 49ers. Check out NFL odds along with analysis and free picks. 

NFL 2021 Regular Season Week 3 Odds Analysis & Picks

Week 3 of the 2021 NFL Regular Season

  • When: Thursday, Sep. 23 – Monday, Sep. 27

Carolina Panthers -7 ½ vs Houston Texans – Week 3 Spread

  • When: Thursday, Sep. 23

Carolina has won two in a row and heads into this off a massive win against the New Orleans Saints. On paper, it looks as if the Panthers should roll. If Texans quarterback Tyrod Taylor doesn’t play, they might. But if Taylor does step under center, Houston will have a shot to pull off the ATS upset. Right now, we think Taylor plays. 

NFL Week 3 Pick: Houston Texans  

Arizona Cardinals -7 ½ vs Jacksonville Jaguars – Week 3 Spread

  • When: Sunday, Sep. 26

This could be a big time trap game for the Arizona Cardinals. In week 1, the Cards defense did a number on the Titans. But in their second game, the Cards got lucky when Minnesota missed a last second field goal. Jacksonville has some offensive talent. Zona takes a backward step and ekes out another win. 

NFL Week 3 Pick: Jacksonville Jaguars 

Indianapolis Colts vs Tennessee Titans -5 – Week 3 Spread

  • When: Sunday, Sep. 26

Colts’ QB Carson Wentz sprained both his right and left ankles. Derrick Henry got it going against the Seahawks last week. There’s no reason to believe he doesn’t get it going versus the Colts. 

NFL Week 3 Pick: Tennessee Titans 

Washington Football Team vs Buffalo Bills -9 – Week 3

  • When: Sunday, Sep. 26

Taylor Heinicke tore it up against a solid Giants’ defense, throwing for 336 yards and a couple of TDs with a single pick. Buffalo dominated the Dolphins. They could regress in this. That doesn’t mean they lose, but the WFT defensive line can temper Josh Allen and the Bills’ explosive offense. So think a 6 to 7 point victory. 

NFL Week 3 Pick: Washington Football Team   

New Orleans Saints vs New England Patriots -3 – Week 3 Spread

  • When: Sunday, Sep. 26

Why did the Saints lose to the Carolina Panthers in NFL Week 2? Most believe its because of injuries, 7 coaches on the COVID list, the usual. The real reason, though, is because Sean Payton made some bad calls on offense and Jameis Winston, by his own admission, failed to communicate with the offensive line. If New Orleans fixes those issues this week, they can beat the Patriots on the moneyline. 

NFL Week 3 Pick: New Orleans Saints straight up   

Atlanta Falcons vs New York Giants -3 – Week 3 Spread

  • When: Sunday, Sep. 26

The Falcons played much better in week 2 than in week 1. Not only that, but the decent performance was against the defending champion Tampa Bay Buccaneers. Don’t be fooled, though. Atlanta is way worse than the Giants, who will be looking to make amends in this for a blown opportunity against the WFT.

NFL Week 3 Pick: New York Giants  

Chicago Bears vs Cleveland Browns -7 ½  – Week 3

  • When: Sunday, Sep. 26

The Bears have an issue in this game. Andy Dalton is listed as day-to-day and Justin Fields showed he’s not ready. The Browns should roll in this game. Baker and his mates have a real shot of blowing out Chicago

NFL Week 3 Pick: Cleveland Browns 

Baltimore Ravens -9 vs Detroit Lions – Week 3 Spread

  • When: Sunday, Sep. 26

It looks like the Ravens should easily cover this line. But let’s put things in perspective. Lamar Jackson and Baltimore got lucky in the sensational 36-35 victory versus KC. No doubt, the Edgar Allan Poes take a slight backward step in this. The Lions can cover.  

NFL Week 3 Pick: Detroit Lions  

Cincinnati Bengals vs Pittsburgh Steelers -4 ½  – Week 3 Spread

  • When: Sunday, Sep. 26

In the second week loss to the Las Vegas Raiders, Pittsburgh played with no energy and looked as if they were going through the motions. Facing a division rival, the Steelers’ defense should be on point. Joe Burrow rushed against Chicago, throwing 3 picks. This will be a close game, but the line should be closer to Steelers -5.5.

NFL Week 3 Pick: Pittsburgh Steelers  

Miami Dolphins vs Las Vegas Raiders -4 – Week 3 Spread

  • When: Sunday, Sep. 26

We’d usually play a team like Miami on the bounce back. But Tua might be out with bruised ribs. Even if he plays, there’s something different about this Raiders team. LV doesn’t panic. Instead, they execute. Las Vegas should cover this spread. 

NFL Week 3 Pick: Las Vegas Raiders  

New York Jets vs Denver Broncos -11 – Week 3 Spread

  • When: Sunday, Sep. 26

11 is a lot of points. However, the Jets remain a work in progress. Like the Raiders, the Broncos are executing like one of the best teams in the NFL. Denver’s defense is solid while Teddy Bridgewater doesn’t make mistakes. The Ponies roll.  

NFL Week 3 Pick: Denver Broncos 

Tampa Bay Buccaneers vs Los Angeles Rams PK – Week 3 v

  • When: Sunday, Sep. 26

Two of the best teams in the league throw down when the Buccaneers face off agianst the Rams. Tampa struggled some versus the Atlanta Falcons in their last. One of the reasons could be because in the back of their minds they knew they faced Matthew Stafford and LAR in NFL Week 3. The Rams are a good team. But they aren’t on Tampa’s level yet. TB wins this. 

NFL Week 3 Pick: Tampa Bay Buccaneers 

Seattle Seahawks -1 vs Minnesota Vikings – Week 3 Spread

  • When: Sunday, Sep. 26

The Seahawks rank 30th in total yards allowed per game. The Vikings almost pulled off the upset against the Cardinals. Minnesota’s offense can hang with Seattle’s, which means homefield advantage could come into play. The Norsemen should get their first victory of the season. 

NFL Week 3 Pick: Minnesota Vikings  

Green Bay Packers vs San Francisco 49ers -3.5 – Week 3 v

  • When: Sunday, Sep. 26

The Packers kicked it into gear in NFL Week 2, but it was against the Detroit Lions and at Lambeau Field. The 49ers covered versus a decent team, the Philadelphia Eagles, on the road. The half-a-point could be all the difference. The Pack covers. 

NFL Week 3 Pick: Green Bay Packers   

Philadelphia Eagles vs Dallas Cowboys -3 ½  – Week 3 Spread

  • When: Monday, Sep. 27

Dallas’ defense roughed up Justin Herbert. Jalen Hurts is a different quarterback, but the Eagles should struggle on the road versus a solid team like Dallas. Still, Philly’s D will keep them in this game. This will be close enough to warrant taking the points. 

NFL Week 3 Pick: Philadelphia Eagles


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