For the second straight week the Buffalo Bills play in the NFL’s marquee game. Josh Allen and the Bills take on Derrick Henry and the Tennessee Titans on Monday night football. But although Bills versus Titans is this week’s most intriguing matchup, we won’t have to wait long for football fireworks. On Thursday, the Eagles host the Buccaneers in a much closer game than many might believe. Keep reading for NFL odds, analysis, and free picks for Week 6 of the 2021 regular season!
2021 NFL Regular Season – Week 6 Odds Analysis & Picks
2021 NFL Week 6
- When: Thursday, Oct. 14 – Monday, Oct. 18
Tampa Bay Buccaneers -7 vs Philadelphia Eagles
- When: Thursday, Oct. 14
Tamp dominated the Miami Dolphins in week 5. But this is a road game and the Eagles are a decent team. Philly can keep this close.
NFL Week 6 Pick: Philadelphia Eagles
Miami Dolphins -3 ½ vs Jacksonville Jaguars
- When: Sunday, Oct. 17
Miami is a mess. So are the Jaguars. The bottom line in this one? The Dolphins should get back on track in a big way because they’ve got a better coaching staff and a much, much better defense.
NFL Week 6 Pick: Miami Dolphins
Houston Texans vs Indianapolis Colts -10
- When: Sunday, Oct. 17
On Monday night, the Colts played too good to lose. Indianapolis had a lead over the Baltimore Ravens. If not for Lamar’s heroics, the Colts would have pulled off the straight up victory. The Texans kept it close against the Patriots. They won’t against Indy.
NFL Week 6 Pick: Indianapolis Colts
Green Bay Packers -4 ½ vs Chicago Bears
- When: Sunday, Oct. 17
Bears versus Packers should be a great game. Green Bay has dominated a single team this season, the Detroit Lions. Justin Fields played great leading the Bears to an upset win against the Raiders. Bears can pull off the SU upset.
NFL Week 6 Pick: Chicago Bears moneyline
Kansas City Chiefs -6 ½ vs Washington Football Team
- When: Sunday, Oct. 17
Once again, oddsmakers are giving Kansas City too much credit. The defense is terrible. On Sunday, it faces an offense that averages 24.6 points per. The 6 ½ should mean something.
NFL Week 6 Pick: Washington Football Team
Minnesota Vikings vs Carolina Panthers -1 ½
- When: Sunday, Oct. 17
This could end up a quarterback duel. Minnesota’s QB, Kirk Cousins, is a better player than Carolina’s quarterback, Sam Darnold.
NFL Week 6 Pick: Minnesota Vikings
Los Angeles Chargers vs Baltimore Ravens -3 ½
- When: Sunday, Oct. 17
The Chargers are one of the best teams in the NFL. They should play great on Sunday against a Ravens squad that required overtime to beat the Colts on Monday night. The moneyline upset looks promising.
NFL Week 6 Pick: Los Angeles Chargers moneyline
Cincinnati Bengals -3 vs Detroit Lions
Will the Lions get their first win of the season? It’s not likely. If the Bengals hadn’t lost in overtime to the Packers in NFL Week 5, Cincinnati would be 4-1. Unless Joe Burrow doesn’t play, the Tigers should cover.
NFL Week 6 Pick: Cincinnati Bengals
Los Angeles Rams -10 ½ vs New York Giants
- When: Sunday, Oct. 17
Both Saquon Barkley and Daniel Jones suffered injuries in the devastating 44-20 loss to the Dallas Cowboys. 10 ½ is a lot of points to lay on a team that likes to take their time scoring points. But backing the Rams is the only play we can make knowing there’s a big chance Barkley and Jones miss this.
NFL Week 6 Pick: Los Angeles Rams
Arizona Cardinals vs Cleveland Browns -2 ½
- When: Sunday, Oct. 17
Arizona has played great football to get to 5-0. On Sunday, they lose their first game of the season. Baker Mayfield and the Cleveland Browns might be the best team the Cardinals have faced in 2021. Browns win and cover.
NFL Week 6 Pick: Cleveland Browns
Las Vegas Raiders vs Denver Broncos -3
- When: Sunday, Oct. 17
Two reeling squads could make for an entertaining contest. Only one of the two teams, though, lost their head coach this week. Denver is the play.
NFL Week 6 Pick: Denver Broncos
Dallas Cowboys -4 ½ vs New England Patriots
- When: Sunday, Oct. 17
In the hard fought victory over the Houston Texans, the Patriots were without four starting offensive linemen. Even if all four come back, Mac Jones will have a tough time versus Dallas’ defense. More importantly, no defense can stop Dak Prescott and the Cowboys offense.
NFL Week 6 Pick: Dallas Cowboys
Seattle Seahawks vs Pittsburgh Steelers -4 ½
- When: Sunday, Oct. 17
Unless Russell Wilson makes a miraculous recovery, the Steelers win and cover.
NFL Week 6 Pick: Pittsburgh Steelers
Buffalo Bills -5 ½ vs Tennessee Titans
- When: Monday, Oct. 18
The Titans should have no chance. Tennessee allows over 26 points per. The Titans’ D is so bad Zach Wilson and the Jets scored 27 against it in a Tennessee loss in week 5. Jump on the Bills.
NFL Week 6 Pick: Buffalo Bills
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