NFL Week 4 starts off with one of the most important games of the season. The Miami Dolphins head to Cincinnati on Thursday, Sep. 29 to take on the Bengals. Cincinnati and Miami are playoff contenders. So whichever wins the head-to-head in week 4 could be in the driver’s seat for a wildcard. Check out our NFL Betting analysis and a free pick for Dolphins at Bengals and five other must bet NFL Week 4 matchups happening this season.
Must Bet Games in Week 4 of the 2022-23 NFL Season
2022 NFL Week 4
- When: Thursday, Sep. 29 – Monday, Oct. 3
Miami Dolphins at Cincinnati Bengals
- When: Thursday, Sep. 29
The Dolphins have a great defense and a good offense. The key will be whether Tua Tagovailoa can get the ball to Tyreek Hill.
If he can’t, there’s a chance the Bengals roll. Cincinnati should be one of the top contenders for the AFC after shoring up their offensive line. Joe Burrow will have the best season of his young career. Cincinnati is the pick.
NFL Week 4 Pick: Cincinnati Bengals
Buffalo Bills at Baltimore Ravens
- When: Sunday, Oct. 2
Baltimore’s defense won’t stop Buffalo’s offense. Josh Allen should tear apart the Ravens’ overrated secondary.
When Baltimore has the ball, the Bills’ improved defense will stop Lamar Jackson. This happens on Baltimore’s field, which means Buffalo could go off at overlay odds to win SU and to win ATS.
NFL Week 4 Pick: Buffalo Bills
New England Patriots at Green Bay Packers
- When: Sunday, Oct. 2
Patriots versus Packers is a must bet no matter the season. This season, grabbing the points on New England should be the way to go because Green Bay may not be as good as many believe.
Aaron Rodgers will do his part. The defense is okay, but not great, and AR lost his top two targets.
As long as Bill Belichick coaches New England, the Patriots will win games and cover spreads. Backing the Patriots against the spread will be the way to go.
NFL Week 4 Pick: New England Patriots
Denver Broncos at Las Vegas Raiders
- When: Sunday, Oct. 2
Broncos versus Raiders should be an excellent 2-series matchup this season. Russell Wilson throws for the Broncos.
Derek Carr gets to throw to Fresno State teammate Davante Adams for the Raiders. Las Vegas is at home. So the Raiders are the way too early pick, but both teams are for real.
NFL Week 4 Pick: Denver Broncos
Kansas City Chiefs at Tampa Bay Buccaneers
- When: Sunday, Oct. 2
Patrick Mahomes versus Tom Brady. If that isn’t a must bet game, then what is?
The Buccaneers will have home field advantage. The Chiefs should be the better team, though. Kansas City boasts the better offense even if Tyreek Hill is now a Dolphin.
Also, even though the Buccaneers have name players on their defense, we must question it’s ability to pressure Mahomes. KC could be a great moneyline play.
NFL Week 4 Pick: Kansas City Chiefs
Los Angeles Rams at San Francisco 49ers
- When: Monday, Oct. 3
So many questions will have been answered by the time these two face off on Oct. 3. Who is the 49ers’ starting quarterback? Can the Rams’ defense hold up without Von Miller?
Will San Francisco have as effective of a rushing attack now that offensive coordinator Mike McDaniel is the head coach at Miami? No matter the answer to any of the questions, the answer to the most important we already know, the Rams almost never beat the 49ers in San Francisco.
NFL Week 4 Pick: San Francisco 49ers
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