The most important matchup in NFL Week 6 this season projects as Buffalo versus Kansas City. Josh Allen and the Bills must travel to Patrick Mahomes and the Chiefs. Other top week 6 games include New England at Cleveland, and the Saints hosting the Bengals. A couple of important division games, Dallas at Philadelphia and Chargers at Broncos, also happen in week 6. Check out analysis and early NFL Betting picks for seven terrific contests in NFL Week 6.
Must Bet Games in Week 6 of the 2022-23 NFL Season
2022 NFL Week 6
- When: Thursday, Oct. 13 – Monday, Oct. 17
New England Patriots at Cleveland Browns | Sunday, Oct. 16
Deshaun Watson might still be on the bench waiting out an 8-game suspension. If that’s case, Mac Jones and New England should do enough for the road win.
Even if Watson plays, the Patriots could be difficult to beat. If Deshaun does put on the cleats, the Patriots may offer overlay odds against the spread.
NFL Week 6 Pick: New England Patriots
Jacksonville Jaguars at Indianapolis Colts | Sunday, Oct. 16
Jacksonville should be a much better team than people believe. By week 6, we’ll know for sure. If you believe the Jaguars are a decent team, they won’t get as many points versus Matt Ryan and the Colts than we might think. Still, Jacksonville can cover whatever the spread, even if they’re a 1 or 2 point favorite. The Jags have a good defense and Trevor Lawrence will be a much better quarterback in 2022.
NFL Week 6 Pick: Jacksonville Jaguars
Minnesota Vikings at Miami Dolphins | Sunday, Oct. 16
Week 6 is early, but it’s not too early for teams like the Vikings and Dolphins to play for a wildcard spot. Both teams will struggle to win their respective division, Minnesota is in the NFC North and Miami is in the AFC East, but both can make the playoffs via a wildcard.
In this game, the Dolphins have the edge. Unless Tua Tagovailoa doesn’t take the next step, the Fins should play well enough to win and cover.
NFL Week 6 Pick: Miami Dolphins
Cincinnati Bengals at New Orleans Saints | Sunday, Oct. 16
Barring injuries, Bengals versus Saints will be a great game. New Orleans is tough to beat at home and the Saints will have one of the best defenses in the NFL.
Cincinnati improved their offensive line and has a good defense. Because the Saints play in the Superdome, they get the nod against the spread.
NFL Week 6 Pick: New Orleans Saints
Buffalo Bills at Kansas City Chiefs | Sunday, Oct. 16
If Kansas City and Buffalo have both dominated in their first 5 games, this could be a battle for the best record in the league. KC has a big edge because this happens at Arrowhead Stadium, but Buffalo should be the slightly better team.
In last season’s KC versus Buffalo game, the Bills’ Josh Allen dominated. Kansas City’s defense is going to have a tough time containing Allen. Bills win and cover.
NFL Week 6 Pick: Buffalo Bills
Dallas Cowboys at Philadelphia Eagles | Sunday, Oct. 16
Dallas coach Mike McCarthy feels the Cowboys can win the Super Bowl. The roster is deep with talent, Dak Prescott and CeeDee Lamb will be a force, and the defense should be one of the best units in the NFL.
The Eagles feel they’re the class of the NFC East. This game could go a long way in determining which team wins the division. In this head-to-head, the Boys are the play. Dallas has a huge edge at quarterback.
NFL Week 6 Pick: Dallas Cowboys
Los Angeles Chargers at Denver Broncos | Monday, Oct. 17
Chargers versus Broncos is a division game that could determine which AFC West team is in the best position for either a division title or a wildcard spot.
This game should come down to which quarterback can beat the opposing defense. Russell Wilson is good enough to beat the Bolts’ D. But the Chargers’ defense should be better than Denver’s this season.
Justin Herbert could torch the Broncos’ D. LAC has a real shot to grab an SU win. The Chargers should definitely cover.
NFL Week 6 Pick: Los Angeles Chargers
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