NFL Betting Preview Kansas City Chiefs vs. San Francisco 49ers

NFL Betting Preview: Kansas City Chiefs vs. San Francisco 49ers

Written by on October 21, 2022

On Sunday, October 23, 2022, at Levi’s Stadium, the NFC West-leading San Francisco 49ers (3-3) take on the AFC West-leading Kansas City Chiefs (4-2). 

The Chiefs’ most recent game ended in a 24-20 loss against the Buffalo Bills. They will look to bounce back with their potent offense against a tough 49er team. 

The 49ers’ squad hit the road last week in Atlanta but were stunned by the Falcons as the game ended in a 28-14 loss. With both teams looking to rebound, this should be an excellent matchup. 

Let’s take a look at the strengths and weaknesses of both sides and make the best bets for this game.

Chiefs vs. 49ers Game Preview

Chiefs Look to Keep Control of the AFC West

The Kansas City Chiefs are tied for first place in the AFC West with four wins and two losses, but they will look to rebound after falling to the Chiefs at home 24-20. 

Mahomes completed the game with 338 yards passing and two touchdowns but was also picked off twice, including one that was thrown in the end zone early on. JuJu Smith-Schuster recorded five receptions for 113 yards and a score, while the running game managed just 3.3 yards. 

The offense has always been strong for the Chiefs, but the offensive line has been incredibly shaky. The offensive line was expected to be strong in the run game, but something isn’t working there. Overall, the Chiefs rank fourth with 275.8 passing yards per game and are averaging a league-best 29.8 points. 

Kansas City faced the best offense they saw all year and conceded just 24 points. Despite this, they haven’t been playing particularly well, as the unit ranks 20th in total yards allowed (356.5) and 25th in scoring defense (24.8 points allowed per game).

49ers Remain in Tie for First Place in the NFC West

The 49ers are a solid football team, but they have been, unfortunately, ravaged by injuries. Without Nick Bosa and starting linemen Trent Williams and Mike McGlinchy, the 49ers were thrashed on both sides of the ball. Although they remain in a first-place tie in the NFC West, they hope to stop the Chiefs at home and secure a victory.

The Niners’ typically effective running game came to an end last week as Atlanta jumped on the 49ers early. In place of injured starter Elijah Mitchell (knee), Jeff Wilson Jr. had been having a solid season, but he only gained 25 yards on seven attempts, while the ground game totaled 50 total yards. San Francisco finished with fewer than 850 rushing yards in this contest, which was the first time all season.

The 49ers’ defense has been excellent, allowing only 255.8 total yards per game (best). The 49ers’ defense has been instrumental in the team’s success; with 14.8 points allowed per game, they are the second-best in the NFL. The defensive unit has also been fantastic against the pass, as the defense is allowing just 168.3 passing yards allowed per game.

Chiefs vs. 49ers Odds 

The San Francisco 49ers (3-3) and the Kansas City Chiefs (4-2) will square off at Levi’s Stadium, and MyBookie lists the Kansas City Chiefs as -2.5 betting favorites (-110) despite playing on the road. 

The 49ers will be +2.5 (-110) on the spread and +120 on the moneyline in betting underdogs. Meanwhile, the Chiefs are -140 road favorites, with the Over/Under at 48.5 points. 

What’s the Pick?

Ultimately, a furious Patrick Mahomes and a more than adequate receiving group ought to be able to bounce back and succeed in San Francisco. The Chiefs hold one of the best offenses in the league, as they rank first in points per game (29.8). Despite this, they will be playing a defense that ranks first in yards allowed (255.8). 

Expect this game to be a defensive brawl. Neither team will want to give an inch, and they should both play this one safe. The 49ers have started off well, but they were out-hustled by the Atlanta Falcons last week, and they cannot be trusted. 

Patrick Mahomes has not lost to the 49ers once in his career, and the Chiefs have taken four of the last five matchups. Back KC here.

  • MyBookie Prediction: Kansas City Chiefs -2.5 (-110)

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