Making picks in the opening weeks of the new NFL season is always tough. You can look at the rosters and make decisions based on that, but you never really know what you are going to get until the games are actually played. We had a trios of potential Super Bowl favorites – Bills, Ravens, and Packers – all losing their opening games of the season, which perhaps help explain why we had a bit of a mediocre week with our picks in Week 1. We went 2-1 in SU and O/U picks, but just 1-2 in ATS selections. As the weeks progress, we will update our totals for the season and see if we can turn things around once we have some concrete data to pull from. We are now ready to look ahead to Week 2, and specifically, our ATS picks for the week. Let’s get right to it so you can bet against the NFL odds.
Week 2 ATS Picks for the 2021 Season | NFL Betting
Buffalo Bills (-3) at Miami Dolphins
A lot of people were looking at the Buffalo Bills as a legitimate Super Bowl contender this season. They are almost certainly still going to be that, but they quickly found out that getting to the top is not easy. They ran into an absolute buzzsaw in the shape of the Pittsburgh Steelers defense in Week 1, going down 23-16 at home. It’s a disappointing start for the Bills, but one that they can remedy on the road in Week 2. The Dolphins squeezed out a 17-16 win over the Patriots in the opening game, which was a crucial divisional matchup. Despite their Week 1 loss, the Bills are still 8-2 SU in their last 10 and winners of 5 in a row versus the Dolphins. They have also won 6 in a row against divisional foes, so this looks like a win and a cover for Buffalo.
LA Rams (-4) at Indianapolis Colts
Yes, we have only played one week of the season, but it already looks as though the trade that saw Matthew Stafford leave Detroit for LA might well be the deal of the year. Stafford was nothing short of brilliant in Week 1, leading the Rams to a 34-14 win over the Chicago Bears in a game that was as lopsided as the score suggests. This will prove to be a tougher challenge, but you still need to like the Rams to get the job done on the road. After all, they have covered the spread in 6 of their last 8 meetings with the Colts and are 4-1 ATS in their last 5 games played in Week 2 of the season. I think this spread is a bit of a bargain, which is why I am all over it.
New Orleans Saints (-4) at Carolina Panthers
We were all sitting back waiting to see what Jameis Winston would do in his first game with the Saints. After all, he was replacing an absolute legend in Drew Brees, albeit on a team that looks ready to win now. If his Week 1 display was anything to go by, the Saints might be a legit contender this season, as Winston helped his team blow past the Green Bay Packers in a lopsided 38-3 win. The Panthers got some good work from their new QB, Sam Darnold, in a win over the Jets, but they look outmanned this weekend. The Saints have now covered in 4 of their last 5, and while they don’t have a great ATS record versus the Panthers, I think they cover in this one.
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