Betting NFL Week 16 Quarterbacks Picks for Top Matchups

With 2024 NFL Week 16 underway, it’s time to dive into the most exciting betting NFL Week 16 Quarterbacks picks. This week, we’ve got some thrilling quarterback matchups that will have a major impact on playoff positioning. Thursday’s game features Bo Nix leading the Denver Broncos against Justin Herbert and the Chargers, while Saturday brings two epic duels: Lamar Jackson vs. Russell Wilson in Ravens-Steelers, and Patrick Mahomes vs. CJ Stroud in Chiefs-Texans.

2024 NFL Week 16 Picks for the Top Quarterback Matchups
NFL Week 16 Face-Off: The Best QB Duels of the Week

2024 NFL season | 104th season of National Football League in the United States
Week 16: Thursday, December 19th – Monday, December 23rd, 2024

Betting NFL Week 16 Quarterbacks Picks

Three of this week’s top quarterback matchups happen in both Saturday games and in Thursday’s game.

The action kicks off on Thursday Night when Bo Nix leads the Denver Broncos to SoFi Stadium to take on Justin Herbert and the Bolts.

Then on Saturday, Lamar battles Russ when the Ravens host the Steelers and Magic Mahomes duels with CJ Stroud when the Texans travel to KC to take on the Chiefs.

Check out more info on this week’s top NFL QB matchups. 

Writer’s NFL Quarterback Picks for the Week 16 Matchups

Denver – Bo Nix at LAC – Justin Herbert

Thursday, December 19th, 2024

Herbert has thrown a single interception this season.

But the Chargers’ defense depends a lot on the rush and doesn’t put Justin into passing situations often.

That may not be the case in this game.

Bo Nix is going to throw at will.

Nix can also rush.

So when it comes to the matchup, Bo wins even though the Chargers will be tough to beat at home.

NFL Week 16 QB Pick: Bo Nix  

Houston – CJ Stroud at Kansas City – Patrick Mahomes

Saturday, December 21st, 2024

If this game happened earlier in the season, Stroud would be the pick to post better stats than Mahomes.

At this late stage, though, the Magic One is the choice.

Mahomes is heating up.

The reason? The Chiefs acquired De’Andre Hopkins, still one of the top wide receivers in the NFL, rookie Xavier Worthy is often the fastest player on the field, and JuJu Smith-Schuster is back in the fold.

Oh, yes, it’s a matter of time before Travis Kelce starts to dominate.

NFL Week 16 QB Pick: Patrick Mahomes

Pittsburgh – Russell Wilson at Baltimore – Lamar Jackson

Saturday, December 21st, 2024

Wilson versus Jackson could go one of two ways.

It could be a duel on the level of Burrow versus Wilson, which Russ won in a wild high-scoring game.

Or it could be a classic Steelers versus Ravens matchup where Mike Tomlin’s defense dictates the outcome.

I like Tomlin to continue his mastery of Lamar and Baltimore’s offense, which means Russ wins the duel even if he doesn’t post mind blowing stats.

NFL Week 16 QB Pick: Russell Wilson  

Philadelphia – Jalen Hurts at Washington – Jayden Daniels

Sunday, December 22nd, 2024

Daniels is great but Jalen has the upper hand in this.

Hurts has many more weapons and a top running back in Saquon Barkley to keep off the pressure.

Also, Hurts is one of the best rushing and passing quarterbacks in the NFL.

Even though the Commanders are at home, the Eagles should get the offense going versus a D.C. defense that doesn’t always show up.

NFL Week 16 QB Pick: Jalen Hurts  

Minnesota – Sam Darnold at Seattle – Geno Smith

Sunday, December 22nd, 2024

Both quarterback project to have decent games.

Both QBs also have great targets.

Justin Jefferson is the top receiver in this game but DK Metcalf can post Jefferson like stats on any given Sunday.

Geno has the edge because this is on his field.

Still, Darnold has been good all season.

So it’s tough to go against the former USC Trojans. 

NFL Week 16 QB Pick: Sam Darnold  

San Francisco – Brock Purdy at Miami – Tua Tagovailoa

Sunday, December 22nd, 2024

If Purdy had his full arsenal, he’d be the pick.

But the Niners have struggled all season with injuries to their top players, especially Christian McCaffrey and Brandon Ayuik.

Also, Tua is tough to beat at home.

The Dolphins should roll in this game as well as Tagovailoa posting exceptional stats.

NFL Week 16 QB Pick: Tua Tagovailoa  

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Tua Tagovailoa in games against teams with a record over .500 pic.twitter.com/nNn0luTLej

— Zach 🌎 (@zzachary_1) December 15, 2024

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