March Madness NCAAB Sweet 16 Betting Picks

The NCAAB Sweet 16 betting picks are in, and with a mix of powerhouse favorites and dangerous underdogs, this round of March Madness promises big opportunities for sharp bettors. By analyzing key matchups and shifting college Basketball odds, you can spot the best value bets and maximize your winnings in this year’s NCAA Tournament.

2025 March Madness Sweet 16 Betting Predictions from MyBookie
Bracket-Busting Predictions: The HIDDEN Strategies of the Sweet 16!

2025 College Basketball Season | 86th season of the National Collegiate Athletic Association Division I men’s college basketball
March Madness: Tuesday, March 18th – Monday, April 7th, 2025

Betting March Madness Matches

The 2025 NCAA Tournament Sweet 16 is set, and bettors are preparing for another exciting round of March Madness.

The field features several top seeds like Duke, Florida, Auburn, and Houston, but a few lower-seeded teams have made impressive runs to this point.

The mix of powerful favorites and surprising underdogs creates plenty of betting angles.

In this year’s tournament, favorites have performed well overall.

However, teams like Arkansas and Michigan have proven that lower seeds can still pull off key wins.

The Sweet 16 is a critical round where some of the biggest betting opportunities often emerge.

Identifying teams with momentum, favorable matchups, and key betting trends can help bettors gain an edge.

This guide breaks down five teams to watch, potential upset picks, and expert analysis on the best betting opportunities in the Sweet 16.

Additionally, we’ve included a detailed look at key players to watch in the tournament who can make a difference for their teams.

With this information, bettors can feel confident placing informed wagers on the upcoming Sweet 16 matchups.

Writer’s Rundown on Betting on NCAAB Sweet 16 Betting Picks

Top 5 Teams to Bet on in the Sweet 16

Team #1 (Top Pick): Duke

Duke enters the Sweet 16 as one of the most well-rounded teams remaining in the tournament.

The Blue Devils excel on both ends of the floor, ranking in the top five in both offensive and defensive efficiency.

Their ability to score inside, shoot from the perimeter, and control the pace of play makes them a reliable betting option.

Duke opened the tournament with a dominant win over Vermont, winning 84-55 while easily covering the spread.

In the Round of 32, they eliminated Baylor with a 75-62 victory, again showing their ability to control the pace and limit turnovers.

Duke’s defensive pressure has been especially effective, holding both opponents well below their season scoring averages.

Cooper Flagg has been the driving force behind Duke’s success.

The star forward is averaging 18 points, 9 rebounds, and 3 blocks per game in the tournament.

Flagg’s defensive presence in the paint combined with his scoring versatility makes Duke a dangerous team in the Sweet 16.

Betting trends also support Duke’s chances, as ACC teams favored by 7+ points have shown recent improvement ATS in tournament play.

In their upcoming Sweet 16 matchup against Arizona, Duke’s defensive discipline and depth should give them an edge.

With Arizona relying heavily on three-point shooting.

Duke’s ability to close out on shooters and contest perimeter attempts could be the difference in covering the spread.

Team #2 (Second Pick): Florida

Florida has emerged as one of the most dangerous teams in the tournament.

The Gators lead the nation in offensive efficiency and have shown the ability to dominate teams with their fast-paced attack.

Florida’s strong ball movement, perimeter shooting, and defensive rebounding have helped them win key matchups.

Florida’s path to the Sweet 16 has been impressive.

They crushed Colgate 88-63 in the opening round, covering as a heavy favorite.

In the Round of 32, Florida pulled away late against Kansas, winning 82-70 in a game where the Gators shot 52% from the field.

Florida’s ability to extend leads late in games has made them a strong ATS performer.

Riley Kugel and Walter Clayton Jr. have led Florida’s offense.

Kugel’s ability to hit deep threes stretches opposing defenses, while Clayton’s dribble penetration has created open looks for Florida’s shooters.

The duo has combined for 34 points per game in the tournament.

Florida’s next matchup against Maryland presents a favorable betting opportunity.

Maryland’s slower-paced offense often struggles against fast-paced teams that apply pressure.

With Florida excelling in transition, they should be able to cover the 5.5-point spread and move on to the Elite Eight.

Team #3 (Potential Sleeper): Arkansas

Arkansas has played its best basketball of the season during March Madness.

After struggling earlier in the year, the Razorbacks have improved defensively while maintaining their aggressive rebounding and transition scoring.

As a No. 10 seed, Arkansas is proving they can take down higher seeds.

Arkansas opened the tournament by upsetting No. 7 St. John’s 78-72.

In the Round of 32, they followed up with a 70-66 win over Colorado, relying on key defensive stops in the final minutes.

Arkansas has thrived in close games, with their guard play and rebounding giving them a key advantage late in contests.

Khalif Battle has been the Razorbacks’ standout performer.

Battle scored 22 points in the upset over St. John’s and added 19 points against Colorado.

His ability to create his own shot has been critical in Arkansas’ ability to stay competitive.

Against Texas Tech in the Sweet 16, Arkansas fits a key underdog trend.

Teams seeded No. 10 or worse with spreads of 4+ points are 14-4 ATS in recent years.

Arkansas’ physical defense and clutch scoring make them a strong bet to cover again in this round.

Team #4 (Contender with Tough Matchup): Houston

Houston continues to dominate defensively.

The Cougars rank No. 1 in adjusted defensive efficiency and have suffocated opponents with their aggressive ball pressure and rebounding.

Houston’s ability to control tempo has made them a reliable betting option in low-scoring matchups.

Houston defeated Yale 69-55 in the opening round, holding the Bulldogs to 37% shooting.

In the Round of 32, they dominated Texas A&M 66-54 by forcing 18 turnovers and limiting the Aggies to 2-of-17 shooting from three-point range.

Jamal Shead has been Houston’s key playmaker.

Shead’s ability to control the tempo and apply defensive pressure has helped Houston win key games.

His leadership will be vital as Houston faces Purdue in the Sweet 16.

Team #5 (Cinderella Story): Michigan

Michigan has been one of the biggest surprises in this year’s tournament.

As a No. 6 seed, the Wolverines upset No. 4 Marquette 68-63 in the opening round.

They followed that with a 72-65 win over Arizona State, thanks to strong perimeter defense and clutch shooting down the stretch.

Terrance Williams II has been a difference-maker for Michigan.

Williams scored 16 points against Marquette and played a key defensive role in Michigan’s win over Arizona State.

His ability to defend multiple positions gives Michigan flexibility against Auburn in the Sweet 16.

Michigan faces a tough challenge against Auburn, but their improved outside shooting gives them a chance to cover as a +7.5 underdog.

With Auburn struggling to defend perimeter shooters, Michigan’s scoring threats give them value in this matchup.

Key Players to Watch with Our NCAAB Sweet 16 Betting Picks

Cooper Flagg (Duke):
Strong two-way presence who controls the paint and scores efficiently.
Walter Clayton Jr. (Florida):
Reliable scorer who can create shots and distribute the ball.
Khalif Battle (Arkansas):
Explosive scorer who thrives in clutch moments.
Jamal Shead (Houston):
Defensive stopper and key facilitator on offense.
Terrance Williams II (Michigan):
Versatile defender and key shooter in close games.

NCAA Sweet 16 Starts Thursday!

The Sweet 16 offers a mix of strong favorites and dangerous underdogs.

Duke, Florida, and Houston present strong value as favorites, while Arkansas and Michigan provide betting opportunities as underdogs.

Each team’s ability to control tempo and make defensive stops will play a major role in their success.

Bettors should pay attention to matchups, momentum, and key betting trends when placing their Sweet 16 wagers.

With the right analysis, the Sweet 16 offers plenty of profitable opportunities in this year’s NCAA Tournament.

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THE SWEET 16 IS LOCKED IN

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