The New York Jets host AFC East rival Buffalo in NFL Week 10 as a big time -7.5 favorite. NYJ hopes to grab another victory while the Bills hope that they get decent play from the quarterback position. Which team takes it in what should be an entertaining AFC throw down on Sunday?
The Jets are 3-6 both straight up and against the spread, but they’ve gone 2-2 against the spread at home. NYJ counters any defensive flaws in this matchup because they battle one of the worst, most horrible, offenses in NFL history.
Although Buffalo’s defense is good, Jets quarterback Sam Darnold has excelled in 2-of-4 home games. He played to a 98.1 quarterback rating in a win over the Denver Broncos in Week 5. In Week 6, he played to a 113.9 quarterback rating in a win over the Indianapolis Colts.
If the good Darnold shows up, the Jets should beat the Bills by at least 14 points.
MyBookie NFL
Bills at Jets NFL Week 10 Lines & Expert Prediction
- When: Sunday, Nov. 11 at 1:00 pm ET
- Where: MetLife Stadium, East Rutherford, NJ
- TV: CBS
- Over/Under Total Odds: 36.5 (-110)
Weather Forecast
- Partly Cloudy: 7°C/44°F
- Humidity: 41%
- Precipitation: 0%
- Wind: 9 mph W
- Cloud Cover: 30%
- Type of Stadium: Open
Why Buffalo Bills are a good bet at +7.5?
Although Buffalo’s offense is a mess, it only averages 10.7 points per, the Bills defense is actually decent. Buffalo ranks 3rd in the NFL in passing yards allowed. Teams average 212 yards against Buffalo’s defense. Overall, the Bills rank 3rd in total yards allowed. Opponents only average 313.7 total yards. If starting quarterback Nathan Peterman can protect the football, he’s thrown 7 interceptions in only 4 games played, Buffalo could keep this one closer than 8 points.Team Statistics
Offense:- Average Score For: 13.8
- Total Yards: 233.2
- Pass Yards: 165.8
- Rush Yards: 67.5
- Average Score Against: 24.9
- Total Yards: 367.8
- Pass Yards: 224.6
- Rush Yards: 143.1
Why New York Jets are a good bet at -7.5?

Team Statistics
Offense:- Average Score For: 10.7
- Total Yards: 248.3
- Pass Yards: 151.1
- Rush Yards: 97.2
- Average Score Against: 26.8
- Total Yards: 313.7
- Pass Yards: 212
- Rush Yards: 101.7
NFL Football Betting Trends for Buffalo Bills at New York Jets
- Bills are 0-6 ATS in their last 6 road games versus a team with a losing home record
- Bills are 3-8 ATS in their last 11 versus the AFC East
- Jets are 5-1 ATS in their last 6 at home versus a team with a losing road record
- Jets are 10-3 ATS in their last 13 home games
Bills at Jets Final NFL Betting Analysis
The Bills will start quarterback Derek Anderson if rookie Josh Allen can’t go. Allen’s been upgraded from doubtful to questionable due to an elbow injury. He should suit up for this game on Sunday. If he does, the Bills have a shot to not only cover, but to also beat the Jets straight up. Because Allen’s expected to play, Buffalo’s the team to back. Even if Allen doesn’t go, Derek Anderson should provide enough of a lift to keep this one closer than the spread. NFL Football Week 10 Pick: Buffalo Bills +7.5MyBookie NFL
NFL Odds and Lines
NFL Game Lines |
NFL Playoff Odds |
Super Bowl Odds |
AFC Champion Odds |
NFC Champion Odds |
NFL Trends
NFL Loyalty Program |
Futures to Reach the Playoffs |
Super Bowl Rematches |
- NFL Week 1 Betting: Is Your Favorite Team a Lock or a Letdown?
- Offense Wins Titles, But This NFL QB Prop Bet Wins You Money
- Earn Points, Get Exclusive Bonus and Win this 2025 Season with our NFL Loyalty Program
- When the NFL Goes International, Fan Behavior Hits Your Bets – Use Fading Public Bias
- Here’s Why Public Money Could Be Your Indicator for NFL Week 1 Value Bets
- Same-Game NFL Parlay Hacks: Score Big on One Game