Cardinals vs 49ers NFL Week 5 Lines & Expert Pick

The Arizona Cardinals travel to San Francisco to battle the 49ers looking to win their first of the season. Zona is the only team in the NFL without a victory. Can the Cardinals upset favored San Francisco? Or, will the 49ers add to Arizona’s 2018 misery? Check out our NFL Week 5 odds, analysis, and a free pick when Arizona battles San Francisco!

Cardinals vs 49ers NFL Week 5 Lines & Expert Pick

When: Sunday, Oct. 7 at 4:25 pm ET
Where: Levi’s Stadium, Santa Clara, CA
TV: FOX
Radio: Arizona / San Francisco
ATS Odds: Arizona +4.5 (-110)
Over/Under Total Odds: 41 (-110)

Weather Forecast

Clear: 24^°C/76^°F
Humidity: 27%
Precipitation: 0%
Wind: 19 mph NNW
Cloud Cover: 3%
Type of Stadium: Open

**Why are the Cardinals a good bet at +4.5?**

Are the Cardinals a safe bet for NFL Week 5?

The Cardinals have shown signs in their past couple of games that they can compete in the NFL. In Week 3, they almost pulled off the upset win over the Chicago Bears. Arizona only lost 14-16. Zona’s defense played huge. In Week 4, Arizona lost 17-20 to the rival Seattle Seahawks as a 3.5 home dog. Again, Arizona’s defense came up huge. Now in Week 5, Arizona battles a team with a backup quarterback, C.J. Beathard. If Arizona’s defense comes up huge again, the Cardinals can beat the 49ers straight up.

Team Statistics

Offense:

Average Score For: 9.2
Total Yards: 208.5
Pass Yards: 141.8
Rush Yards: 66.8

Defense:

Average Score Against: 23.5
Total Yards: 377
Pass Yards: 235.8
Rush Yards: 141.2

**Why are the 49ers a good bet at -4.5?**

Even without starting quarterback Jimmy Garoppolo, the San Francisco 49ers can move the football and score points. SF entered their game against the L.A. Chargers a +10 road dog. They left their game against the Chargers 27-29 losers. Sure, the 49ers lost but they squashed the spread by 8 points. Quarterback C.J. Beathard threw for 298 yards and 2 touchdowns. Tight-end George Kittle caught 6 of 8 targets for 125 yards and a TD. San Francisco’s got a bad defense, but the Cardinals have a bad offense. If the 49ers’ offense performs in Week 5 the way it performed in Week 4, San Francisco should win and cover the spread.

Team Statistics

Offense:

Average Score For: 25
Total Yards: 360.8
Pass Yards: 227.2
Rush Yards: 133.5

Defense:

Average Score Against: 29.5
Total Yards: 380.5
Pass Yards: 276.2
Rush Yards: 104.2

Cardinals at 49ers NFL Week 5 Betting Trends

Arizona is 4-2 ATS in its last 6 games
Arizona is 1-4 SU in its last 5 games
The total has gone UNDER in 7 of Arizona’s last 8 games
San Francisco is 6-3 SU in its last 9 games
San Francisco is 8-17 SU in its last 25 games
The total has gone OVER in 6 of San Francisco’s last 7 games

Arizona Cardinals at San Francisco 49ers Final Analysis

Football’s about individual matchups. That’s why more than 60% of NFL handicappers back the Arizona Cardinals at +4.5 against the San Francisco 49ers. This looks like a terrible matchup for the 49ers. San Francisco’s offense got to play a bad defense. This Sunday, San Francisco’s offense must play a defense that’s performed great against better quarterbacks. Chicago’s Mitch Trubisky is on his way to being one of the top quarterbacks in the NFC while Seattle’s Russell Wilson is already one of the top quarterbacks in the NFL. While Beathard threw 2 TD passes against the Chargers bad defense, he also threw 2 interceptions. If Cardinals’ QB Josh Rosen doesn’t make mistakes, AZ’s defense should help the Cards win their first game of the season. NFL Football Week 5 Pick: Cardinals money line