Betting Bills vs Colts Pick for NFL Week 10: Odds and Pick

As the Buffalo Bills head into their Week 10 matchup against the Indianapolis Colts, questions are mounting around their recent struggles and injury woes. Meanwhile, the Colts, currently 4-5, aim to stay competitive in the AFC wild-card race. With so much at stake, NFL game odds for this crucial AFC showdown are drawing attention from bettors eager to make informed picks. Here’s a breakdown of the odds, team form, injury impact, and betting insights for the Bills vs. Colts in Week 10.

Betting Bills vs Colts Pick for the 2024 NFL Week 10
NFL Week 10 Firestorm: Bills vs. Colts – Who Will Reign Supreme?

2024 NFL Season | 104th season of National League in the United States
Week 10: Thursday, October 31st – Monday, November 4th, 2024

Betting 2024 Buffalo Bills at Indianapolis Colts Week 10 Game

As the Buffalo Bills head into their Week 10 matchup against the Indianapolis Colts, questions are mounting around their recent struggles and injury woes.

Buffalo has won four straight games, yet confidence seems to be waning as they prepare for a road game at Lucas Oil Stadium.

Meanwhile, the Colts, currently 4-5, aim to stay competitive in the AFC wild-card race.

Here’s a breakdown of the odds, team form, injury impact, and betting insights for this crucial AFC showdown.

NFL Week 10: Buffalo Bills at Indianapolis Colts
Sunday, October 27th, 2024 at 1:00 PM EST CBS | GEHA Field at Arrowhead Stadium, Kansas City, MO

ATS Odds: Buffalo -4
Money line Odds: Bills -210, Colts +170
Over/Under Odds: 46

Writer’s Breakdown and Pick for the Bills vs Colts Game

Buffalo Bills Analysis

The Bills have cruised through their past few games, overcoming teams like the Miami Dolphins and Seattle Seahawks.

However, injuries are starting to impact their lineup.

Wide receiver Keon Coleman and defensive end Dawuane Smoot both suffered wrist injuries last week, with Smoot now on injured reserve.

These absences are notable for a team already facing challenges in both passing and rushing defenses.

Quarterback Josh Allen remains a major factor, leading an offense that has scored over 30 points in six games this NFL season.

Allen’s effectiveness will be critical, especially as the Bills attempt to work around their injury-laden defense.

With upcoming games against stronger opponents like the Kansas City Chiefs, the Bills need to secure this victory to maintain momentum in the AFC.

Indianapolis Colts Analysis

The Colts have had a mixed season but remain competitive, with all nine of their games decided by eight points or less.

Veteran quarterback Joe Flacco is expected to start again after a poor showing last week, where the team reached season-lows in points and first downs.

Flacco’s ability to rebound will be essential, especially as the Colts face a Bills team vulnerable to running attacks.

Indianapolis has consistently stayed close in games, largely due to their run game and a defense that can hold its ground against good offenses.

While Buffalo has struggled in rushing defense, the Colts have an opportunity to capitalize if they can establish an early lead.

However, their secondary faces a challenge in containing Allen and his quick passing attack.

Colts vs. Bills Betting Predictions

Buffalo’s injuries could play a significant role, especially if Coleman’s absence limits Allen’s receiving options and Smoot’s IR status weakens their pass rush.

The Bills recent betting trends indicate a decrease in confidence.

This is a pivotal moment for the Bills to regain their footing.

This game looks set to be competitive, with Buffalo’s edge riding on Josh Allen — and the Colts leaning on their ground game.

However, the Bills may struggle to cover the spread if the Colts can control the clock and limit Allen’s opportunities.

Writer’s Prediction: Bills 24, Colts 21

NFL Week 10 SU Pick: Indianapolis Colts -250

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Buffalo at Indianapolis Betting Trends Today

Buffalo are 0-6 SU in their last 6 games when playing on the road against Indianapolis.
Buffalo are 11-3 SU in their last 14 games against an opponent in the American Football Conference conference.
The total has gone OVER in 4 of Buffalo’s last 6 games against an opponent in the American Football Conference South division.
Buffalo are 1-5 ATS in their last 6 games played in November.
Indianapolis are 6-0 ATS in their last 6 games against an opponent in the American Football Conference conference.
Indianapolis are 6-1 SU in their last 7 games against an opponent in the American Football Conference East division.
The total has gone UNDER in 4 of Indianapolis’ last 6 games played in November.
The total has gone UNDER in 6 of Indianapolis’ last 8 games played on a Sunday

Colts vs. Bills Series History

Last meeting:
Bills 15, Colts 41: November 21st, 2021: Week 11 – Highmark Stadium, Orchard Park, NY

Head-to-head (includes postseason games):
Buffalo Bills lead series 38-33-1

From @GMFB: #Chiefs WR Rashee Rice is feared to have torn his ACL; #Colts QB Anthony Richardson (hip pointer) escaped major injury; RB Jonathan Taylor has a mild high-ankle sprain. pic.twitter.com/zaCq9A0nyD
— Ian Rapoport (@RapSheet) September 30, 2024