NFL Divisional Round Picks: Top Quarterback Matchups to Watch and Bet On

As you dive into betting NFL Divisional Round Quarterbacks picks, it’s essential to break down the top quarterback matchups that will shape this year’s postseason. With Jared Goff’s showdown against either Matthew Stafford or Sam Darnold, Lamar Jackson facing Josh Allen, Patrick Mahomes vs. C.J. Stroud, and Jalen Hurts squaring off with Jayden Daniels, these individual duels are poised to define the 2025 NFL Divisional Round.

2025 NFL Divisional Round Picks for the Top Quarterback Matchups
Dominate the Playoffs: Divisional Round Weekend Quarterback Betting Tips

2025 NFL season | 106th season of National Football League in the United States
Divisional Round: Saturday, January 18th – Monday, January 19th, 2025

Betting Quarterbacks for the NFL Divisional Round Games

Detroit doesn’t know the team they will play next week but for every other squad, individual matchups are set.

Jared Goff will face off against either Rams’ signal caller Matthew Stafford or Vikings’ quarterback Sam Darnold.

Baltimore and Lamar Jackson go up against Josh Allen and the Bills.

Patrick Mahomes and the Chiefs await C.J. Stroud and the Texans and Jalen Hurts and the Eagles go up against Jayden Daniels and the Commanders.

Which quarterbacks win their individual duels?

Check out analysis and picks for this weekend’s NFL Divisional Round QB matchups. 

Writer’s NFL Quarterback Picks for the Divisional Round Matchups

AFC Divisional Round QB Matchups / Saturday, January 18th, 2025

Houston – C.J. Stroud at Kansas City – Patrick Mahomes

Stroud got it going in the impressive 32-12 wild card win over the Los Angeles Chargers.

But before signing on Stroud making it two in a row versus a rival as an underdog, we have to put things in perspective.

The Bolts had a sweet 6-0 lead until the wheels fell off.

Once those wheels disintegrated, Justin Herbert could do nothing right.

Herbert threw 4 interceptions and the Chargers had turnover after turnover.

Stroud faces a much taller task against the well-rested KC defense this weekend.

The Chiefs are a solid -7.5 favorite.

It’s difficult to argue against those odds because Stroud must still go to the Nico Collins well and unlike the Chargers, Steve Spagnuolo is going to find a way to contain Collins.

Also, Joe Mixon won’t have the truck sized holes to run through against the Chiefs.

Patrick Mahomes has his full arsenal.

DeAndre Hopkins, Hollywood Brown, Travis Kelce, Isaiah Pacheco and Xavier Worthy are all healthy.

So is the KC offensive line.

The Magic One outduels Stroud in a game that the Chiefs win and cover. 

NFL Divisional Round QB Pick: Patrick Mahomes

Baltimore – Lamar Jackson at Buffalo – Josh Allen

AFC Divisional Round QB Matchups / Sunday, January 19th, 2025

The two best quarterbacks in the NFL this season go head-to-head in what should be a fantastic matchup.

Josh Allen and the Buffalo Bills dominated the Denver Broncos 31-7 in their wild card matchups while Lamar and the Ravens beat the rival Pittsburgh Steelers 28-14.

Allen threw for 272 yards and 2 touchdowns. He had his way with a decent Denver defense.

But Josh also ran for 46 yards from 8 carries.

Lamar tossed 2 touchdowns and passed for 175 yards.

Jackson also rushed for 81 yards from 15 carries.

Both quarterbacks are going to use their legs in this.

Both will have success throwing the football.

The difference, though, is that Allen is going to have to do more in this game than he did in the win over the Broncos.

James Cook is a good running back.

But he’s not Derrick Henry.

Henry takes a lot of pressure off Jackson.

If Henry has a decent game, and he should, Lamar is going to have to do less even though the Ravens win the game.

Expect a massive performance from both quarterbacks.

But in the end, because he doesn’t have a running back the caliber of future hall of famer Derrick Henry, the Buffalo quarterback posts the better stats even though his team could lose straight up.

NFL Divisional Round QB Pick: Josh Allen

Washington – Jayden Daniels at Philadelphia Jalen Hurts

NFC Divisional Round QB Matchups / Saturday, January 18th, 2025

The Philadelphia Eagles used a stifling defense and fantastic play from Jalen Hurts and Saquon Barkley to put the clamps on Jordan Love and the Green Bay Packers in an impressive 22-10 wild card win.

Although the Eagles didn’t score more than 22, the victory was ultra impressive because of how Hurts managed the game.

Jalen didn’t post tremendous stats. He didn’t have to.

Instead, he took his time, picked his spots and got the job done.

This weekend, Hurts may have to air it out because he faces a familiar foe, the Washington Commanders.

Jayden Daniels and the Commanders won a tight game versus Bakery Mayfield and the Bucs.

How tight? The reason the Commanders take on the Eagles is because the last second field goal hit the post and then went through the uprights.

There’s a chance we see a shootout this weekend.

If a shootout happens, we should expect Hurts to get the upper hand versus Daniels.

The reason Washington rallied to beat the Eagles in the second game this season is because Jalen got hurt.

A healthy Jalen means the Eagles win and cover and Hurts beats Daniels in the stats department.

NFL Divisional Round QB Pick: Jalen Hurts

LAR – Matthew Stafford / Minnesota – Sam Darnold at Detroit – Jared Goff

NFC Divisional Round QB Matchups / Sunday, January 19th, 2025

The Rams and Vikings play in Arizona on Monday Night Football.

So at the time of this writing, we don’t know exactly which team and quarterback faces off against the Detroit Lions and Jared Goff.

As far as QB matchups are concerned, it doesn’t matter.

Whether it is Darnold or Staff, Goff wins the matchups.

If it was any other NFL season, if Josh Allen and Lamar Jackson didn’t have the seasons they had, Goff would be the MVP.

He plays for the team with the best record in the league.

He threw for 4,629 yards and 37 TDs to just 12 interceptions.

Goff has a plethora of weapons including the best pass catching running back in the NFL, Jahmyr Gibbs.

Goff is going to post monster stats against either the Rams or the Vikings.

But if you go against Goff, only do so if plays Stafford and the Rams.

The Rams D has been excellent in recent games and Staff has as many weapons.

So Stafford could eke out a victory.

NFL Divisional Round QB Pick: Jared Goff

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