Patriots vs Bills Pick: NFL Week 16 Betting Preview

In a high-stakes matchup for NFL Week 16, the Patriots vs Bills pick is set to be one of the most exciting games of the season, as the New England Patriots (10-3) take on the Buffalo Bills (11-2) at Lincoln Financial Field on Sunday, December 15, 2024. With both teams sitting atop their respective divisions, this game has major playoff implications, making it a must-watch for fans and bettors alike.

Betting Patriots vs Bills Pick for the 2024 NFL Week 16
AFC East Showdown: Patriots vs. Bills – Who Will Dominate?

2024 NFL Season | 104th season of National League in the United States
Week 16: Thursday, December 19th – Monday, December 23rd, 2024

Betting 2024 New England Patriots at Buffalo Bills Week 16 Game

In a key AFC East showdown, the New England Patriots visit the Buffalo Bills in Week 16 of the NFL season.

This matchup has significant playoff implications for both teams, especially for Buffalo, who are battling for the top seed in the AFC.

With the game set for Sunday, December 22, 2024, at Highmark Stadium, fans can expect a heated contest between two teams with much at stake.

The Bills are heavily favored at home, but the Patriots, despite their struggles, are looking to play spoiler.

Buffalo enters the game with an 11-3 record and sits atop the division.

They have one of the league’s best offenses, averaging 31.8 points per game, and are led by MVP candidate Josh Allen.

Meanwhile, the Patriots have endured a tough season, sitting at 3-11, but they have shown some competitiveness in recent weeks.

This game represents an opportunity for New England to disrupt Buffalo’s path to a first-round bye while potentially building momentum for next season.

NFL Week 16 Showdown: New England Patriots (3-11) at Buffalo Bills (11-3)
Sunday, December 22nd, 2024 at 4:25 PM EST FOX | Highmark Stadium, Orchard Park, NY

ATS Odds: Buffalo -14
Money line Odds: Patriots +690, Bills -1205
Over/Under Odds: 46.5

Writer’s Pick for the Patriots vs Bills Game Starting Sunday’s Round of Afternoon Action

Playoff Implications

The Bills are in a heated race with the Kansas City Chiefs for the AFC’s No. 1 seed and a coveted first-round bye.

A win against New England keeps them in contention, but a loss could put their chances in jeopardy.

Buffalo’s high-scoring offense has been their calling card all season, but their defense has had moments of inconsistency, which New England may try to exploit.

For the Patriots, there are no playoff hopes on the line, but pride and player development remain critical.

Quarterback Drake Maye, in his rookie season, has shown glimpses of potential but will face a tough test against Buffalo’s defense.

New England’s focus will be on evaluating talent and building for next year, making this game an important measuring stick against one of the league’s best teams.

Betting New England Patriots Lines to Win

The Patriots have had a challenging season, but they’ve shown grit in several games.

Rookie quarterback Drake Maye has thrown for 2,707 yards and 15 touchdowns this season, though turnovers have been an issue with 10 interceptions.

Maye will rely on weapons like wide receivers DeMario Douglas and Kendrick Bourne, who have combined for over 1,000 receiving yards this season.

Tight end Hunter Henry has also been a reliable target, contributing five touchdowns.

New England’s rushing attack is led by Rhamondre Stevenson, who has rushed for 869 yards and six touchdowns.

The Patriots’ offensive line will need to step up to give Maye time in the pocket and create running lanes for Stevenson.

Defensively, New England has struggled, ranking 30th in total yards allowed.

However, edge rusher Matthew Judon remains a bright spot with seven sacks on the season.

To have a chance, the Patriots will need to force turnovers and capitalize on Buffalo’s mistakes.

Betting Buffalo Bills Lines to Win

Buffalo comes into the game as one of the hottest teams in the league.

Quarterback Josh Allen continues to dominate, throwing for 3,395 yards and 25 touchdowns while adding 11 rushing scores.

His dual-threat ability has made the Bills’ offense one of the most dangerous in the NFL.

Running back James Cook has also been effective, rushing for over 1,000 yards and 14 touchdowns, giving Buffalo a balanced attack.

The Bills’ defense, while solid overall, has shown vulnerability in recent weeks.

They allow 345.5 yards per game and have struggled against the pass, ranking 25th in passing yards allowed.

However, edge rusher Greg Rousseau and linebacker Matt Milano provide a strong defensive presence.

The secondary, led by cornerback Christian Benford, will look to shut down New England’s passing game and create turnovers to give Allen and the offense more opportunities.

Next NFL Games to Follow

Following this matchup, Buffalo will face the Los Angeles Chargers in Week 17, a game that could further impact their playoff seeding.

They’ll then close the regular season with a critical rematch against the Patriots in Week 18.

For New England, their remaining schedule includes a home game against the Chargers and the aforementioned trip to Buffalo.

These games will provide additional opportunities to evaluate young talent and build toward the 2025 season.

Bills vs. Patriots Pick and Score Prediction

Buffalo’s offense is likely to overpower New England in this matchup.

The Bills have too many weapons and a quarterback in Josh Allen who can exploit the Patriots’ defensive weaknesses.

While the Patriots’ offense has shown improvement, their inability to protect the ball and finish drives will make it difficult to keep pace with Buffalo’s high-powered attack.

Score Prediction: Buffalo 34, New England 17

NFL ATS Pick: Buffalo -14
NFL Total Pick: Over 46.5

Bet the NFL Week 16 Games | NFL Live Betting MyBookie Betting Lines for the Tournament

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New England at Buffalo Betting Trends Today

Bills are 9-5 against the spread this season.
Patriots are 5-8-1 against the spread this season.
Patriots are 2-7 straight up in Drake Maye’s starts this season.
Bills are 4-2 ATS as home favorites in the 2024 season.
Patriots are 3-4 ATS as road dogs in the 2024 season.
OVER is 9-5 in the 14 games for both teams in 2024.

Bills vs. Patriots Series History

Last meeting:
Patriots 21, Bills 27: December 31, 2023: Week 17 – Highmark Stadium, Orchard Park, NY

Head-to-head (includes postseason games):
New England Patriots lead series 78-50-1

The #Bills are debuting a new uniform this week vs the #Patriots. pic.twitter.com/Sd7GWJKRLj
— New England Sports Fellow (@NESportsFellow) December 17, 2024