The roar of the NFL crowd is just around the corner, with the first games of the season kicking off in a little over two months! With the draft concluded, excitement is building for training camp and the highly anticipated Week 1 matchups.
To get you prepped for the season ahead, we’re diving into our NFL Week 1 SU Picks, analyzing potential upsets and early favorites.
2024 NFL Week 1 SU Picks | MyBookie NFL Preview of the First Week of the Season
2023 NFL season | 104th season of National Football League in the United States
September 7, 2023–February 11, 2024
Kansas City Chiefs over Baltimore Ravens
No Super Bowl hangover for Kansas City.
They have won back to back, and now will start the season against the team they beat to get to the big game.
Patrick Mahomes and Travis Kelce come out guns a blazin and beat Lamar Jackson and his Ravens squad.
Philadelphia Eagles over Green Bay Packers
This game will be played in Brazil. The first Friday Night Football game.
The Eagles have a ton to prove this season after falling flat last season.
We like Philadelphia to keep Jordan Love and the Packers offense under control, and using Hurts and company to get on the board.
Take the Eagles over the Packers.
Atlanta Falcons over Pittsburgh Steelers
What an interesting National Football League game to start the season.
The Atlanta Falcons could be starting Kirk Cousins and the Pittsburgh Steelers could be starting Russell Wilson or Justin Fields.
Both teams had a bunch of turnover in the off-season.
We like Cousins to come out strong and win his debut in Atlanta.
New York Giants over Minnesota Vikings
Two rebuilding teams. The Giants get the home game in Week 1. Vegas oddsmakers have placed this game at a pick’em. Two teams where we have a ton of question marks on.
In the end, we like the home team, and Daniel Jones to grab an ugly Week 1 win over the Minnesota Vikings.
Miami Dolphins over Jacksonville Jaguars
The battle of Florida belongs to the Dolphins. Miami should still be really good on the offensive side.
The Dolphins know the season is a long one, so starting out red hot does not always lead to great things at the end of the season.
Look for the talented Miami offense to shine at home over the Jaguars.
Cincinnati Bengals over New England Patriots
This has the potential of being the biggest blowout in Week 1 of the NFL season.
Joe Burrow and company are ready to have a monster bounce back season.
The Patriots are among the worst teams in the National Football League.
All Cincinnati, all the time in this game on Sunday afternoon.
Buffalo Bills over Arizona Cardinals
Buffalo will have a new look, but still very talented. We like the Bills here at home.
Josh Allen wants to make sure he is still in the picture as far as the elite quarterbacks in the AFC.
The MVP picture should still have Allen’s name being mentioned.
Buffalo passes the first test of the season and beats the Cardinals at home.
Houston Texans over Indianapolis Colts
CJ Stroud and the Houston Texans have a ton of hype for them starting the season.
We like them to live up to the hype in Week 1.
This game has the makings of a thriller in Indianapolis.
In the end, too many weapons for Indianapolis to contend with, as the Texans beat the Colts to start the AFC South season.
Chicago Bears over Tennessee Titans
Starting a rookie quarterback in Week 1 is the Chicago Bears.
Caleb Williams, following his time at USC is ready for the big show.
He gets a pretty weak Tennessee team to start it out. We like Williams and some of his new weapons.
We are going to take the Bears to start hot and win in Week 1.
New Orleans Saints over Carolina Panthers
There will not be many opportunities that we take the Carolina Panthers to win.
The worst team in the league a season ago, and should be right there again this season.
Take the Saints over the Panthers in Week 1.
Los Angeles Chargers over Las Vegas Raiders
In a battle of AFC West teams, Coach Harbaugh is going to have a Chargers roster that will look different than the previous seasons.
But, this roster should be able to play hard, play smart and play together.
The previous Chargers rosters had a hard time putting all those things together.
The Chargers grab a big divisional win to start their season and beat the Raiders.
Dallas Cowboys over Cleveland Browns
We like the Cowboys and their talent to go on the road and beat the Browns.
The Browns have some questions to answer before we put them back in the same level as they were a season ago.
Were the Browns as good as they played or did they play a little above their talent?
We will find out, but for now, we like Dallas in Week 1.
Detroit Lions over Los Angeles Rams
The Jared Goff vs. Matthew Stafford game.
The Lions are one of the biggest threats in all of the NFC this season.
Detroit’s offense, piece by piece is one of the best in the league.
In Detroit, on Sunday Night Football, we like Dan Campbell’s team to win this game.
The Rams are a mystery team this season, so it will take us some time to get a true gauge on them.
San Francisco 49ers over New York Jets
The big story here will be how long Aaron Rodgers can last in the first game of the season?
The bigger question is – do the Jets really think he can last all season?
The 49ers are going to be back to being an elite level football team.
The 49ers just do not have many holes.
Look for them to show up and show out on Monday Night Football and smash the Jets.
Other Week 1 Winners:
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Seattle Seahawks over Denver Broncos
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Tampa Bay Buccaneers over Washington Commanders
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There you have it. Those are our National Football League Week 1 Straight Up Picks. We cannot wait for the start of the season, and hope you are excited as well. Good luck with all your National Football League bets!
The following NFL betting odds are based on MyBookie Sportsbook.
2025 NFL Conference Championship
See who clashes in the opening act of the NFL season with this Conference Championship game schedule.
| Matchup | Time | TV | Location | |
|---|---|---|---|---|
| Sunday, February 9, 2025 | ||||
| Super Bowl Sunday | ||||
| Kansas City | @ Philadelphia | 6:30 PM | FOX | Caesars Superdome, New Orleans, LA |
| Betting Lines for NFL Games | Conference Championship Games of the NFL Season | ||||
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