NFL Week 10 Odds: Must Bet Games and Expert Analysis

We saw Week 9 close out with another Monday night thriller, which saw the Kansas City Chiefs maintain their perfect record after taking down the Tampa Bay Buccaneers in OT.

We are now about to head into Week 10, where there are once again some big games that could potentially have an impact on the divisional standings and the playoff picture.

My NFL Week 10 Must Bet Games Analysis

Yes, there is still a lot of football to come, but we are now at the stage of the season where we need to start looking at the playoff standings and all the tiebreakers that will eventually determine which teams will still be playing beyond the end of the regular season.

We have 6 games in Week 10 picked out that we really like, so let’s take a closer look, with the odds for each listed, too.

Keep in mind that these odds might change as the week progresses.

TNF Cincinnati Bengals +204 at Baltimore Ravens -260

Thursday, November 7, 2024, 8:15 PM, Prime Video | M&T Bank Stadium, Baltimore, MD

The new week begins on Thursday night with a huge AFC North Division matchup that is basically a must-win for both teams given that the Pittsburgh Steelers are currently in control of the top spot.

If truth be told, the Bengals need this one more, as they are trying to dig their way out of an early season hole.

Chase was on the case!!@chasebrown____ x #RuleTheJungle pic.twitter.com/GM6wu8Kte8
— Cincinnati Bengals (@Bengals) November 5, 2024

The Bengals are coming off a win that moved them to 4-5, so they still have some work to do to get back into the playoff picture.

The Ravens have looked very good for large portions of the season, but they have also had moments where you begin to question everything.

Still, they are 6-3 this season and could take back control of the North with a win and a Steelers loss this weekend.

The Ravens are favored by 6, with the total set at 52 ½.

Denver Broncos +320 at Kansas City Chiefs -429

Sunday, November 10, 2024, 1:00 PM, CBS | GEHA Field at Arrowhead Stadium, Kansas City, MO

It might be foolish to declare a division winner with so many games still to be played, but it is looking as though the Kansas City Chiefs, who are 8-0, are going to run away with the AFC West.

With that in mind, the Broncos really need a win if they are to stay in with a shot at closing the gap, or perhaps just nabbing themselves a Wild Card spot.

The Broncos lost this past weekend, which dropped them to 5-4 overall and 3rd in the division, but can they take advantage of a Chiefs team on a quick turnaround?

While the Chiefs may still be undefeated, they have not looked totally unbeatable, so this is by no means a total slam dunk.

The Chiefs are favored by 9 ½, with the total set at 41 ½.

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NFL Week 10 Must Bet Games provided by MyBookie

San Francisco 49ers -236 at Tampa Bay Buccaneers +188

Sunday, November 10, 2024, 1:00 PM, FOX | Raymond James Stadium, Tampa, FL

Last season, the San Francisco 49ers went all the way to the Super Bowl, eventually losing to the Chiefs, and many people believed that they were a good pick to repeat that run and perhaps go one better and win it all.

It has been a struggle for the 49ers, though, thanks in large part to not having Christian McCaffrey available all season long.

They are at 4-4, and while that is well off the pace we expected from them, the good news is that the division as a whole is sitting around the .500 mark, with the Cardinals leading the way at 5-4.

The Buccaneers have been highly competitive this season, but they have now lost 3 in a row to fall to 4-5.

The 49ers will hit the road as a 6 ½ point favorite, with the total for this one set at 51.

Pittsburgh Steelers +129 at Washington Commanders -159

Sunday, November 10, 2024, 1:00 PM, CBS | Northwest Stadium, Landover, MD

The Pittsburgh Steelers took a real risk this offseason, totally blowing up their QB room and bringing in 3 new QBs, with Russell Wilson and Justin Fields competing for the number 1 spot.

Fields won out, largely due to a minor injury to Wilson, and led the team to a 4-2 start before a switch was made and Wilson was put in place as the starter.

He has won both his games, taking the Steelers to 6-2, which has them sitting atop the AFC North, slightly ahead of the Ravens.

The Steelers are about to enter a crazy stretch of games that will see them play 6 divisional matchups down the stretch.

The Commanders are also something of a surprise this season, with much of the credit going to rookie QB Jayden Daniels, who has been nothing short of brilliant in leading his team to a 7-2 record.

The question now is how he will handle what is, quite possible, the best defense in the league.

Washington is favored by 2 ½, with the total set at 46.

Philadelphia Eagles -380 at Dallas Cowboys +285

Sunday, November 10, 2024, 4:25 PM, CBS | AT&T Stadium, Arlington, TX

Prior to the start of the season, a lot of us probably looked at this game and thought it would be a battle for the top spot in the division.

The Philadelphia Eagles have certainly held up their end of the bargain, coming into this game with a 6-2 record, which has them hot on the heels of the Commanders at the top of the NFC East.

They are hot now and come into this game on a run of 4 straight wins.

On the flipside, the Dallas Cowboys are sinking like a stone, losing 3 in a row to fall to 3-5.

Cowboys QB Dak Prescott expected to miss multiple weeks due to hamstring injury. (via @rapsheet, @tompelissero) pic.twitter.com/aeQumpKs4d
— NFL (@NFL) November 4, 2024

Their home stadium, which used to be a fortress, is no longer that formidable, with the Cowboys going 0-3 at home this season. Probably no real surprise that Philly is favored by 7 ½.

The point total for this one is set at 42.

SNF Detroit Lions -189 at Houston Texans +153

Sunday, November 10, 2024, 8:20 PM – NBC, Peacock | NRG Stadium, Houston, TX

Living up to expectations can be tough for any team, but for one like the Detroit Lions, who were in the cellar for a long period of time, it is trickier still.

They had a breakout season last year, setting the bar even higher for this season, with some fans suggesting that this team might not be as good as advertised.

The Lions have proven that they are indeed that good, winning 6 in a row to move to 7-1 this season, which includes a perfect 4-0 road record.

The Texans are another team that saw expectations raised with a great first season with CJ Stroud under center.

They are doing well, sitting at 6-4 after losing last weekend, which has them slightly ahead in the AFC South.

Detroit is a 3-point road favorite, with the total set at 49 ½.