NFL Week 18 Odds: QB Matchups Betting Predictions and Picks for Every Game

The final week of the NFL regular season is here and with it, betting NFL Week 18 Quarterbacks picks from MyBookie takes center stage, with several key quarterback matchups influencing playoff scenarios.

2024 NFL Week 18 Picks for the Top Quarterback Matchups
Betting on the Stars: Week 18 Quarterback Showdowns

2024 NFL season | 104th season of National Football League in the United States
Week 18: Saturday, January 4th – Sunday, January 5th, 2025

Betting NFL Week 18 Quarterbacks Picks

A lot of the best quarterbacks in the NFL will take a seat this week.

Patrick Mahomes, Josh Allen, and Lamar Jackson aren’t likely to play in NFL Week 18.

Quarterbacks like Minnesota’s Sam Darnold and Detroit’s Jared Goff, though, should suit up.

If something is at stake, like a division title or a wild card playoff berth, the starting QB will play.

Check out a list of games along with quarterback picks for the most likely relevant matchups in NFL Week 18.

Writer’s NFL Quarterback Picks for the Week 18 Matchups

Carolina – Bryce Young at Atlanta – Michael Penix Jr.

Sunday, January 5th, 2025

Penix Jr. has the ability to really disrupt a Carolina Panthers’ defense that although plays hard doesn’t have to the talent to stop top offenses.

But Carolina struggles against the rush.

So Atlanta is likely, like what they’ve done since Penix Jr. got the starting call, to lean on Bijan Robinson.

Bryce Young is turning into a Kyler Murray clone.

He’s becoming one of the more solid starting quarterbacks in the NFL.

Young posts the better stats even though the ATL should win this.

NFL Week 18 QB Pick: Bryce Young

Minnesota – Sam Darnold at Detroit – Jared Goff

Sunday, January 5th, 2025

Darnold versus Goff could be for the NFC North title as well as the top seed in the NFC Playoffs.

Darnold has been unreal this season.

He’s clicked with Justin Jefferson and Jordan Addison.

Goff, though, takes on the rival Vikings on his turf.

Also, Goff has a secret weapon in running back Jahmyr Gibbs to go along with a pair of stretch the field receivers in Amon-Ra St. Brown and Jameson Williamson.

JG posts the better stats than Darnold.

NFL Week 18 QB Pick: Jared Goff

Seattle – Geno Smith at LA Rams – Matthew Stafford

Sunday, January 5th, 2025

Both quarterbacks lean on a top rushing attack.

The difference is that Stafford has two WR1s in Puka Nacua and Cooper Kupp.

Also, Stafford’s running back, Kyrene Williams, is one of the top pass catchers out of the backfield.

However, this game will be tough because the defenses for both teams have stepped up in recent weeks.

Staff and the Rams have the edge on the scoreboard.

Geno can win the duel he’s got with Stafford.

NFL Week 18 QB Pick: Geno Smith

San Francisco – Brock Purday at Arizona – Kyler Murray

Sunday, January 5th, 2025

Purdy is playing for an extended contract.

So we should expect the San Francisco quarterback to step onto the field even though SF has been eliminated from playoff contention.

The Arizona Cardinals won’t make the playoffs either.

But the Cards have homefield and Kyler has more weapons in this than Purdy.

Even if James Conner doesn’t play, Murray can turn to McBride or Harrison.

There’s also Michael Carter and Murray is a master at using his legs.

NFL Week 18 QB Pick: Kyler Murray

Cincinnati – Joe Burrow at Pittsburgh – Russell Wilson

Sunday, January 5th, 2025

A lot could be at stake for Joe Burrow, Ja’Marr Chase, and the Cincinnati Bengals.

A lot will also be at stake for Russell Wilson and the Pittsburgh Steelers.

The Steelers have a shot to win the AFC North.

If Pittsburgh beats Cincinnati and the Ravens fall to the Browns, Steel Town takes the division.

But Joe Burrow will be fighting for a playoff spot.

So we should expect the Bengals’ star QB to exact revenge on Wilson and the Steelers after losing the earlier season shootout.

NFL Week 18 QB Pick: Joe Burrow

Miami – Tua Tagovailoa at NY Jets – Aaron Rodgers

Sunday, January 5th, 2025

In what could be Aaron Rodgers’ final NFL game, the Jets hope to end the season on a high note when they take on Tua Tagovailoa and the Miami Dolphins.

The Fins are likely to be playing for nothing.

Tua doesn’t do well on the road.

He also doesn’t play that well in the cold and both Tyreek Hill and Jaylen Waddle have nagging injuries.

Rodgers lights up the Miami secondary.

NFL Week 18 QB Pick: Aaron Rodgers

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Tua Tagovailoa in games against teams with a record over .500 pic.twitter.com/nNn0luTLej

— Zach 🌎 (@zzachary_1) December 15, 2024

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