NFL Week 10 Odds: Quarterback Matchups Key Battles

This week’s top NFL quarterback matchups feature exciting duels that could impact the NFL betting line, starting with a significant game between Joe Burrow and the Cincinnati Bengals facing off against Lamar Jackson and the Baltimore Ravens. Other notable signal-caller matchups include Bo Nix and the Denver Broncos taking on Patrick Mahomes and the Kansas City Chiefs, as well as Brock Purdy of San Francisco heading to Florida to challenge Baker Mayfield and the Buccaneers.

2024 NFL Week 10 Quarterback Matchups
Week 10 QB Showdown: Who Will Reign Supreme?

2024 NFL season | 104th season of National Football League in the United States
Week 10: Thursday, November 7th – Monday, November 11th, 2024

Betting Week 10 NFL Games

This week’s top NFL quarterback matchups start with a huge game between Joe Burrow and the Cincinnati Bengals and Lamar Jackson and the Baltimore Ravens.

Other top signal caller duels in NFL Week 10 include Bo Nix and Denver taking on Patrick Mahomes and Kansas City and San Francisco’s Brock Purdy heading to Florida to throw down against Baker and the Bucs.

Check out this week’s best NFL quarterback matchups.

Writer’s NFL Quarterback Picks for the Week 10 Matchups

Cincinnati – Joe Burrow at Baltimore – Lamar Jackson

Thursday, November 7th, 2024

Joe Cool versus Lamar is one of the top quarterback matchups in the league.

The two have been going at it for about four years now with, often, Burrow winning the duel.

Not this time. The game happens in Baltimore and Lamar is working on a third MVP.

Jackson is playing lights out.

As crazy as it sounds, Lamar is having the best NFL season of his career, which says a lot considering he’s won two NFL MVPs already.

Lamar beats Joe Cool on the stat sheet.

NFL Week 10 QB Pick: Lamar Jackson

Denver – Bo Nix at Kansas City – Patrick Mahomes

Sunday, November 10th, 2024

Patrick Mahomes and the Kansas City Chiefs are the favorites to repeat as Super Bowl Champions but it’s not because of Patrick’s ability to throw TDs.

Yes, Mahomes is the leader of the team but if wasn’t for KC’s defense, the Chiefs might not be a .500 team.

On Sunday, Mahomes faces one of the best defenses in the NFL.

Denver is putting the clamps on every offense it faces.

Almost as important is that the light bulb has gone off in Bo Nix’s head.

Nix is finally understanding what Sean Payton expects.

Nix, not as surprisingly as one might believe, wins the matchup.

NFL Week 10 QB Pick: Bo Nix

San Francisco – Brock Purdy at Tampa Bay – Baker Mayfield

Sunday, November 10th, 2024

Purdy and the Niners are trying to make a late season move to win the NFC West, make the playoffs, and return to the Super Bowl.

But the 49ers are more than Purdy.

Kyle Shanahan believes in using the running game as much as letting Purdy light up opposing defenses.

In this case, Tampa’s horrid secondary, which pretends to defend against the pass should help Purdy post big stats.

However, Baker is having a nice season.

Also, Tampa’s lone hope of winning is to unleash Mayfield and his bevy of targets, especially tight end Cade Otten, who is close to uncoverable.

Baker gets the nod over Brock.

NFL Week 10 QB Pick: Baker Mayfield

Philadelphia – Jalen Hurts at Dallas – Dak Prescott

Sunday, November 10th, 2024

In any other season, Hurts versus Prescott would be the quarterback matchup of the week.

This season, Hurts is playing second fiddle to running back Saquon Barkley, which appears fine by Jalen.

Barkley will be the story in this.

What it means is Prescott posts the better stats but the Eagles win outright because Dallas can’t stop the run.

NFL Week 10 QB Pick: Dak Prescott

NYJ – Aaron Rogers at Arizona – Kyler Murray

Sunday, November 10th, 2024

Murray versus Rogers should be a great matchup.

Kyler can beat any defense.

Ah, but the Jets are a different D with Haason Reddick, one of the best defensive ends in football in the past five seasons.

Rogers is clicking with both Davante Adams and Garrett Wilson.

If Breece Hall gets involved, Aaron will have an even bigger night.

Murray faces too much pressure in this one.

Rogers leads the Jets to a win while posting the better stats.

NFL Week 10 QB Pick: Aaron Rogers

Detroit – Jared Goff at Houston – C.J. Stroud

Sunday, November 10th, 2024

Goff versus Stroud looks like a competitive matchup on paper.

It will be interesting and Houston can beat Detroit but only one of these quarterbacks is dominating the stat sheet.

That QB is Jared Goff.

The former Cal Bear and LA Ram is having a banner season.

He’ll put a whipping onto the Houston Texans’ defense that has given up big yards and long touchdowns to opposing quarterbacks this season.

NFL Week 10 QB Pick: Jared Goff

Miami – Tua Tagovailoa at LAR – Matthew Stafford

Monday, November 11th, 2024

Tua probably shouldn’t be playing football.

Yes, like Tua said, it’s a personal decision.

After multiple concussions even the great Carolina linebacker Luke Kuechly retired.

Tagovailoa should really consider hanging up the cleats.

In any case, Matthew Stafford is the best quarterback in the NFC when Puka Nucua, Cooper Kupp, and Kyrene Williams are all on the field.

The Rams will dominate this game from the outset and Staff will post another multiple TD throwing game.

NFL Week 10 QB Pick: Matthew Stafford

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MATTHEW STAFFORD TO WIN THE GAME!#LARvsSEA on FOX#GoDawgs | #DawgsInTheNFL
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— Georgia Football (@GeorgiaFootball) November 4, 2024

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