There is a very fine line between winning and losing in the NFL, such as the level of parity in the league. We have seen a lot of games go down to the wire this year, and while that is great for fans who watch the games, it can make things a little stressful for those of us who wager on them, such as the NFL Week 10 betting lines reflect.I do love a challenge, though, which I why I always look forward to the NFL Odds for each week. Even if you are coming off a bad week with your picks, you quickly get another chance to pick a bunch of winners and make things right. We will have a ton of Week 10 NFL picks for you to look at, but let’s get things started by identifying some potential Straight-Up winners.
Things don’t look as though they are about to get any brighter for the Texans this weekend, as they will be going up against an LA Rams team that is scoring just for fun. I just don’t see Houston being able to hang with that Rams defense, which is why I think LA is a rather safe bet SU.
Top Straight-Up NFL Week 10 Betting Picks
Matthew Stafford’s 132.4 QB rtg Monday night marked the second-highest passer rating by visiting QB in Lambeau Field history (min. 20 att). pic.twitter.com/6nx4azkUSA
— Detroit Lions (@Lions) 7 de noviembre de 2017
Best NFL Week 10 Matchups & Expert Picks
Detroit Lions over Cleveland Browns
- When: Sunday, November 12, 1:00 p.m.
- Where: Ford Field, Detroit
Latest NFL Week 10 Betting Trends
- Browns are 0-5 SU in their last 5 games
- Browns are 0-5 SU in their last 5 games on the road
- Lions are 2-4 SU in their last 6 games
- Lions are 1-4 SU in their last 5 games at home
New York Jets over Tampa Bay Buccaneers
- When: Sunday, November 12, 1:00 p.m.
- Where: Raymond James Stadium, Tampa Bay
Latest NFL Week 10 Betting Trends
- Jets are 8-15 SU in their last 23 games
- Jets are 5-0 SU in their last 5 games when playing Tampa Bay
- New York is 1-4 SU in its last 5 games on the road
- Buccaneers are 0-5 SU in their last 5 games
- Buccaneers are 6-2 SU in their last 8 games at home
Los Angeles Rams over Houston Texans
- When: Sunday, November 12, 4:05 p.m.
- Where: Memorial Coliseum, Los Angeles

Latest NFL Week 10 Betting Trends
- Texans are 2-4 SU in their last 6 games
- Texans are 1-4 SU in their last 5 games on the road
- Rams are 5-1 SU in their last 6 games
- Rams are 2-9 SU in their last 11 games at home
New England Patriots over Denver Broncos
- When: Sunday, November 12, 8:30 p.m.
- Where: Mile High Stadium, Denver
Latest NFL Week 10 Betting Trends
- Patriots are 5-0 SU in their last 5 games on the road
- Patriots are 6-3 SU in their last 9 games when playing Denver
- Broncos are 1-5 SU in their last 6 games
- Broncos are 4-1 SU in their last 5 games at home
- Denver is 15-4 SU in its last 19 games when playing at home against New England