Cardinals vs Panthers Odds Analysis for Week 4 of the 2022 NFL Season

Cardinals vs Panthers Odds Analysis for Week 4 of the 2022 NFL Season

A couple of teams hoping to climb to .500 clash on Sunday when Baker Mayfield and the Carolina Panthers host Kyler Murray and the Arizona Cardinals. The Panthers enter Bank of America Stadium a slight -1.5 chalk. Will Kyler and the Cards take it to Baker and his mates? Or will Arizona get it done? Keep reading for NFL Odds, analysis, and a free pick for Arizona at Carolina. 

NFL Week 4 Betting Preview for Arizona Cardinals at Carolina

Arizona versus Carolina Odds and Game Info

  • When: Sunday, Oct. 2 at 4:05 pm ET 
  • Where: Bank of America Stadium, Charlotte, NC
  • TV / Streaming: FOX / Fox Sports
  • ATS Odds: Carolina -1.5    
  • Over/Under Odds: 43.5   

Why bet on Arizona versus Carolina?

The Cardinals have been up and down so far, but outside of their first game, where Patrick Mahomes and the Chiefs jumped all over the Cards, AZ has played competitive ball. Mental mistakes cost them versus the rival Rams but if Zona goes back to their week 2 performance, they should win this game. 

Arizona Cardinals Offensive Averages

  • Total Yards: 353.3
  • Passing Yards: 248.0
  • Rushing Yards: 105.3
  • Points Scored: 20.7
  • Turnovers: 1

Arizona Cardinals Defensive Averages

  • Total Yards: 383.7
  • Passing Yards: 281.0
  • Rushing Yards: 102.7
  • Points Scored: 29.0
  • Takeaways: 3

Why bet on Carolina versus Arizona?

Often an NFL team requires one good victory to turn things around. The Panthers one good win may have happened in NFL Week 3 when they dusted the rival New Orleans Saints. Carolina not only hung 22 onto a Saints’ defense that many believed was one of the best in the league, but the Panthers held New Orleans to 14 points. If Carolina repeats their last effort on Sunday, the Panthers will win and cover.  

Carolina Panthers Offensive Averages

  • Total Yards: 276.3
  • Passing Yards: 161.3
  • Rushing Yards: 115.0
  • Points Scored: 20.7
  • Turnovers: 3

Carolina Panthers Defensive Averages

  • Total Yards: 348.7
  • Passing Yards: 214.0
  • Rushing Yards: 134.7
  • Points Scored: 19.7
  • Takeaways: 3

Cardinals at Panthers Relevant Trends

  • Cardinals are 1-5 ATS in their last 6 games on grass
  • Arizona is 7-1 ATS in their last 8 games in October
  • Under is 14-3 in the Cardinals’ last 17 games following an ATS loss
  • Panthers are 3-14 ATS in their last 17 games overall
  • Carolina is 1-6 ATS in their last 7 versus the NFC 
  • Under is 4-1 in the Panthers’ last 5 versus the NFC 

Arizona Cardinals at Carolina Panthers Final Betting Prediction

It’s tough to back either one of these teams, but 2 powerful trends push us towards going with Kyler and the Cardinals. First, Arizona is 7-1 against the spread in their last 8 in October.

The trend implies Zona coaches make key adjustments after games in September. The second trend is the Panthers going 1-6 ATS in their last 7 versus the NFC. 

This trend tells us Carolina beat the Saints last week but the win was an anomaly. Looking further in the Panthers’ past performances, Carolina beat New Orleans early at home last season as well.

The Panthers might be one of those teams that performs great against a single opponent, the Saints, but fails versus everyone else. Arizona has more talent and played well against the Rams in their last. Murray and his mates get the ATS nod.   

NFL Week 4 Pick: Arizona Cardinals +1.5 


I have read enough, I need to place my bet now. What to do?

Bet NFL Today
MyBookie Betting Lines for the bout


NFL Betting Center

Updated NFL Odds | Online Sports Betting