MLB 2022 Chicago White Sox vs Chicago Cubs Betting Analysis & Pick

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One of the best additions to baseball in recent years has been interleague games, where we get to see matchups that would previously have never happened outside of the World Series. There is sure to be some series buzz in Chicago right now, as we are looking at 4 games between the White Sox and the Cubs this season, with the first of those set to go on Tuesday night. Both of these teams could use a bit of a shot in the arm, so a set of games against a cross town rival might be just what the doctor ordered for these guys. For the purposes of this MLB Betting analysis piece, we are going to jump ahead to Wednesday night and the 2^nd of the 2-game series, so let’s take a closer look at that one.

Baseball Preview and Analysis for Chicago White Sox at Chicago | MLB Betting

Chicago White Sox at Chicago Game Info

When: Wednesday, May 4 at 7:40 PM EST
Where: Wrigley Field, Chicago
Watch: NBCSCH, Marquee Sports Newtwork
Starting Pitchers: Lucas Giolito Vs Kyle Hendricks

Why bet on the Chicago White Sox

The Chicago White Sox came into the season as the favorites to win the AL Central, but they have seen their season get off to a slow start to this point. The White Sox come into this mini-series with a record of 9-13, which has them 4 ½ games out of the lead in the division. They have gone just 3-7 in their last 10 games and have been struggling to put runs on the board from the off. They are, though, coming off a 3-0 win over the Angels and will be looking to build some momentum against their city rivals. This may be what the doctor ordered for the White Sox, as they have thrived in interleague play, winning 10 of their last 11. That includes winning 4 in a row against teams with a losing record. The OVER is 5-0-1 in their last 6 interleague games versus a lefty starter. Lucas Giolito (0-1, 2.57 ERA) will get the start.

Why bet on the Chicago Cubs

The feeling heading into the new season was that this had the potential to be a rather long, painful year for the Chicago Cubs. While things are perhaps not as grim as some expected in the early going, the Cubs are already well off the pace being set at the top of the NL Central. In terms of offense, the Cubs have actually not been that bad this season, but they have been unable to produce on the defensive side of the baseball. They come into this one on the heels of a win, but they are also just 3-7 over the course of their last 10 games. If we do a real deep dive into the Cubs in interleague play, we see that they have a respectable 41-20 record in interleague games versus teams with a losing record. In their last 5 interleague games versus a right-handed starter, the OVER has hit all 5 times. Kyle Hendricks (1-2, 5.47 ERA) gets the ball for the Cubs.

Expert Pick and Final Score Prediction

The one thing that jumps out here when looking at the trends is that we are probably looking at some runs hitting the board, which is why I am leaning OVER in this one. I also like the White Sox to come away with the win.

MLB Betting Pick: Chicago White Sox 6 Chicago Cubs 4

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