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The college basketball regular season and conference tournaments are all over with now, which means it’s time to look ahead to March Madness. We will have 4 play-in games over the next couple of days before we get to the tournament proper, so we still have some time to break things down as we all try to win some money and create the perfect bracket. As always, the tournament is split into 4 distinct regions, which means no less than 4 #1 seeds looking to make a deep run and win it all. We will cover as much ground as possible throughout the course of the tournament, but let’s get things rolling by taking a closer look at the South Region so you can place your bets against the March Madness Betting Odds.

Top South Region Bracket Betting Predictions for the Upcoming Games

South Region Favorites

The Arizona Wildcats had themselves a great season, winning the PAC 12 regular season crown as well as the conference tournament. They are more than deserving of the #1 seed in the South Region and are the favorites to get out of what looks to be a very tough region. Their toughest test might not come until the Sweet 16, when they could potentially face #5 Houston, although you never really know how things might play out along the way.

The Villanova Wildcats won the tournament in 2016 and 2018 and are once again looking to make another deep run. This team certainly looks equipped to make a run after winning the Big East without breaking too much of a sweat. Their tournament begins with a game versus Delaware, after which they could potentially face Ohio State, although we will have more on that in a minute. With their pedigree, it’s tough to bet against Villanova.

Potential Dark Horses and Upset Specials

There are some who think that the Tennessee Volunteers are ranked a little too high in the #3 spot, but they finished the season on a tear and ended up closing things out as the SEC champion. They have a pretty manageable path ahead of them, although you do have to say that their opening round game against Winthrop has the potential to be a tricky one. They should get past that game, though, and move on to Round 2.

It’s always fun to try and pick out the bracket busters before the ball gets rolling, and we certainly have one of those in the South Region. Loyola Chicago has very much become a fan favorite of the last couple of years and have won at least 2 games in each of their last 2 tournament appearances. They are in as the #10 seed in the South Region and will open against #7 Ohio State. Given what Loyola Chicago has done in the past, it would not be a big surprise to see them knock off the Buckeyes.

Who Wins the South Region?

This is going to be a tough region to get out of, but one teams appears to have what it takes to do it. I am talking about #2 Villanova, who I like to survive and move on to the Final Four 4.