Best 2022 NFL Week 12 Games to Bet On, Early Analysis, and Picks

Best 2022 NFL Week 12 Games to Bet On, Early Analysis, and Picks

Three NFL games take place on Thanksgiving Day this week. Of the three, the most intriguing matchup pits the New England Patriots versus the Minnesota Vikings. Then on Sunday, Nov. 27, the Tampa Bay Buccaneers head to Cleveland to battle the Browns in what could be Deshaun Watson’s first game of the season. See below for analysis and free NFL Betting picks for six of the best matchups in NFL Week 12. 

Must Bet Games in Week 12 of the 2022-23 NFL Season

2022 NFL Week 12

  • When: Thursday, Nov. 24 – Monday, Nov. 28

New England Patriots at Minnesota Vikings | Thursday, Nov. 24

The Patriots will lean on their defense this season. The Vikings will lean on their offense. For sure, Minnesota’s offense is better than New England’s.

But by week 12, the Pats should have a solid, balanced, offense that will put points on the board and control clock. The Patriots will have a shot at the money line upset win. 

NFL Week 12 Pick: New England Patriots  

Tampa Bay Buccaneers at Cleveland Browns | Sunday, Nov. 27

Cleveland fans are going to be super excited when Deshaun Watson finally steps onto the field. But even if Deshaun plays, Cleveland will lean on a decent pass rush. 

Here’s the thing with this game. By the twelfth week, Tampa will have solved their offensive line problems. Tom Brady and the Buccaneers get the win and cover. 

NFL Week 12 Pick: Tampa Bay Buccaneers  

Los Angeles Rams at Kansas City Chiefs | Sunday, Nov. 27

Rams versus Chiefs in NFL Week 12 projects as a possible Super Bowl 57 matchup. The Chiefs should be the chalk, but before dumping on KC, it’s important to note that by week 12, the Rams’ defense should be one-hundred percent.

Aaron Donald, Leonard Floyd, and Jalen Ramsey will contain Patrick Mahomes. Expect the Rams to make a statement in this one. 

NFL Week 12 Pick: Los Angeles Rams 

New Orleans Saints at San Francisco 49ers | Sunday, Nov. 27

The 49ers made one of the smartest moves in the past few seasons. Instead of cutting Jimmy Garoppolo, the Niners asked Jimmy G. if he would restructure his contract. 

Garoppolo said no problem. SF will play Jimmy if Trey Lance doesn’t work out. San Francisco should be one of the top teams in the NFL this season. But beating the Saints won’t be easy. New Orleans D is fantastic and the offense has the chance to average a lot of points.  The Saints will be worth a look. 

NFL Week 12 Pick: New Orleans Saints   

Green Bay Packers at Philadelphia Eagles | Sunday, Nov. 27

One of NFL Week 12’s most important games projects as Eagles hosting Packers. It’s difficult to know what happens this contest.

One thing we do know is that no matter what happens, Aaron Rodgers will find a way. So right now, Green Bay is the pick to upset Philadelphia straight up on the road. 

NFL Week 12 Pick: Green Bay Packers 

Pittsburgh Steelers at Indianapolis Colts | Monday, Nov. 28

If things work out for Indianapolis, by Nov. 28 the Colts will have around a 4 game lead in the AFC South, Matt Ryan will be an NFL MVP contender, and the Indianapolis defense will rank in the top 5 in total yards allowed.

If things work out for Pittsburgh, the Steelers will be on the cusp of a wild card playoff spot. Pittsburgh should be a decent team. But they won’t have much of a chance against Matty Ice and the Colts in a Monday night tilt. 

NFL Week 12 Pick: Indianapolis Colts


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