2022 U.S. Open Cup Round of 16 Matches to Bet On Wednesday

2022 U.S. Open Cup Round of 16 Matches to Bet On Wednesday

The United States Open Cup Round of 16 happens on Wednesday, May 25. Odds in most games suggest competitive matches. Inter Miami and Orlando City kick off the festivities at 7:00 pm eastern time. Check out US Open Cup Odds on MyBookie, analysis, and free picks for six U.S. Open Cup Round of 16 matches. 

Soccer Betting Preview for the U.S. Open Cup May 25th Games

Inter Miami CF +340 vs Orlando City SC -156

  • When: Wednesday, May 25 at 7:00 pm ET

No doubt, Orlando City should be the chalk in this game, but before dumping on the home team, it’s important to note a couple of things. 

First, Inter Miami has won 2-of-4 with 2 draws. Second, in the last couple of head-to-head matches, these two have drawn. The road squad can win this straight up, but because this happens in Orlando, a third straight draw is the best play. 

Soccer Pick: Draw 

Nashville SC +106 vs Louisville City FC +224

  • When: Wednesday, May 25 at 7:00 pm ET

Until their last couple of matches, Louisville was playing like a U.S. Open Cup champ. On May 13, USL Championship rival L.A. Galaxy II beat Louisville 4-3.

Then in their next match, Louisville City fell to Monterrey Bay 2-0. MLS squad Nashville shows 3 wins, a loss, and a draw in their last 5. Although Nashville is the road squad, they’re the pick.  

Soccer Pick: Nashville SC

New England Revolution +310 vs New York City FC -143

  • When: Wednesday, May 25 at 7:30 pm ET

Both these squads are in good enough form to win this. Road team New England Revolution shows 3 wins and 2 draws in their last 5.

New York City FC has won 4 straight. 3-of-4 victories were versus MLS rivals. Not only can both teams win, but both squads offer fair odds. 

But although you can’t go wrong by choosing either to win this, New England and New York drew in the last head-to-head. Another draw seems probable. 

Soccer Pick: Draw  

Houston Dynamo +228 vs Sporting Kansas City +100

  • When: Wednesday, May 25 at 8:30 pm ET

The odds suggest Sporting Kansas City wins this. But Houston has won 3-of-4 with the lone loss happening via a 1-0 score match versus the talented Seattle Sounders.

Houston offers more than fair odds to upset the home team but Sporting KC has owned the Dynamo in the last few head-to-head matches. KC is 3-0 in the last 3. We can’t go against the home squad. 

Soccer Pick: Sporting Kansas City 

Los Angeles FC +151 vs Los Angeles Galaxy +137

  • When: Wednesday, May 25 at 10:30 pm ET

The odds in LAFC versus Galaxy don’t make a lot of sense. The Galaxy has lost 2-of-3 with a draw.

The road team in this heads into this after a 2-0 victory over the Columbus Crew in their last. Galaxy can win, but LAFC offers more profitable odds. LAFC is the play.  

Soccer Pick: Los Angeles FC 

San Jose Earthquakes +106 vs Sacramento Republic FC +214

  • When: Wednesday, May 25 at 10:30 pm ET

San Jose is on fire. The road chalk has won 3-of-5 with 2 draws. Not only that, but home team Sacramento fell to El Paso in their last soccer match.

It’s not that Sacramento Republic is a bad club. But the home team plays in the USL Championship while San Jose is an MLS squad. The Earthquakes are the pick.  

Soccer Pick: San Jose Earthquakes


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