Best NFL Week 5 Games Lines and Picks

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The Indianapolis Colts and Denver Broncos hit the gridiron on Thursday night to kick off what promises to be an excellent NFL Week 5. Top matchups include Tom Brady and the Bucs hosting Marcus Mariota and the Atlanta Falcons, the Steelers traveling to Buffalo to take on the Bills, and the Ravens throwing down against the Bengals on Sunday night. See below for NFL Odds, analysis, and free picks for NFL Week 5’s TNF, SNF, MNF games and top Sunday matchups. 

NFL Week 5 Betting Rundown for the TNF, SNF, MNF Games

2022 NFL Week 5

• When: Thursday, Oct. 6 – Monday, Oct. 10

Indianapolis Colts at Denver Broncos -3.5 | Thursday, Oct. 6

The Broncos lost running back Javonte Williams for the season but Melvin Gordon III can carry the load. Gordon III has been an RB1 for most of his career. So unless he goes down, Denver won’t see much of a running back drop off. 

Still, it’s tough to back the Broncos at -3.5 versus any team. Also, Colts quarterback Matt Ryan got it going in the second half versus the Titans last week. Yes, Indianapolis lost, but at least the offense showed some life. 

NFL Week 5 Pick: Indianapolis Colts +3.5 

Atlanta Falcons at Tampa Bay Buccaneers -8 | Sunday, Oct. 9

The good news from Tampa’s 41-31 beating they suffered at the hands of Patrick Mahomes and Kansas City this past Sunday night is that Brady and the Buccaneers’ offense finally got it going. 

The Bucs may require another offensive outburst. Atlanta is a much better team than many realize. The ATL handled the Browns in NFL Week 4. Give the Falcons a big shot to cover. 

NFL Week 5 Pick: Atlanta Falcons +8

Seattle Seahawks at New Orleans Saints -5.5 | Sunday, Oct. 9

Seattle’s offense played great versus the Detroit Lions. But we shouldn’t read too much into the win. Detroit’s defense is horrendous.

The Saints boast one of the top units in the league. Yes, even after starting out 1-3, New Orleans has one of the NFL’s best defenses.

More importantly for the Saints, the offense has a chance to get back on track at home and versus a bad Seattle defense. Also, and this is the most important part, the Saints are just a single game behind the Buccaneers and Falcons for the lead in the NFC South. N’Awlins breaks out with a blowout win. 

NFL Week 5 Pick: New Orleans Saints -5.5 

Houston Texans at Jacksonville Jaguars -7 | Sunday, Oct. 9

The Jaguars couldn’t hang with the best team in the NFL. Some, like this writer, doubted how good the Eagles were. After watching Philly beat the Jags 29-21 in a super impressive performance, it’s tough to say anything bad about the Eagles.

Jacksonville should bounce back with a big win versus the overmatched Texans. The Jaguars are the AFC South’s top team and one of the better squads in the the conference. Jacksonville covers. 

NFL Week 5 Pick: Jacksonville Jaguars -7 

Pittsburgh Steelers at Buffalo Bills -14 | Sunday, Oct. 9

Pittsburgh will start quarterback Kenny Pickett. Pickett won’t have as much success versus Buffalo’s offense as Lamar Jackson and the Ravens did when scoring 20 points.

But it’s so hard to lay 14 and Josh Allen and the Bills offense struggled versus Baltimore’s bad defense. As long as Kenny doesn’t make too many mistakes, the Steelers should keep this within the number. 

NFL Week 5 Pick: Pittsburgh Steelers +14 

San Francisco 49ers -4.5 at Carolina Panthers | Sunday, Oct. 9

Carolina is a bad football team. The coaches don’t make adjustments, Baker Mayfield doesn’t know what he’s doing, and the defense breaks down in the second half. 

There’s no way this line stays at 49ers -4.5. It might already be up 2 to 3 points. No matter. San Francisco covers.  

NFL Week 5 Pick: San Francisco 49ers 

NFL SNF: Cincinnati Bengals at Baltimore Ravens -3

The Ravens offense is fantastic, but the defense is a mess. Cincinnati finally got on track in the Tua head injury game versus Miami.

We shouldn’t expect the Ravens to bounce back after the tough loss while the extra rest days will benefit the Bengals. Cincinnati gets it done.

NFL Week 5 Pick: Cincinnati Bengals +3 

Las Vegas Raiders at Kansas City Chiefs -7.5 | Monday, Oct. 10

Raiders versus Chiefs is a rivalry game. However, Kansas City looks like a team on a mission. The Chiefs blasted the Buccaneers in their last. 

Ah, but in the NFL, teams tend to bounce after big wins. KC may not be as focused in this as they were in the smashing victory over Tom Brady and Tampa. Raiders cover. 

NFL Week 5 Pick: Las Vegas Raiders +7.5 

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