New Orleans Saints vs. San Francisco 49ers Betting Preview

New Orleans Saints vs. San Francisco 49ers Betting Preview

Written by on November 25, 2022

The New Orleans Saints (4-7) head to San Francisco to take on the 49ers (6-4) for an NFC showdown on Sunday at Levi Stadium. The Saints broke a two-game losing streak with a 27-20 win over the Rams last week; however, New Orleans has lost four of their last six games.

Meanwhile, the 49ers have started to put things together on both sides of the ball after a complete performance win over the Cardinals 38-10 on Monday night football last week.

Which NFC team will come out on top in this matchup? Let’s take a look at the Saints vs. 49ers best bets for this game and see how these two opponents stack up.

Saints vs. 49ers Week 11 NFL

Saints Hope to Build Momentum

In Week 11, the Saints defeated the Los Angeles Rams 27-20 thanks to an impressive performance from veteran quarterback Andy Dalton who tossed three touchdown passes.

In Sunday’s victory over the Rams, the Saints’ defense gave up 336 yards and 20 points, but they also managed to record four sacks. On Sunday, the Saints’ defense contributed, particularly in the second half, where they conceded just six points.

Overall, this Saints team has a ton of ground to gain if they want to potentially win the division or compete for a playoff spot. The Saints come into this matchup ranked third in the NFC South and are 1.5 games behind the Buccaneers. The offense is averaging 22.6 points, while the defense has held opponents to 24.3. 

49ers Looking Like Super Bowl Contenders

With a 38-10 victory over the Arizona Cardinals on Monday night in Mexico City, the 49ers took over first place in the NFC West. They gained 159 yards on the ground, and quarterback Jimmy Garoppolo tied his career high with four touchdown passes. 

In his best performance of the year, Garoppolo led the 49ers to an incredible victory over the Cardinals as the offense posted a whopping 38 points. He has been on fire lately, finishing with at least 130.0 for the second time in three games and recording a QB rating of 131.9. He has also gone three games without committing a turnover.

It undoubtedly helps that Garoppolo has excellent defense and offense surrounding him. The defense, in particular, has been one of the best units in the league as they rank first in yards allowed per game (283.9) and fourth in points surrendered per game (17.3). 

Betting Lines & Odds

The San Francisco 49ers enter this matchup as 9.5 point favorites (-110), according to MyBookie. In terms of the moneyline, the Saints are +315 road underdogs, while the 49ers are -435 home favorites. When it comes to the Over/Under, MyBookie has listed the total at 43 (-110).

Betting Pick

When it comes to Saints vs. 49ers best bets, take the 49ers in this matchup. Although the Saints covered the spread in their last matchup, they ran into a Rams squad that has been terrible this year. The 49ers, on the other hand, have gotten better and better each week.

San Francisco’s defense is the best in the league, and the supporting cast on offense should allow them to continue to post big numbers. The Saints are what their record says, and they simply don’t have the talent to come close in this one.

  • Prediction: San Francisco 49ers -9.5 (-110)

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