Fresh off their first loss of the season, the Arizona Cardinals head to Santa Clara on Sunday to take on NFC West rival San Francisco. The 49ers hope to win their second straight while Zona wants to get back on the winning track. Will Jimmy G. help SF cut Arizona’s close to insurmountable lead in the division? Or will the Cardinals sweep the regular season series? Check out NFL odds, analysis, and a free pick for Arizona versus San Francisco.
NFL Betting Preview for Arizona Cardinals at San Francisco
NFL Week 9 Betting | Cardinals vs 49ers Game Odds & Info
- When: Sunday, Nov. 7 at 4:25 pm ET
- Where: Levi’s Stadium, Santa Clara, CA
- TV / Streaming: FOX / Fox Sports
- ATS Odds: TBD
- Moneyline Odds: TBD
- Over/Under Odds: TBD
Why bet on Arizona versus San Francisco?
If not for a miscommunication throw from Kyler Murray to A.J. Green near the Green Bay goal line, a throw that resulted in an interception, the Cardinals might be entering their ninth game of the season with an 8-0 record. Not only did it take a pick to keep the Cardinals from beating Aaron Rodgers and the Packers. But J.J. Watt didn’t play and DeAndre Hopkins barely played. Hopkins might be one-hundred percent for this. If DeAndre is healthy, Zona has a great shot of winning this straight up.
Arizona Cardinals Offensive Averages
- Total Yards: 393.6
- Passing Yards: 264.9
- Rushing Yards: 128.8
- Points Scored: 30.8
- Turnovers: 9
Arizona Cardinals Defensive Averages
- Total Yards: 319.0
- Passing Yards: 198.9
- Rushing Yards: 120.1
- Points Scored: 17.3
- Takeaways: 14
Why bet on San Francisco versus Arizona?
It took half the season, but in NFL Week 8 the San Francisco offense clicked. SF scored 33 points in the victory over the Chicago Bears. Starting quarterback Jimmy Garoppolo threw for 22 yards. He didn’t throw a pick, but he also didn’t throw an interception. Almost as important? The Niners rushed for 145 yards from 26 carries. If SF’s offense is back on track, the 49ers can win and cover.
San Francisco 49ers Offensive Averages
- Total Yards: 369.7
- Passing Yards: 246.0
- Rushing Yards: 123.7
- Points Scored: 24.0
- Turnovers: 11
San Francisco 49ers Defensive Averages
- Total Yards: 324.0
- Passing Yards: 196.9
- Rushing Yards: 127.1
- Points Scored: 24.4
- Takeaways: 5
Cardinals at 49ers Relevant Trends
- Cardinals are 4-0 ATS in their last 4 road games
- Arizona is 5-1 ATS in their last 6 games
- Under is 4-0 in Cardinals’ last 4 games as a favorite
- 49ers are 1-6-1 ATS in the last 8 meetings
- San Francisco is 1-6 ATS in their last 6 at home
- Under is 5-0 in 49ers last 5 games following an ATS win
Arizona Cardinals at San Francisco 49ers Final Betting Prediction
At the time of this writing, San Francisco is a slight -2 favorite due to injury concerns surrounding the Desert Birds. If both DeAndre Hopkins and Kyler Murray play, the line could dramatically shift.
But even if those guys sit on the bench, San Francisco’s defense has an issue in this game. The D allowed the victory over the Chicago Bears, who might have the worst offense in the NFL, to drop 22 onto it in Week 8.
Zona averages 128.8 rushing yards per, ranking eighth in the NFL. The 49ers allow 127.1 rushing yards per game on average. If AZ gets the rushing attack going, it won’t matter if Colt McCoy is under center.
The odds have made Arizona an overlay. Expect the Cardinals, who are a play away from being undefeated, to land in SF and then fly away with a moneyline victory. If Zona ends up the chalk, they should still cover.
NFL Week 9 Pick: Arizona Cardinals