NFL Week 10 Odds & Betting Predictions: Loser Picks for this Week

NFL Week 10 Odds & Betting Predictions: Loser Picks for this Week

Written by on November 8, 2022

Week Ten is officially underway, and the early odds and lines are already out on Mybookie.

The league continues to see competitive football games, and after passing the halfway point, teams are starting to separate themselves from the weak and the strong. Who are this week’s biggest losers?

Let’s dive into some matchups and give you the best bets for week ten’s action so you can place your bets against their NFL Lines.

Who Are the Sure Losers in Week 10 of NFL Action?

Minnesota Vikings (+6.5) vs Buffalo Bills

The Vikings made the list this week despite a comeback victory over the Commanders 20-17 last week. The Vikings have put together an impressive six-game winning streak, but unfortunately for them, they will run into a Buffalo Bills team that has yet to lose a home game. 

Buffalo is coming off a disappointing loss to the Jets on the road, but they should be able to bounce back here easily. The Buffalo offense is the finest in the NFL as they are pacing the NFL in total yards averaging more than 416 yards per game and 27.5 points per game.

The Vikings’ defense put up an impressive effort against the Commanders, holding them to 263 yards, but as a whole, they still rank near the bottom of the league in total yards allowed (368.1).

The Bills continue to impress on defense, collecting 15 takeaways on the year, and the unit is conceding just nine points per game at home.

San Francisco 49ers vs Los Angeles Chargers (+4.5)

With all due respect to Jimmy Garoppolo, the Chargers have the superior quarterbacking talent in Justin Herbert. But that will not matter as the 49ers got an extra week to get healthy, and they have dominated LA teams sweeping the Rams already this season.

The 49ers are simply more talented on both sides of the ball, and the addition of Christian McCaffrey should make it a long day for the Chargers’ defense, that is allowing the third most points on defense (25.8).

The Chargers have talent on both sides of the ball; there is no denying that. The problem is they are dealing with a slew of injuries, and they continue to prove their inability to stop the run.

Los Angeles has also not played well at home as of late, with two losses in their last three games inside SoFi Stadium. While they appear to be getting better, the 49ers a primed to take them down.

Indianapolis Colts (+6.5) vs. Las Vegas Raiders 

Indianapolis also makes the list this week simply because nothing seems to be going their way. Not only did they fire their Head Coach, who has been given five straight different opening day starting quarterbacks in the last five years, but they hired a new head coach in Jeff Saturday, who has zero coaching experience.

To make matters worse, Sam Ehlinger managed to throw for just 103 yards and was sacked nine times, while the offense managed 121 total yards in an embarrassing 26-3 loss to the Patriots last week.

The Raiders are by no means a solid football team after blowing their third double-digit lead of the season last week; however, they have played well at home (2-1) and have posted solid offensive numbers.

One thing Las Vegas does well is play competitive football, and their team has a good chance to get back in the win column against a Colts‘ squad that has lost three straight contests and has just one win on the road this year.


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