2022 NCAA Football ATS Betting Picks for Week 1 of the Upcoming Season

2022 NCAA Football ATS Betting Picks for Week 1 of the Upcoming Season

In just a few short days, we’ll see the start of the 2022 college football season! Week 1 has a great slate of games. Let’s take a look at some of the top games in Week 1, and we’ll give you our NCAA Football Betting picks against the spread.

College Football Week 1 Against the Spread Betting Selections to Wager On

West Virginia Mountaineers @ Pittsburgh Panthers (-7)

The “Backyard Brawl” will take place in Pittsburgh this season. These two programs despise each other, and this rivalry game hasn’t been played since 2011, so there will be a lot of emotions in this one.

Pitt is coming off of a great 2021, but they’ll have a lot of pieces to replace, including Kenny Pickett. West Virginia has struggled the past three seasons, but with transfer JT Daniels under center, the Mountaineers should be improved.

We think Pittsburgh is the better team in this one, and we’re taking them to cover.

Cincinnati Bearcats @ Arkansas Razorbacks (-7)

Sam Pittman has done a phenomenal job of rebuilding the Arkansas program. He has turned them into one of the upper-echelon teams in the SEC. The Razorbacks will have their work cut out for them as they host the Cincinnati Bearcats in their season opener. 

Arkansas should be one of the best teams in the SEC. The Razorbacks are projected to finish right behind Alabama in the SEC West. Quarterback KJ Jefferson returns to run the offense. 

As for the Cincinnati Bearcats, we know that they are coming off of a final four appearance. Luke Fickell has built the Bearcats into one of if not the top team not in a Power 5 conference. The Bearcats lost some key pieces from last year’s team, but they still should have a very strong squad.

We like the SEC school in this one. Give us the Hogs!

Oregon Ducks @ Georgia Bulldogs (-17) (Atlanta) 

Dan Lanning’s head coaching debut will be at his former school, as the defending national champions host the Oregon Ducks. Georgia lost a lot of key pieces from last year’s championship squad, but they will have a ton of talent to replace those players. 

We think the Ducks will hang around early, but Georgia’s talent will overwhelm them late.

Give us the Bulldogs. 

Utah Utes @ Florida Gators (+2.5)

Expectations are very high for a Utah squad that has a great shot at winning the Pac-12. However, the Pac-12 isn’t a dominant conference, and we really aren’t sure how good Utah is.

The Florida Gators program has been a mess the last few seasons. Dan Mullen was let go, and Billy Napier stepped in to try and get the Gators back on track. Florida will have a talented roster, but will they be good enough to beat Utah? This will be at “The Swamp,” and with a raucous home crowd, things could get tough for the Utes. 

Utah has the better team, and they’ll be ready for everything Florida throws at them. Utah is the more experienced squad and will win by a touchdown.

Notre Dame Fighting Irish @ Ohio State Buckeyes

The Ohio State Buckeyes are expected to be a playoff team this season. Ryan Day’s squad should have one of the top offenses in the country, led by Heisman candidate CJ Stroud. 

In Week 1, we’ll have a great scene in Columbus as the Fighting Irish of Notre Dame come to town. Marcus Freeman will be making his head coaching debut in this one, and the defensive guru will have a plan to slow down OSU’s powerful offense. 

Things didn’t start off well for Ohio State last season, as Oregon came into Columbus and upset the favored Buckeyes. We think Ohio State will be ready this season. We predict they beat Notre Dame and cover in the process.

Penn State Nittany Lions (-3) @ Purdue Boilermakers

James Franklin’s squad starts off with a conference game on the road. They’ll be one of the top teams in the Big 10, but unlike in the past, a trip to Purdue isn’t easy. Jeff Brohm has turned the Purdue football program around, and they’ve been successful the past two seasons. 

This one will be tight, but we like Penn State to escape with the cover.

Clemson Tigers (-21) @ Georgia Tech Yellow Jackets

Clemson starts the season off in a conference battle with Georgia Tech. Last season, Clemson only beat Tech by a score of 14-8, signifying Clemson’s struggles last season. After a poor 2021 season, Clemson quarterback DJ Uiagalelei is looking to prove to his critics that he is a pro-prospect and that he can lead Clemson to an ACC championship.

Even though this will be a prime-time matchup in Atlanta, we just can’t see the Yellow Jackets hanging with Clemson. Georgia Tech is on the rise, but they’re not near the standards of Clemson as of yet. 

They’ll be a formidable opponent, but they won’t be on Clemson’s level. The Tigers are out to prove that last year was a fluke, and they’re truly the class of the ACC. 

Clemson wins big!

Florida State Seminoles @ LSU Tigers (-3)

Brian Kelly will be making his debut at LSU. The Tigers struggled last season, but we’ll see if Kelly has righted the ship quickly. 

Florida State hasn’t exactly been setting the world on fire. This one will be sloppy, but the home field advantage in “Death Valley” will help lead the Tigers to a six-point victory. 

Bet NCAA Football to Win
MyBookie Betting Lines for the Game


I have read enough, I need to place my bet now. What to do?

Bet College Football Today
MyBookie Odds for the Games


NCAA Football Betting Center

Updated College Football Betting Odds | Online Sports Betting