2022 NCAA Football Betting Picks: Top Ten Best Games for Week 4 of the Season

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In NCAAF College Football Week 4, one of the most important Big Ten matchups of the season happens when the Ohio State Buckeyes host the Wisconsin Badgers. Buckeyes versus Badgers leads our rankings of the top ten college football games in week 4. Check it out so you can plan your bets against the College Football Odds!

NCAA Football Early Rankings of the 10 Best Games in Week 4 of the 2022 Season

2022 College Football Week 4

• When: Thursday, Sep. 22 – Saturday, Sep. 24

1. Wisconsin Badgers at Ohio State Buckeyes

Ohio State’s offense should be unstoppable, but if there is a defense the Buckeyes play that could contain C.J. Stroud and his bevy of NFL talented receivers, it’s Wisconsin’s. 5 seniors, a graduate transfer, 3 juniors, and a couple of sophomores on D. Badgers at Buckeyes should be epic. 

2. Arkansas Razorbacks at Texas A&M Aggies

Texas A&M has a ton of talent. But the Aggies are young. There’s no telling if all the young talent will have gelled by week 4. Razorbacks quarterback K.J. Jefferson is the real deal. If the Hogs’ defense steps it up, an SU upset can happen. Backing Arkansas against the spread will likely be the top play. 

3. Utah Utes at Arizona State Sun Devils

Kyle Wittingham’s team isn’t shying away from their top Pac-12 opponents. Save for a home game versus USC, Wittingham’s squad plays their toughest conference opponents on the road. Arizona State should field a decent team. But the Devils won’t keep up with Utes QB Cam Rising and Utah’s offense. Utes should win and cover. 

4. Florida Gators at Tennessee Volunteers

Heading into week 1, neither the Gators nor the Volunteers rank in the top 25. By week 4, both SEC teams could be ranked in the top 15.

The Vols have the home field edge, but Florida projects as one of this season’s surprise squads. Wait until the week of before making your pick. Gators versus Vols should be that close. 

5. Clemson Tigers at Wake Forest Demon Deacons

Wake Forest quarterback and Heisman Trophy contender Sam Hartman had a medical procedure in early August that sent him indefinitely to the bench. When this game happens, though, Hartman could be back on the field.

Even if Hartman isn’t, Wake Forest has a shot for the straight up victory. Clemson’s defense should be great. The offense is another matter. 

6. Minnesota Golden Gophers at Michigan State Spartans

Michigan State’s defense allowed 455.9 yards per game last season. The offense played well enough for MSU to go 10-2, but without Kenneth Walker III carrying the load, Sparty could have issues versus a strong Minnesota Golden Gophers team. The Gophers’ moneyline projects as the top play. 

7. West Virginia Mountaineers at Virginia Tech Hokies

Neither fan bases expect much this season, which is why West Virginia Versus Virginia Tech on September 22, a Thursday, isn’t higher in these rankings. Of the two teams, VA Tech should have the slightly better offense.

But West Virginia’s defense could be the best in the Big 12. Hokies versus Mountaineers should be an ultra-competitive match.

8. Baylor Bears at Iowa State Cyclones

Iowa State will be a different team without Breece Hall and Brock Purdy. With that being written, Baylor lost 62% of their offensive production from last season. Ah, but before writing off the Bears to repeat as Big 12 champs or to win this game, consider that top rusher Abram Smith from last season converted from linebacker. The Bears should handle the Cyclones.  

9. Notre Dame Fighting Irish at North Carolina Tar Heels

A couple of seasons ago, this matchup would have made the top five. But in 2022, Notre Dame is the much better team. The Irish will field one of the nation’s best defenses while the offense could turn into a top unit. North Carolina should struggle to move the football without Sam Howell under center.

10. Northern Illinois Huskies at Kentucky Wildcats

Kentucky is a solid team. But in 2021, Northern Illinois went 9-5 overall and started mostly freshman on defense. The Huskies’ are more experienced and should be better this season. Beating the Wildcats in Kentucky is asking a lot. But a Northern Illinois cover victory isn’t out of the question. 

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