If you think that the most valuable phase is postseason maybe you can reconsider it, because you need to know and understand Regular Season MLB to take advantage with the 162 games of each team from April to September.
There are 2 important and very known facts that you can find in the internet and need to know to make the MLB Predictions: Standings and Power Rankings; but here in MyBookie, we’ll going to help you with other key aspects that you could consider if you’re a beginner o you just need some refresing ideas to help you with your betting plans.
Understand Regular Season MLB: Favorites to Win it All
Stay up to date With MyBookie MLB Props, Game Props, Regular Season Wins and Series.
MLB Pitcher and Hitter Rankings
A good way to understand Regular Season MLB is considering the Top 10 outstanding pitchers and hitters of the season 2025. They are pushing formard to win the Cy Young and Edgar Martinez Outstanding Designated Hitter Award, and maybe the MVP.
Last updated: July 14th.
Best Pitchers according to MLB
- 1. Tarik Skubal, Tigers Odds AL MVP Regular Season +8500
- 2. Paul Skenes, Pirates Odds NL MVP Regular Season +16000
- 3. Zack Wheeler, Phillies Odds NL MVP Regular Season +11000
- 4. Hunter Brown, Astros
- 5. Max Fried, Yankees
- 6. Framber Valdez, Astros
- 7. Chris Sale, Braves
- 8. Garrett Crochet, Red Sox
- 9. Logan Webb, Giants
- 10. Jacob deGrom, Rangers
Top Hitters list from MLB
- 1. Cal Raleigh, Mariners Odds AL MVP Regular Season +360
- 2. Aaron Judge, Yankees Odds AL MVP Regular Season -649
- 3. Shohei Ohtani, Dodgers Odds NL MVP Regular Season -952
- 4. Juan Soto, Mets Odds NL MVP Regular Season +1950
- 5. Ketel Marte, D-Backs Odds NL MVP Regular Season +6200
- 6. Byron Buxton, Twins
- 7. Riley Greene, Tigers Odds AL MVP Regular Season +11000
- 8. Ronal Acuña JR, Braves Odds NL MVP Regular Season +7500
- 9. James Wood, Nationals Odds NL MVP Regular Season +6000
- 10. Elly De La Cruz, Reds Odds NL MVP Regular Season +8000
Standings to include in your MLB Predictions
The positions of the teams in the standings is like an x-ray of each team’s performance during the regular season.
In general, many fans view it daily to make future plans for their bets, for example, the Tigers +246 are favorites in the American League, and the Dodgers +118 the National League.
Which teams are Favorites to win the World Series this 2025? Dodgers +222, Tigers +690, Yankees +760, Phillies +810, Astros +1000.
Here are the top team’s standings and odds to win each Division.
Last updated: July 14th.
- Yankees -126 to win MLB AL East Winner Prediction
- Tigers -7692 to win MLB AL Central Winner Prediction
- Astros -429 to win MLB AL West Winner Prediction
- Phillies -155 to win MLB NL East Winner Prediction
- Cubs -295 to win MLB NL Central Winner Prediction
- Dodgers -2000 to win MLB NL West Winner Prediction
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MLB First 5 Innings Odds: How to Bet, Run Line Strategy and Value

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MLB Sports Betting Guide to Understand Regular Season
Learn with MyBookie how to bet baseball through the season with us: Strategies, totals system, handicap games and everything you need to know to understand Regular Season MLB.
- MLB Interleague Betting Strategy
- Early Season MLB Betting Mistakes
- Handicapping Guide For MLB Win Totals
- How to Handicap the MLB Wildcard Round
- Play-In Game Strategy Skip The Starter
- Optimal Strategies To Bet On The MLB Postseason
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- Profitable Underdog Betting Systems for Baseball
- Getting To Know The MLB Betting Totals System
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- Take Advantage of Early MLB Betting Season Uncertainty
- Understanding the Pro Baseball Favorites Betting System
- Do’s and Dont’s of Betting the MLB Over/Under
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- Worst Pitchers Betting System
What are the rule changes for MLB in 2025?
Following the previous years, 2023 and 2024 season, teams play as follows in the Regular Season, adding a couple of changes that you must consider in the MLB predictions.
- Thirteen matches against each of the other four teams in its own division (52 matches in total).
- Six or seven games against each of the other ten teams in their own league (64 games in total).
- Four matches against a “geographic rival” from the other league.
- Three games against each of the other fourteen teams in the other league, for a total of 46 interleague games.
Three straight games with Jose Ramirez HRs
— MyBookie – Bet With The Best (@MyBookie) July 10, 2025
Anyone betting on a 4th?!pic.twitter.com/JuNNBi5wWr
Additionally, let’s see how the playoffs work, because they’re the second most important part of the competition, that had its last modification in 2022, expanding the group of teams in the Wild Card Round.
Moreover, the event is held in bracket format, with 12 teams, six from each league and including the three league division winners and three Wild Card teams per league.
Understand Regular Season MLB: How it Works
- 1st seed: Best league record
- 2nd seed: Winner of the second best division
- 3rd seed: Winner of the third best division
- 4th seed: Best record among Wild Card teams
- 5th seed: Second best record among Wild Card teams
- 6th seed: Third best record among Wild Card teams
For this reason, the first and second place teams will advance directly to the Divisional Series. For the Wild Card Series, the #3 seed will face the #6 seed, and the #4 seed will face the #5 seed.
Wild Card Series
First, the winners of each Wild Card Series advance to the Divisional Series and the losers are eliminated from the postseason.
Second, each game is played at the home stadium of the higher ranked team, in this case #3 and #4 serve as hosts.
MLB’s rule changes to Consider this Season
What should you know about the organization’s regulations? As we have already seen, Major League Baseball has been evolving in different aspects, the rules of the game being one of them. Let’s see them to understand Regular Season MLB.
Runner’s Lane Widening
The runner’s lane has been widened to include the land between the foul line and the turf of the infield. The lane is marked with chalk to prevent runners from straying into foul territory.
Pitch Timer Reduction
The pitch timer has been reduced from 20 seconds to 18 seconds with runners on base. It will remain 15 seconds with the bases empty, and pitchers retain the ability to step off the plate and reset the clock twice per plate appearance without penalty.
Base Blocking Guideline
This is a guideline to the existing rule, and grants the runner the base when it is determined that the fielder has impeded the runner’s progress while not in possession of the ball and was not in the act of fielding the ball.
Pace Adjustments
There are a few other changes intended to tighten things up:
- 1. Pitching Changes: The clock will be reset to 2 minutes, instead of 2:15 if a new pitcher enters the warning zone with less than 2 minutes left on the inning break clock.
- Mound visits: Reduced from five to four visits, with one additional visit to the mound in the ninth inning if the defensive team has no visits left at the end of the eighth inning.
- 3. Avoidance: The Field Timing Coordinator will now reset the clock after a dead ball when the pitcher has the ball and play is ready to resume.
- 4. Batter faced requirement: A pitcher sent to warm up for an inning must face at least one batter.
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