2022 NCAA Football Betting Picks: Top Ten Best Games for Week 2 of the Season

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NCAA College Football Week 2 kicks things off on Friday, September 9 and runs through Saturday, September 10. Great matchups happen in NCAAF Week 2, including former Alabama offensive coordinator and current Texas HC Steve Sarkisian hosting ex-boss Nick Saban and the Crimson Tide in Austin. See below for the top ten contests happening in NCAA Football Week 2 so you can plan your bets against the College Football Betting Lines. 

NCAAF Early Rankings of the 10 Best Games in Week 2 of the 2022 Season

2022 NCAA College Football Week 2

• When: Friday, Sep. 9 – Saturday, Sep. 10

1. Alabama at Texas

Depending on how Bama performs in Week 1 when they take on Utah State, the Crimson Tide could be anywhere from a -3 ½ to -6 ½ favorite. No way Texas is favored in this.

Sarkisian scored Arch Manning for the 2023 season. Arch won’t help him put up points against Will Anderson and the Tide D in this game. Alabama pulls away late in an entertaining affair.  

2. Kentucky at Florida

Kentucky has turned into a solid SEC program. Put Kentucky in the Pac-12 and they’d challenge for a championship spot every season. 

But being solid in the SEC is far from being a title contender. Florida will rebound quickly because Billy Napier has recruited great. Gators prevail in a close game. 

3. Baylor at BYU

BYU is loaded with upperclassmen talent, but we shouldn’t look past how well Baylor QB Blake Shapen played in 2021. The Bears’ signal-caller should have a fantastic season for the defending Big 12 champs.

This happens at Brigham Young. So it won’t be an easy game, but Bears win.

4. USC at Stanford

If this were the early 2000s, Trojans versus Cardinal would top this list. Unfortunately, Stanford isn’t on USC’s level anymore.

Still, if there is any program that can upset Lincoln Riley and USC, it’s David Shaw and Stanford. Riley, Caleb Williams, and the rest of the Trojans escape NoCal with a win.  

5. Iowa State at Iowa

Here’s another matchup that would have been at the top of the list. Iowa State, though, isn’t what it was last season. Breece Hall no longer puts on the cleats for the Cyclones. 

But Iowa lost some good players as well. The corn state’s inter-state rivalry matchup will be interesting and fun. It just won’t have national ranking implications like it has the past few seasons.  

6. Houston at Texas Tech

The game happens in Lubbock, which is why the Texas Tech Red Raiders will have a chance. On paper, though, Houston rolls. 

Dana Holgorsen’s squad lost few key players from last season’s second-place AAC squad. This is a good rivalry that will push both teams. But the Cougars can make a statement. So we should expect Holgorsen’s squad to get it done.  

7. Tennessee at Pittsburgh

Was Pittsburgh’s ACC Championship in 2021 a harbinger of things to come or an anomaly? We’ll find out in NCAAF Week 2. Losing your star quarterback to the NFL is one thing. But having your Biletnikoff award winning wide receiver turn his back on you is almost unforgivable.

Jordan Addison transferred to USC a season after winning the award for the nation’s top wide receiver. Without Addison, Kedon Slovis, who ironically was a Trojan last season, doesn’t have a top target. At least, he doesn’t have one on Addison’s level.

Tennessee coach Josh Heupel took a 3-7 program in 2020 to 7-6 last season. The Vols should be a very good football team. Tennessee rocks and rolls their way to a huge road win and cover.  

8. Boston College at Virginia Tech

VA Tech new head coach Brent Pry should have success. He coached under Frank Beamer in the 1990’s and was fantastic coaching the Penn State Nittany Lions’ defense the past few seasons.

But Pry won’t have much success in this game. Boston College is loaded with upper class talent and the Eagles will field a strong defense. BC gets a road conference win.  

9. Arizona State at Oklahoma State

New ASU quarterback Emory Jones heads to Tempe after playing at Florida. Jones should have a much easier time versus Pac-12 defenses than he did against SEC defenses.

But Jones will struggle in this game. Oklahoma State’s defense was fantastic last season. The fall off won’t be significant. On offense, quarterback Spencer Sanders could be one of the best in the Big 12. Oklahoma State rolls. 

10. Mississippi State at Arizona

Mississippi State head coach returns to the Pac-12 to take on the Arizona Wildcats. When the Bulldogs set their schedule, they probably thought U-of-A would be an easy win.

The Wildcats will put up a fight in this. Linebacker Hunter Echols transfers from USC, quarterback Jayden de Laura started for Washington State last season, and junior transfer wide receiver Jacob Cowing played great at UTEP in 2021.

Arizona landed the twenty-third best recruiting class in the nation. The Wildcats will challenge Leach’s squad. Mississippi State shouldn’t lose, but this won’t be a blowout Bulldogs’ victory.  

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