Buoyed by their first win of the season that came in Week 3, the New York Giants are sure to travel to the Ralph Wilson Stadium in search of nothing less than another win against the Buffalo Bills this Sunday. That is however easier said than done, as they’ll be facing a Buffalo team that is coming off an equally morale-boosting Week 3 victory over division rivals, the Miami Dolphins, and is hoping to stay a little longer on the winning column. This sets up an exciting NFL lines clash that is likely to go down to the wire in the fourth quarter. When it’s all said and done, who will be emerging on the victorious end? Let’s find out, as we take a look at the game preview and analysis specially prepared for you below.
Giants @ Bills Week 4 NFL Game Information and Opening Lines
Venue: Ralph Wilson Stadium, Orchard Park, N.Y.
Date: Sunday, October 4, 2015
Time: 1:00 PM ET
TV: FOX
NFL Lines: Giants (+5.5) at Bills (-5.5), OVER/UNDER 46.5
#Giants vs. Bills in 48 HOURS! Let’s get this W! / info → http://t.co/cC83wdSt4v pic.twitter.com/CsLBJCQgDt
— New York Giants (@Giants) October 2, 2015
New York Giants at Buffalo Bills Football Betting Analysis

Beating the Redskins 32-21 was a largely commendable performance from the Giants, who’d twice shot themselves in the fourth quarter against the Falcons and Cowboys and lost games that they’d have easily won. QB Eli Manning was the star of last Thursday’s show, as he connected with Reuben Randle and Odell Beckham Jr. on two TD passes, while he finished the game with 279 yards on 23 of 32 passing. Outside the touchdown receptions, Randle and Beckham were efficient in moving the ball, finishing with 116 and 79 yards, respectively.
Unfortunately, Manning and his receivers will be facing a terrific Buffalo defense that surrendered just 14 points against Ryan Tannehill and his talented Buffalo offense. After star QBs Tom Brady and Andrew Luck also struggled to breach this defense in Week 1 and 2, there’s no doubt that Manning and his shaky O-line will be in for a tougher night than last week’s game against Washington. RBs Andre Williams and Rashad Jennings have also not been in their effective self, something that invites more trouble to New York’s offense from Buffalo’s stellar front four.




Key Betting Trends
• New York G is 4-6 SU and 5-5 ATS in its last 10 road games
• Buffalo is 6-4 SU and 5-5 ATS in its last 10 home games
• New York G is 5-1-1 ATS in its past 7 games against the Bills
• Buffalo is 4-1 ATS in its last 5 games at home
• New York G is 5-2 ATS in its last 7 games
• Buffalo is 7-2 ATS in its last 9 games
• NY Giants is 4-10 SU in its last 14 games
• Buffalo is 4-2 SU in its last 6 games
• The OVER is 2-1 for both teams this season
• The total has gone OVER in 4 of NY Giants’ last 5 games
• The total has gone UNDER in 14 of Buffalo’s last 19 games
• The total has gone OVER in 5 of NY Giants’ last 6 games on the road
Giants at Bills NFL Picks
Even with Manning and the Giants playing spiritedly, this game has Buffalo’s name written all over it on the win column, and rightfully so. The Bills have a simply-too-good defense that is highly likely to frustrate the Giants, hence giving the Bills enough time to carve apart New York for a win plus cover. In the game total, both teams have sufficient offensive talent to push the game for around 50-or-more points, which should allow the total to go OVER the set 46.5 total.
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