NCAA Football Game Lines: Top 5 Games in Week 4

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The first three weeks of the college football season have been, to put things mildly, more than a little wild. It’s getting to the point where you have to wonder if any of the preseason National Championship favorites are going to make it all the way to the end totally unscathed. The Tennessee Volunteers were the latest to fall, going down to Florida in a game that they started as a heavy favorite. This weekend could prove to be wilder still, as there are some really big matchups coming our way. Who will live to fight another day and who will fall by the wayside and into a hole that is going to be tough to dig out of? Let’s take a look at 5 must bet games coming this weekend to consider in your NCAAF betting.

College Football: Top 5 Games you must Bet on in Week 4 | MyBookie Regular Season Football Betting Preview

Regular Season: August 26 to December 9
Week 4: Thursday, September 21 to Saturday, September 23, 2023

#4 Florida State Seminoles at Clemson Tigers

College Football Odds: Florida State -125 vs Clemson +103
When: Saturday, September 23 at 12:00 PM EST
Where: Memorial Stadium (Clemson, SC), Clemson, SC
TV: ABC

The Seminoles avoided a major scare this past weekend, getting past Boston College in a game that was a whole lot closer than anyone expected. This weekend is a much tougher proposition, as they head to Clemson to face a Tigers team that has bounced back after an opening week loss to Duke. There is an awful lot of football to come, but a win here for the Seminoles would put them in prime position to head to the ACC Championship Game, while making it impossible for Clemson to even consider the playoffs.

Bet Florida State Seminoles vs Clemson Tigers to Win
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#19 Colorado Buffaloes at #10 Oregon Ducks

College Football Odds: Colorado +750 vs Oregon -1200
When: Saturday, September 23 at 3:30 PM EST
Where: Autzen Stadium, Eugene, OR
TV: ABC

After just 1 win last season, the only way for the Buffaloes to go was up, but they are moving up in some serious style. They hit the road to face the Oregon Ducks for what is arguably their biggest game of the season to this point. The Ducks offense is on a roll to start the season, as they too come into this one with a 3-0 record. This will serve as a good measuring stick for Coach Prime to gauge where his team really is in the big picture.

Bet Colorado Buffaloes vs Oregon Ducks to Win
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#15 Ole Miss Rebels at #13 Alabama Crimson Tide

College Football Odds: Ole Miss +220 vs Alabama -280
When: Saturday, September 23 at 3:30 PM EST
Where: Bryant-Denny Stadium, Tuscaloosa, AL
TV: CBS

This is essentially a do or die game for the Crimson Tide, who could potentially see their slim playoff chances come to an end this weekend. Alabama have not looked good this season and are coming off a very poor showing against USF this past weekend. Yes, they got the win, but they will not see the same outcome if they play that way against the Rebels this weekend. If the Rebels can get the win in this one, the SEC West will be blown wide open early on.

Bet Ole Miss Rebels vs Alabama Crimson Tide to Win
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Ohio State Buckeyes at Notre Dame Fighting Irish

College Football Odds: Ohio St. -185 vs Notre Dame +150
When: Saturday, September 23 at 7:30 PM EST
Where: Notre Dame Stadium, Notre Dame, IN
TV: NBC

By the time this weekend comes to a close, one of these teams will see their perfect record disappear in what is an absolutely huge game. A loss here would not necessarily mean the end of playoff dreams for either team, but it would make the remainder of their season that much more difficult. This is going to be a tough road trip for the Buckeyes, but it’s the kind of game that will go a long way with the Playoff Committee if they can come away with the win.

Bet Ohio State Buckeyes vs Notre Dame Fighting Irish to Win
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#24 Iowa Hawkeyes at #7 Penn State Nittany Lions

College Football Odds: Iowa +550 vs Penn State -847
When: Saturday, September 23 at 7:30 PM EST
Where: Beaver Stadium, University Park, PA
TV: CBS

A massive Big Ten matchup between a pair of ranked teams heading into Week 4 with unbeaten records. This will be the first conference game for both teams, who will be looking to keep pace with those that have already played and won in the Big Ten this season. You have to like Penn State playing in their own building, but when it comes to big matchups like this, you can never really be sure how it might go.

Bet Iowa Hawkeyes vs Penn State Nittany Lions to Win
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