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The season is settling into rhythm and College Football Week 5is loaded with betting angles.

This week, our MyBookie writers dive deep into the matchups and bring you their sharpest insights.

From pace-of-play breakdowns to efficiency metrics and situational spots, the Writers’ Roundtable delivers picks rooted in data and market value—not just gut calls.

Expect to find best bets, live dog alerts, and totals recommendations that reflect the trends through the first month of action.

Note: College football odds move quickly, especially once public money hits closer to kickoff.

Always shop the line, know your key numbers, and if a spread or total has shifted, look to alternate markets where the same edge might still apply.

MyBookie Writers’ College Football Week 5 Picks You Can’t Miss

From upset alerts to value totals, our writers bring the kind of sharp insights you won’t find on the surface.

This is where real betting edges live.

No recycled narratives, no cookie-cutter predictions.

Every pick comes from grinding the data—pace splits, efficiency ratings, injury updates, and how the market is reacting to each matchup.

If you’re serious about winning in Week 5, you’ll want to dive into every one of these College Football bets.

Why Sign In Before Making Your Picks

If you haven’t logged in or activated your MyBookie account yet, Week 5 is the time to do it.

Some of the sharpest plays and exclusive insights are best enjoyed once you’re inside.

Want to level up your College Football Week 5 betting strategy?

College Football Week 5 Expert Picks from D.S. Williamson & Henry Watkins

Here are the top plays straight from our in-house writers. No noise, no filler—just focused, data-driven Week 5 picks built for bettors who want the edge.

D.S. Williamson | MyBookie Sports Writer

Florida State -7.5 at Virginia

Florida State is for real.

The Seminoles followed up a 31-17 win over Alabama by squashing a couple of overmatched FSC type squads after scoring 77 and 66.

FSU should have no trouble taking it to Virginia, which isn’t a bad squad but gave up 35 points to NC State a couple of games ago.

The Seminoles are one of the best teams in the country and easily the challenger to Miami in the ACC.

FSU covers.

USC -6.5 at Illinois

The Trojans come off a fantastic 45-31 victory over Michigan State.

But before laying the money on USC to beat an Illinois squad on the road, it’s important to look at the Illini’s 63-10 loss to Indiana with fresh eyes.

Illinois was due for a backward step and a loss like the one the Illini suffered sets them up for a nice bounce back.

USC’s D is still an issue.

So take the points.

Ohio State -9.5 at Washington

The line looks high, feels high, and seems high, but it isn’t.

Sure, Washington is undefeated at 3-0 but a quick look at the scores and the Huskies should have no shot keeping up with the Buckeyes.

For starters, Ohio State’s defense is elite.

It might be the best D in the country.

Second, Washington allowed Colorado State to score 21 and rival Washington State to drop 24.

Who cares if the Huskies scored 59 against the Cougars? The Cougs don’t even play in a real conference.

Ohio State’s D will lockdown Washington’s offense and the Buckeyes’ O should score TD after TD.

The Ohio State at -9.5 is the play.

Arizona at Iowa State -6.5

The Wildcats are getting zero respect.

Arizona comes off a bye where they got a chance to prepare for the Cyclones, one of the favorites tow in the Big 12.

The week before the bye, the Cats dusted Kansas State 23-17.

Iowa State beat Arkansas State 24-16 in their last.

Zona should be no worse than a +3.5 dog.

So there’s value on the line.

If you feel like taking a risk, the Arizona moneyline is playable.

D.S. Williamson Week 5 Picks

Florida State -7.5 @ Virginia – Bet: FSU covers
Ohio State -9.5 @ Washington Bet: USC -6.5
Arizona @ Iowa State -6.5 Bet Ohio State -9.5
College Football ATS Lines

D.S. Williamson’s College Football Week 5 card in the MyBookie Writers’ Picks blends reliable favorites with bold underdog swings, offering bettors the right mix of security and upside—ideal for stacking parlays or uncovering value on spreads and totals.

Henry Watkins | MyBookie Sports Writer

NCAAF Week 5 SU Picks

It has been a nightmare start to the season for the Notre Dame Fighting Irish, as they head into this matchup against Arkansas at 1-2.

The pressure is very much on, but I think they find their way back to victory at home.

There is a great SEC battle upcoming between LSU and Ole Miss, and while Mississippi is heading into hostile territory, I think they win in a high-scoring affair.

Louisiana faces Marshall as a slight favorite, but I think the win in more convincing fashion that the 1 ½ point spread suggests.

Henry Watkins Week 5 SU Picks

Notre Dame @ Arkansas – SU Pick: Notre Dame
LSU @ Ole Miss SU Pick: Ole Miss
Louisiana @ Marshall SU Pick: Louisiana
College Football SU Lines

NCAAF Week 5 ATS Picks

Utah will be looking to bounce back after losing to Texas Tech last weekend, but a trip to West Virginia is always tough.

I like the Mountaineers to cover and keep it close as a +10 ½ point dog.

Another one that I think is going to be close is the matchup between Indiana and Iowa, in what looks to me like a potential field goal game.

With that in mind, I am taking Iowa at +7 ½.

The Tennessee Volunteers are still licking their wounds after an OT loss to Georgia, but I think they get back to winning ways over unbeaten Mississippi State, covering as a 7 ½ point favorite.

Henry Watkins Week 5 ATS Picks

Utah @ West Virginia – ATS Bet West Virginia at +10.5
Indiana @ Iowa ATS Bet Iowa at +7.5
Tennessee @ Mississippi State ATS Bet Tennessee at -7.5
College Football ATS Lines

NCAAF Week 5 O/U Picks

I am starting off with the matchup between Utah State and Vanderbilt, and I am taking the OVER 59 ½ points in this one.

I think it goes well over that number.

Next up is the game between Georgia Southern and James Madison, where the total is set at 57 ½ points.

I think that is a little bit on the low side, so I am taking the OVER.

It’s not all big scoring for me, though, as I think the game between UL-Monroe and Arkansas State will fall under the 55 ½ point total.

Henry Watkins Week 5 O/U Picks

Utah State @ Vanderbilt – Total Bet OVER 59
Georgia Southern @ James Madison Total Bet OVER 57
UL-Monroe @ Arkansas State Total Bet UNDER 55.5
College Football O/U Lines

In his Week 5 slate, Henry brings a mix of rock-solid chalk and high-upside dogs, crafted to give bettors multiple ways to win. From steady covers to live longshots, his card is built to fuel smart parlays and uncover hidden value across the board.

Final Throughts on Betting College Football Week 5 & Betting Takeaways

By Week 5, we start to separate hype from substance.

Our writers stress three themes: trust teams winning up front, factor tempo into totals, and don’t overreact to one-week swings.

College football volatility is where the edges lie—whether that’s fading inflated favorites or grabbing value on overlooked road teams.

Manage your bankroll, target numbers not logos, and stay ready for in-game adjustments.

Ready to turn insight into profit?

MyBookie Writers’ College Football Week 5 Picks

Our writers cut through the lines and numbers to spotlight the smartest angles on spreads, totals, and moneylines for Week 5.

No hype, no fluff—just sharp analysis aimed at finding edges and giving you the confidence to bet with purpose this Saturday.

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