There are several options to look up the strongest teams and players, but we want to show you a good way to understand Regular Season MLB.
You can take advantage in the Postseason staying up to date with the Division, Conference and World Series odds during the Regular Season from April to September.
Moreover, MyBookie recommend other key aspects that you could consider if you’re a beginner o you just need some refresing ideas to help you with your betting plans.
MLB Pitcher and Hitter Rankings
A good way to understand Regular Season MLB is considering the Top 10 outstanding pitchers and hitters of the season 2025. They are pushing formard daily to win the MVP.
For this reason, we suggest to check out the most recent Rankings according to Major League Baseball, along with some odds. Last updated: September 8th
Best Pitchers according to the Last Ranking
- 1. Tarik Skubal, Tigers Odds AL MVP Regular Season +17000
- 2. Paul Skenes, Pirates
- 3. Garrett Crochet, Red Sox
- 4. Nick Pivetta, Padres
- 5. Hunter Brown, Astros
- 6. Jacob deGrom, Rangers
- 7. Trevor Rogers, Orioles
- 8. Cristopher Sánchez, Phillies
- 9. Bryan Woo, Mariners
- 10. Freddy Peralta, Brewers
Last Rankings List for the Top Hitters
- 1. Shohei Ohtani, Dodgers Odds NL MVP Regular Season -20000
- 2. Kyle Schwarber, Phillies Odds NL MVP Regular Season +1925
- 3. Nick Kurtz, Athletics
- 4. Juan Soto, Mets Odds NL MVP Regular Season +2400
- 5. George Springer, Blue Jays
- 6. Ramón Laureano, Padres
- 7. Aaron Judge, Yankees Odds AL MVP Regular Season -360
- 8. Giancarlo Stanton, Yankees
- 9. Bo Bichette, Blue Jays
- 10. Brice Turang, Brewers
Standings to include in your MLB Predictions
The positions of the teams in the standings is like an x-ray of each team’s performance during the year.
In general, many fans view it daily to make future plans for their bets, for example, the Blue Jays +320 are favorites in the American League, and the Dodgers +202 the National League.
Which teams are Favorites to win the World Series this 2025? Dodgers +390, Phillies +590, Brewers +730, Yankees +780 and Tigers +820.
Here are the top team’s standings and odds to win each Division, a better way to understand the Regular Season.
Last updated: September 5th
- Blue Jays -214 to win MLB AL East Winner Prediction
- Tigers -12500 to win MLB AL Central Winner Prediction
- Astros -230 to win MLB AL West Winner Prediction
- Phillies -10000 to win MLB NL East Winner Prediction
- Brewers -12500 to win MLB NL Central Winner Prediction
- Dodgers -265 to win MLB NL West Winner Prediction
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MLB Sports Betting Guide
Learn with MyBookie how to bet baseball through the season with us: Strategies, totals system, handicap games and everything you need to know to understand Regular Season MLB.

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If the #Postseason started today …
— MLB (@MLB) September 8, 2025
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American League
What are the Rule Changes in 2025?
Following the previous years, 2023 and 2024 season, teams play as follows in the Regular Season, adding a couple of changes that you must consider in the MLB predictions.
- Thirteen matches against each of the other four teams in its own division (52 matches in total).
- Six or seven games against each of the other ten teams in their own league (64 games in total).
- Four matches against a “geographic rival” from the other league.
- Three games against each of the other fourteen teams in the other league, for a total of 46 interleague games.
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Additionally, let’s see how the playoffs work, because they’re the second most important part of the competition, that had its last modification in 2022, expanding the group of teams in the Wild Card Round.
Moreover, the event is held in bracket format, with 12 teams, six from each league and including the three league division winners and three Wild Card teams per league.
Understand Regular Season MLB: How it Works
- 1st seed: Best league record
- 2nd seed: Winner of the second best division
- 3rd seed: Winner of the third best division
- 4th seed: Best record among Wild Card teams
- 5th seed: Second best record among Wild Card teams
- 6th seed: Third best record among Wild Card teams
For this reason, the first and second place teams will advance directly to the Divisional Series. For the Wild Card Series, the #3 seed will face the #6 seed, and the #4 seed will face the #5 seed.
Wild Card Series
First, the winners of each Wild Card Series advance to the Divisional Series and the losers are eliminated from the postseason.
Second, each game is played at the home stadium of the higher ranked team, in this case #3 and #4 serve as hosts.
MLB’s rule changes to Consider this Season
What should you know about the organization’s regulations? As we have already seen, Major League Baseball has been evolving in different aspects, the rules of the game being one of them. Let’s see them to understand Regular Season MLB.
Runner’s Lane Widening
The runner’s lane has been widened to include the land between the foul line and the turf of the infield. The lane is marked with chalk to prevent runners from straying into foul territory.
Pitch Timer Reduction
The pitch timer has been reduced from 20 seconds to 18 seconds with runners on base. It will remain 15 seconds with the bases empty, and pitchers retain the ability to step off the plate and reset the clock twice per plate appearance without penalty.
Base Blocking Guideline
This is a guideline to the existing rule, and grants the runner the base when it is determined that the fielder has impeded the runner’s progress while not in possession of the ball and was not in the act of fielding the ball.
Pace Adjustments
There are a few other changes intended to tighten things up:
- 1. Pitching Changes: The clock will be reset to 2 minutes, instead of 2:15 if a new pitcher enters the warning zone with less than 2 minutes left on the inning break clock.
- Mound visits: Reduced from five to four visits, with one additional visit to the mound in the ninth inning if the defensive team has no visits left at the end of the eighth inning.
- 3. Avoidance: The Field Timing Coordinator will now reset the clock after a dead ball when the pitcher has the ball and play is ready to resume.
- 4. Batter faced requirement: A pitcher sent to warm up for an inning must face at least one batter.
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