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Last updated: September 2026
Our writers’ featured 2026 College Football Week 2 picks include Oklahoma -6, Arizona +7, Alabama -10.5, Ohio State moneyline, Oklahoma moneyline, Mississippi State moneyline, Michigan +6, Arkansas +13, Georgia Tech +13.5, Oklahoma vs. Michigan Over 43.5, Arkansas vs. Utah Over 57.5, and Ohio State vs. Texas Over 48.
D.S. Williamson makes Ohio State moneyline his play of the week, while Henry Watkins also backs the Buckeyes to win outright and adds Oklahoma and Mississippi State to his moneyline card. Henry pairs Oklahoma moneyline with Michigan +6, two positions that can both cash if the Sooners win by five points or fewer.
2026 College Football Week 2 Picks
D.S. Williamson: Oklahoma -6, Arizona +7, Alabama -10.5, and Ohio State moneyline.
Henry Watkins: Ohio State moneyline, Oklahoma moneyline, Mississippi State moneyline, Michigan +6, Arkansas +13, Georgia Tech +13.5, Oklahoma vs. Michigan Over 43.5, Arkansas vs. Utah Over 57.5, and Ohio State vs. Texas Over 48.
Shared moneyline opinions: Ohio State and Oklahoma.
Table of Contents
2026 College Football Week 2 Picks and Predictions
D.S. Williamson and Henry Watkins evaluate the Week 2 schedule through quarterback play, roster experience, defensive strength, matchup quality, expected game scripts, and the available betting lines. Their cards cover moneylines, point spreads, and game totals.
Before reviewing the individual predictions, compare the writers’ recommended numbers with the latest College Football betting odds and lines. A spread, total, or moneyline can move after publication and change the value of the original selection.
College Football Week 2 Picks at a Glance
- Oklahoma at Michigan: Oklahoma -6 — D.S. Williamson
- Arizona at BYU: Arizona +7 — D.S. Williamson
- Alabama at Kentucky: Alabama -10.5 — D.S. Williamson
- Ohio State at Texas: Ohio State moneyline — D.S. Williamson
- Ohio State at Texas: Ohio State moneyline — Henry Watkins
- Oklahoma at Michigan: Oklahoma moneyline — Henry Watkins
- Mississippi State vs. Minnesota: Mississippi State moneyline — Henry Watkins
- Oklahoma at Michigan: Michigan +6 — Henry Watkins
- Arkansas vs. Utah: Arkansas +13 — Henry Watkins
- Tennessee vs. Georgia Tech: Georgia Tech +13.5 — Henry Watkins
- Oklahoma vs. Michigan: Over 43.5 — Henry Watkins
- Arkansas vs. Utah: Over 57.5 — Henry Watkins
- Ohio State vs. Texas: Over 48 — Henry Watkins
Read D.S. Williamson’s picks or jump to Henry Watkins’ picks.
Where the College Football Writers Agree
Ohio State at Texas: Both D.S. Williamson and Henry Watkins back Ohio State on the moneyline.
Oklahoma at Michigan: D.S. takes Oklahoma -6, while Henry selects the Sooners on the moneyline. Henry also takes Michigan +6, which can cash alongside the Oklahoma moneyline if the Sooners win by five points or fewer.
The different bet types matter. A prediction that a team will win outright does not always mean the same team offers value against the point spread.
D.S. Williamson | #MyBookie College Football Analyst
D.S. Williamson’s four featured College Football Week 2 picks are Oklahoma -6, Arizona +7, Alabama -10.5, and Ohio State moneyline.
His card targets two ranked favorites against the spread, an experienced underdog receiving a touchdown, and an outright road winner in one of the week’s biggest games.
D.S. Williamson’s Top College Football Week 2 Picks
- Oklahoma -6 at Michigan
- Arizona +7 at BYU
- Alabama -10.5 at Kentucky
- Ohio State Moneyline at Texas — Play of the Week
Saturday, September 12
College Football Week 2 Pick — Oklahoma at Michigan
Pick: Oklahoma -6
Michigan should play much better in this game than it did against Western Michigan. D.S. Williamson does not expect the Wolverines to deliver two poor performances in a row.
Even with an improved Michigan effort, D.S. believes Oklahoma is simply the better team. He views the Sooners’ defense as NFL-caliber and expects their offense to move the ball both on the ground and through the air.
D.S. Williamson backs Oklahoma to win and cover the six-point spread.
College Football Week 2 Pick — Arizona at BYU
Pick: Arizona +7
BYU opened the season with a 66-7 win over Utah Tech, but D.S. believes the level of competition makes that result difficult to evaluate. Arizona’s 35-7 victory over Northern Arizona came against an FCS opponent D.S. considers more credible.
Fifth-year quarterback Noah Fifita leads an Arizona roster loaded with seniors and juniors on both sides of the ball. That experience gives D.S. confidence that the Wildcats can keep the game close and potentially win outright.
D.S. Williamson takes the seven points with Arizona.
College Football Week 2 Pick — Alabama at Kentucky
Pick: Alabama -10.5
Keelon Russell adds a dangerous rushing dimension to Alabama’s offense. D.S. compares that part of Russell’s game to Jalen Milroe and expects it to pressure Kentucky on the ground, although Russell still has room to improve as a passer after completing 60% of his throws.
D.S. sees the larger mismatch when Alabama’s defense faces Kentucky’s offense. The Wildcats have offensive talent, but Alabama’s defense held East Carolina to two rushing yards and 160 passing yards in Week 1.
D.S. Williamson backs Alabama to cover the 10.5-point spread.
College Football Week 2 Pick — Ohio State at Texas
Pick: Ohio State Moneyline | Play of the Week
D.S. expects Julian Sayin and Jeremiah Smith to create problems for a strong Texas defense. His position is not that the Longhorns are weak defensively, but that Smith is the best player in college football and presents a matchup that no opponent can completely solve.
He also gives Ohio State the defensive advantage and questions whether the Texas offense can consistently move the ball against the Buckeyes. With Ohio State playing with a clear sense of purpose, D.S. prefers the outright price over taking points.
D.S. Williamson makes Ohio State moneyline his College Football Week 2 play of the week.
Henry Watkins | #MyBookie College Football Analyst
Henry Watkins divides his College Football Week 2 card into moneyline, point-spread, and game-total selections.
His nine picks include Ohio State and Oklahoma to win outright, three underdogs against the spread, and Overs in three of the week’s featured matchups.
Henry Watkins’ College Football Week 2 Moneyline Picks
Ohio State at Texas
Pick: Ohio State Moneyline
One of the biggest games on the Week 2 schedule sends Ohio State to Texas. Henry Watkins expects a close battle but gives the Buckeyes the edge.
Henry backs Ohio State to win outright.
Oklahoma at Michigan
Pick: Oklahoma Moneyline
Michigan is a difficult opponent at home, but Henry expects Oklahoma to do enough to leave Ann Arbor with the victory.
Henry backs Oklahoma to win outright.
Mississippi State vs. Minnesota
Pick: Mississippi State Moneyline
Henry prefers the moneyline when the point spread is tight. He applies that approach here and selects Mississippi State to defeat Minnesota.
Henry backs Mississippi State to win outright.
Henry Watkins’ College Football Week 2 Point-Spread Picks
Oklahoma at Michigan
Pick: Michigan +6
Henry expects Oklahoma to win, but he is less confident that the Sooners will win comfortably. Taking six points with Michigan allows this spread selection to cash alongside his Oklahoma moneyline pick if the Sooners win by five points or fewer.
Henry takes Michigan +6.
Arkansas vs. Utah
Pick: Arkansas +13
Henry expects Utah to win but is not convinced the Utes should be laying nearly two touchdowns in this matchup.
Henry takes Arkansas +13.
Tennessee vs. Georgia Tech
Pick: Georgia Tech +13.5
Henry believes Tennessee should win the game, but he considers the spread too large and prefers the underdog at the available number.
Henry takes Georgia Tech +13.5.
Henry Watkins’ College Football Week 2 Point-Total Picks
Oklahoma vs. Michigan
Pick: Over 43.5
Henry returns to Oklahoma-Michigan for his first total. He believes the matchup can reach or exceed 50 combined points, giving him room above the listed number.
Henry backs Over 43.5 total points.
Arkansas vs. Utah
Pick: Over 57.5
Henry expects Arkansas and Utah to produce an offense-driven game with enough scoring to clear a total in the upper 50s.
Henry backs Over 57.5 total points.
Ohio State vs. Texas
Pick: Over 48
Henry believes Ohio State and Texas can be pulled into a shootout, creating a game script that favors the Over.
Henry backs Over 48 total points.
What Are the Critical Betting Factors for Choosing College Football Picks?
The most important factors for choosing College Football picks are the available odds, quarterback play, offensive and defensive line matchups, roster experience and depth, injuries, pace, coaching and scheme, home-field advantage, travel, strength of schedule, market movement, and the expected game script. Predicting the winner is only the first step; bettors must also decide whether the current moneyline, spread, or total offers enough value.
College Football Pick Evaluation Checklist
- Current odds: Compare the writer’s recommended number with the line currently available at the sportsbook.
- Quarterback play: Evaluate experience, accuracy, decision-making, mobility, and performance under pressure.
- Line play: Look for protection, run-blocking, pass-rush, and depth advantages in the trenches.
- Roster experience: Account for returning starters, transfers, young players in expanded roles, and the depth available behind them.
- Matchup quality: Early blowouts against overmatched opponents may reveal less than competitive games against stronger teams.
- Pace and game script: Estimate possession volume, scoring opportunities, and how each team will respond when leading or trailing.
- Injuries and availability: Confirm the latest status of quarterbacks, skill players, offensive linemen, pass rushers, and defensive backs.
- Home field and travel: Consider crowd environment, distance, time zones, altitude, heat, and unusual kickoff times.
- Market movement: Identify why the line moved and whether the current number still supports the original pick.
- Bet type: Decide whether the analysis is best expressed through the moneyline, spread, total, team total, player prop, or live market.
Bettors who need help understanding moneylines, point spreads, totals, implied probability, parlays, or line movement can review the MyBookie Betting Academy before evaluating the writers’ weekly selections.
When comparing predictions, separate the expected winner from the best wager. A favorite can win without covering the point spread, while an underdog can lose the game and still cash a spread ticket. Always evaluate the matchup and the price together.
Compare the Latest College Football Odds
Check the current moneylines, point spreads, totals, and available props for every featured matchup before deciding whether a writer’s original betting number still offers value.
View College Football Betting OddsCommon Mistakes When Following Weekly College Football Picks
- Betting a pick after the line has moved beyond the writer’s recommended number
- Treating a moneyline prediction and a point-spread prediction as the same bet
- Overreacting to a blowout against a much weaker opponent
- Ignoring injuries, suspensions, transfers, and late depth-chart changes
- Comparing raw team statistics without adjusting for opponent quality
- Assuming a large favorite will automatically cover the spread
- Increasing stake size to recover losses from earlier games
Before placing a wager, review the applicable sports betting rules to understand how moneylines, point spreads, totals, parlays, postponed games, overtime, and other College Football markets are graded.
2026 College Football Week 2 Picks FAQs
What are D.S. Williamson’s College Football Week 2 picks?
D.S. Williamson selects Oklahoma -6 at Michigan, Arizona +7 at BYU, Alabama -10.5 at Kentucky, and Ohio State moneyline at Texas.
What is D.S. Williamson’s College Football Week 2 play of the week?
D.S. Williamson makes Ohio State moneyline at Texas his College Football Week 2 play of the week.
What are Henry Watkins’ College Football Week 2 moneyline picks?
Henry Watkins backs Ohio State to beat Texas, Oklahoma to beat Michigan, and Mississippi State to beat Minnesota.
What are Henry Watkins’ College Football Week 2 spread picks?
Henry Watkins selects Michigan +6 against Oklahoma, Arkansas +13 against Utah, and Georgia Tech +13.5 against Tennessee.
What are Henry Watkins’ College Football Week 2 totals picks?
Henry Watkins selects Oklahoma vs. Michigan Over 43.5, Arkansas vs. Utah Over 57.5, and Ohio State vs. Texas Over 48.
Which College Football Week 2 picks do the writers agree on?
Both writers back Ohio State to beat Texas and Oklahoma to beat Michigan. D.S. takes Oklahoma -6, while Henry uses the Oklahoma moneyline and also takes Michigan +6.
Why can a College Football pick change after publication?
Injuries, suspensions, depth-chart news, weather, and betting action can move a moneyline, spread, or total. A pick made at one number may offer less value after the odds change.
Put This Week’s College Football Picks Into Action
Compare the latest prices for every D.S. Williamson and Henry Watkins selection across the Week 2 moneyline, point-spread, and totals markets.
View College Football Betting OddsThe picks in this article reflect each writer’s opinion at the listed betting number and do not guarantee a winning result.
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