Jacksonville vs. Indianapolis Odds and Betting Prediction for NFL Week 1

Jacksonville vs. Indianapolis Odds and Betting Prediction for NFL Week 1

This Sunday, AFC South rivals, the Jacksonville Jaguars and the Indianapolis Colts, are set to face off in one of the Week 1 NFL showdowns.

Both teams demonstrated their prowess during the preseason, with the Jaguars boasting a flawless 3-0 record, joining an elite group of just three unbeaten teams. Meanwhile, the Colts held their own with a respectable 2-1 preseason record.

The Jacksonville Jaguars enter this matchup as reigning AFC South champions, having secured a playoff victory over the Los Angeles Chargers in the previous season.

Their impressive 9-8 record surpassed the Titans’ 7-10 performance, finishing the regular season on a remarkable five-game winning streak. On the flip side, the Indianapolis Colts had a challenging season, concluding with a disappointing 4-12-1 record and a disheartening seven-game losing streak.

The Jacksonville Jaguars come into this game listed at -5, with a total of 45 points. The Jaguars are favorites in this game at -5 in the NFL Odds Week 1.


Jacksonville vs. Indianapolis Odds and Betting Prediction for the Game | MyBookie NFL Week 1 Regular Season Preview

Jacksonville Jaguars vs Indianapolis Colts | NFL Week 1
Spread: Jaguars -5 -110 / Colts +5 -110
Moneyline: Jaguars -187; Colts +234
Total: 45 – Over -110 / Under -110

Sunday, September 10th, 2023 at 1:00 PM | FOX
Lucas Oil Stadium, Indianapolis, IN


Defending AFC South Champion Jacksonville Jaguars

The Jacksonville Jaguars are gearing up for the 2023 season with high hopes of clinching another divisional championship. During the off-season, the Jaguars made significant moves by acquiring two promising first-round picks, Anton Harrison from Oklahoma and Brenton Strange as a tight end. Their impact on the upcoming season remains a topic of keen interest.

Under center Trevor Lawrence is set to lead the Jaguars once again. In the previous season, Lawrence showcased his prowess, amassing over 4,100 passing yards in his NFL Player Stats. Christian Kirk had a standout season, accounting for over 25% of those yards. 

Adding to the excitement, Calvin Ridley returns to the Jaguars after a season-long absence. The ground game is expected to be fortified by former Clemson running back Travis Etienne Jr., who racked up an impressive 1,126 yards and five touchdowns on 220 carries last season. Lawrence aims to be a contender in the NFL MVP Odds as the season unfolds.

The Jaguars kick off their season with a matchup against the Kansas City Chiefs, followed by a game against the Houston Texans in their next two outings.


Colts Rough Start to 2023

The Indianapolis Colts’ off-season has been far from ideal. To sum it up, the ongoing drama involving their star running back’s desire to leave the team has escalated to the point where he will be absent from the lineup for four games.

This situation forces the Colts to field a rookie quarterback, with Deon Jackson as the leading candidate to support him. The rookie quarterback in question is Anthony Richardson, who has been granted the starting role over seasoned players like Gardner Minshew and Sam Ehlinger.

Richardson’s success will hinge on his chemistry with Michael Pittman Jr., who fell just 75 yards short of a 1,000-yard season last year. The Colts struggled significantly in passing last season, recording only 17 passing touchdowns while suffering 20 interceptions.

Predicting the Indianapolis Colts’ performance could be challenging until we see what Richardson brings to the table.

Following this game, the Indianapolis Colts face consecutive away games. They will first take on the Houston Texans in Week 2, followed by a clash with the Baltimore Ravens in Week 3, before returning home to face the Rams and Titans.


Jaguars Start Hot

This game should be all Jaguars. It does not matter where this game is at. If the Jaguars want to be a threat in the AFC this season, this is a game they should win and win easily.

The Jaguars should win by a touchdown or more over the Colts. Many expect Indianapolis to be one of the worst teams in the National Football League in 2023.

NFL Week 1 Afternoon Game | Bet Jaguars vs Colts
MyBookie Betting Lines for the Game


Jacksonville Jaguars Last 5

Date OPP Result
8/26/23 vs MIA W31-18
8/19/23 @ DT W25-7
8/12/23 @ DAL W28-23
1/21/23 @ KC L27-20
1/14/23 vs LAC W31-30

Jacksonville Jaguars Injury Report

Name | Position Status DATE
No injured players    

Indianapolis Colts Last 5

Date OPP Result
8/24/23 @ PHI W27-13
8/19/23 vs CHI W24-17
8/12/23 @ BUF L23-19
1/8/23 vs HOU L32-31
1/1/23 @ NYG L38-10

Indianapolis Colts Injury Report

Name | Position Status DATE
Zavk Moss RB Questionable Sep 4
Shaquille Leonard LB Questionable Sep 4


The following NFL betting odds are based on MyBookie Sportsbook.

Super Bowl Odds to Win this 2025 NFL Season

The following NFL betting lines are based on MyBookie Sportsbook.

Teams Odds
San Francisco 49ers +550
Kansas City Chiefs +700
Baltimore Ravens +800
Buffalo Bills +1000
Detroit Lions +1200
Cincinnati Bengals +1300
Dallas Cowboys +1600
Philadelphia Eagles +1800
Miami Dolphins +2000
Green Bay Packers +2200
Houston Texans +2200
LA Chargers +2500
New York Jets +2500
Jacksonville Jaguars +3500
Los Angeles Rams +3500
Cleveland Browns +4000
Minnesota Vikings +4000
Atlanta Falcons +5000
Chicago Bears +5000
Indianapolis Colts +5000
Denver Broncos +7500
Las Vegas Raiders +7500
New Orleans Saints +7500
Pittsburgh Steelers +7500
Seattle Seahawks +7500
Tampa Bay Buccaneers +7500
Arizona Cardinals +10000
New England Patriots +15000
New York Giants +15000
Tennessee Titans +15000
Washington Commanders +15000
Carolina Panthers +25000

Bet Super Bowl Lines to Win


I have read enough, I need to place my bet now. What to do?

Bet NFL Lines
MyBookie Odds for the Games


NFL Betting Center

Updated NFL Odds | Online Sports Betting