Lions vs 49ers NFC Championship Odds

2024 Lions vs 49ers NFC Championship Odds : Spread and Total Lines for the Game

The NFC Championship is set for Sunday from Levi’s Stadium in Santa Clara California. The San Francisco 49ers are set to take on the Detroit Lions. This is the second game of the day on Sunday, and the winner will move to the Super Bowl at Allegiant Stadium in Las Vegas. The opponent will be either the Kansas City Chiefs or Baltimore Ravens. 

The San Francisco 49ers are favorites in this game. The 49ers are a touchdown favorite over the Lions. The total for this game is listed at 50.5 points. If you like to bet the moneyline, the 49ers are -330 and the Lions are +240.

Let’s take a look at our betting preview as MyBookie offers the NFL lines for this NFC Conference Championship match with the 49ers as favorites at -7 over the Lions and a total set at 51.5. This is just the last step for Super Bowl.


Lions vs 49ers Odds and Betting Pick for this 2024 NFC Conference Championship Matchup | MyBookie NFL Playoff Preview

Detroit Lions at San Francisco 49ers | NFC Conference Championship
ATS Odds: 49ers -7
Money line Odds: San Francisco 49ers Line: -330 / Detroit Lions Line: +240
Over/Under Odds: 51.5

Sunday, January 28th, 2024 at 3:00 pm ET | FOX
Levi’s Stadium, Santa Clara, CA


Teams Coming into the NFC Conference Game

The San Francisco 49ers are at home after garnering the top seed in the NFC. The 49ers won the NFC West, and finished with a 12-5 record. San Francisco fell in Week 18 without their starters playing, and then took the wildcard weekend off. The 49ers then beat the Green Bay Packers last week in the divisional round.

For the Detroit Lions, they ran away with the NFC North title. Their 12-5 record was three games better than Green Bay. The Lions picked up the three side, and barely knocked off the Los Angeles Rams at home in wildcard weekend action. Last week, the Lions remained at home due to a Dallas loss, and they beat the Tampa Bay Buccaneers. This will be the first road playoff game for the Lions this season.


The Lovable Lions

Where to start with the Detroit Lions? Well, Dan Campbell has turned this franchise from a consistent losing one to a team with a ton of young talent on the verge of getting to the Super Bowl. If the Lions do not win this game, they will be one of the favorites to get to the Super Bowl next season.

Jared Goff has put together his best season as a starting quarterback for the Lions. The former Rams signal caller threw for more than 4,500 yards in the regular season. So far through two postseason games, he has 563 yards and three touchdowns. It helps that his talent around him is outstanding as well.

The Lions have a duo in the receiving game and a duo in the rushing game. Amon-Ra St. Brown and Sam LaPorta combined for more than 2400 receiving yards in the regular season, and both finished with 10 touchdowns. Jahmyr Gibbs and David Montgomery went over 2,000 combined rushing touchdowns, and had 23 touchdowns.

Guys like Craig Reynolds and Jameson Williams go under the radar for the Detroit Lions. The Lions also have several key defensive studs, including defensive end Aidan Hutchinson. He led the team with 11.5 sacks on the season. Kerby Joseph protects against the passing game, as he had four interceptions.


Top Seeded 49ers

Kyle Shanahan and the San Francisco 49ers are looking to eliminate the bad  taste in their mouths from the NFC title game loss of a season ago. The 49ers fell to the Eagles in that one. San Francisco during the regular season scored 28.9 points per game, and allowed opponents to score 17.5 per game. The defense was third in the league.

The passing game ranked fourth under Brock Purdy at quarterback. The running attack was third, with 140.5 yards per game. Purdy was not fantastic in the win over the Packers, but got the job done. He finished with 252 yards and a touchdown. During the regular season, Purdy tossed 31 touchdowns to just 11 interceptions.

Christian McCaffrey was the main man in the run game. The former Stanford star rushed for two touchdowns last week. On the season, he had 14 rushing touchdowns and an additional 7 via the passing game. McCaffrey went over 2,000 all purpose yards, and saw the ball in his hands over 330 times.

Deebo Samuel is questionable for this game with a shoulder injury. He helps Purdy with the weapons in the offense. He was third with 892 yards on the season. Him and Brandon Aiyuk both had 7 receiving touchdowns, while George Kittle settled in with 6. Kittle caught a touchdown in the win over Green Bay.


Past NFC Title Game History

This will be the 19th time the San Francisco 49ers have played in the NFC title game. They have lost the last two. The last time they won in the NFC title game was in 2020 over the Green Bay Packers. Overall, the 49ers are 7-11 in NFC Championship games.

The last time the Detroit Lions played in the NFC title game was 1991. In that game, the Washington Commanders scored 41 points and blew the Lions out. Before that, the Lions had FC title game.

These two teams have not played each other since the 2021 season. That was a 41-33 shootout win for the San Francisco 49ers. Overall, the 49ers have won the past two meetings. In franchise history, the 49ers are 39-28-1 against the Lions.


NFC Conference Championship Pick and Prediction | Lions vs 49ers

It has been a fun story for Dan Campbell and the lovable Detroit Lions. There has been a long line of losing in the Detroit Lions history. The Lions are finally in the NFC title game again, and a win away from getting to the Super Bowl for the first time in franchise history. This is one of the biggest sports days in Detroit sports history.

But, the 49ers are another level right now. Deebo Samuel is a big deal, and we feel he is going to play in this game, and make a difference. If he cannot go, this may make a difference. But, the ability of Christian McCaffrey and the 49ers defense is going to be enough in this game. We like the 49ers to win this game. Our final betting pick is the San Francisco 49ers -7. Our final score prediction is the San Francisco 49ers 34-24 over the Detroit Lions. Enjoy the game!

2024 NFC Conference Championship ATS Pick: San Francisco 49ers -7 | Bet 49ers vs Lions
MyBookie Betting Lines for the Game


Detroit Lions Team

12-5 | 6-3 Away

Lions Last 5

Date OPP Result
1/21/24 vs TB W31-23
1/14/24 vs LAR W24-23
1/7/24 vs MIN W30-20
12/30/23 @ DAL L20-19
12/24/23 @ MIN W30-24

Lions Injury Report

Name | Position Status Date
Alex Anzalone LB Questionable Jan 28
Kalif Raymond WR Questionable Jan 28
Brock Wright TE IR May 1
Josh Reynolds WR Questionable Jan 28
Sam LaPorta TE Questionable Jan 28

San Francisco 49ers Team

12-5 | 5-3 Home

49ers Last 5

Date OPP Result
1/20/24 vs GB W24-21
1/7/24 vs LAR L21-20
12/31/23 @ WSH W27-10
12/25/23 vs BAL L33-19
12/17/23 @ ARI W45-29

49ers Injury Report

Name | Position Status Date
Deebo Samuel WR Questionable Jan 28
Kalia Davis DT IR-r Jan 28

San Francisco 49ers vs Detroit Lions Betting Trends

  • The 49ers last covered the spread at home vs. the Cowboys in Week 5; they have been 0-6 ATS at home since, including the playoffs.
  • They have been favored in every game this season and touchdown or better favorites in 11 (9-2 SU and 5-6 ATS).
  • The OVER is 10-8 this season for the 49ers and 5-4 at home; it was 0-1 when the total was 50+ points.
  • In conference games, the OVER has gone 7-6.
  • Kyle Shanahan is 7-3 in postseason play; Brock Purdy is 3-1 as a starter in the playoffs.
  • They were underdogs three times this season (vs. Ravens +3, vs. Chiefs +4, and Cowboys +4.5), all on the road. The Lions went 1-2 SU and 2-1 ATS in those games.
  • In their last six games (including playoffs), the 49ers are 5-1 SU and ATS (they were -3 vs. the Rams in the wild card round but won by one point).
  • The OVER is 12-7 for the Lions this season and 5-4 on the road.
  • In conference games, the OVER has gone 9-5 for the Lions, but 1-2 when Detroit was on the road and an underdog and 0-3 when the total was 50+ points.
  • Jared Goff is 3-6 all-time vs. the 49ers, 0-1 SU, and 1-0 ATS with the Lions.


The following NFL betting lines are based on MyBookie Sportsbook.

Super Bowl Odds to Win this 2025 NFL Season

The following NFL betting lines are based on MyBookie Sportsbook.

Teams Odds
San Francisco 49ers +550
Kansas City Chiefs +700
Baltimore Ravens +800
Buffalo Bills +1000
Detroit Lions+1200
Cincinnati Bengals +1300
Dallas Cowboys +1600
Philadelphia Eagles +1800
Miami Dolphins +2000
Green Bay Packers +2200
Houston Texans +2200
LA Chargers +2500
New York Jets +2500
Jacksonville Jaguars +3500
Los Angeles Rams +3500
Cleveland Browns +4000
Minnesota Vikings +4000
Atlanta Falcons +5000
Chicago Bears +5000
Indianapolis Colts +5000
Denver Broncos +7500
Las Vegas Raiders +7500
New Orleans Saints +7500
Pittsburgh Steelers +7500
Seattle Seahawks +7500
Tampa Bay Buccaneers +7500
Arizona Cardinals +10000
New England Patriots +15000
New York Giants +15000
Tennessee Titans +15000
Washington Commanders +15000
Carolina Panthers +25000

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Lions vs 49ers 2018 NFL Week 2 Lines & Expert Pick

Previous Betting News

It’s never ideal to open the new NFL season with a loss, but it goes without saying that going 0-2 is a whole lot worse. With just 16 games in the regular season, getting into an early hole dramatically decreases the chances of a team making it to the playoffs. You also have to consider that a pair of losses to start the season does little for the confidence, while also heaping on the pressure that some teams are just not equipped to handle. The Detroit Lions and San Francisco 49ers both fell to defeat in NFL Week 1 of the season and are now desperate for a win that might help right the ship.

The loss that the 49ers took in the opening week was not totally unexpected, but the same cannot be said for the Lions, as they were pummeled by a Jets team that many people believed would struggle this year. We will have a better idea of where each of these teams is at after this one. The 49ers are in as a 6 point NFL home favorite, with the point total set at 46.


Lions vs 49ers NFL Week 2 Lines & Expert Pick

When: Sunday, September 16 at 4:05 PM EST | FOX
Where: Levi’s Stadium, San Francisco
Radio: SiriusXM


Why bet on the Detroit Lions?

Despite his best efforts, QB Matthew Stafford was just not able to dig out of the hole that his defense dug for him in Week 1. Stafford threw for 300 yards, which is common practice for him, but could only lead his team to 17 points in a disastrous 48-17 loss to the New York Jets. Given that the Lions were essentially forced to start throwing the football all over the field from the start, their rushing numbers look a little bleaker than expected, as they managed just 39 yards on the ground in Week 1.

This is not the match-up they would have hoped for in their second week given that the Lions are just 1-9 against the 49ers in their last 10 meetings. In the last 9 games played in San Francisco, the Lions have gone just 1-6-2 ATS, with 6 of the last 8 going UNDER.


Team Stats

  • Average Score For: 17.00
  • Total Yards: 339.00
  • Rush Yards: 39.00
  • Passing Yards: 300.00
  • Average Score Against: 48.00
  • Total Yards: 349.00
  • Rush Yards: 169.00
  • Passing Yards: 180.00

Why bet on the San Francisco 49ers?

There was a belief that the momentum gained with the 5 straight wins to end last season would carry over into 2018, but the 49ers now know that there is still a lot of work to be done before they get back near the top. They opened the season with a 24-16 loss to a Minnesota Vikings team widely tipped to win the Super Bowl. Moving the ball on the Vikings is never an easy task and that proved to be accurate last week, with the 49ers getting just 329 yards of total offense.

This week should give us a better idea of what they can do on the offensive side of the football since San Francisco has dominated the Lions in recent meets. Besides being 9-1 SU versus the Lions in the last 10, they are also 6-2-2 ATS in those games.


Team Stats

  • Average Score For: 16.00
  • Total Yards: 327.00
  • Rush Yards: 90.00
  • Passing Yards: 237.00
  • Average Score Against: 24.00
  • Total Yards: 343.00
  • Rush Yards: 116.00
  • Passing Yards: 227.00

Latest Lions vs 49ers NFL Week 2 Betting Trends

  • Detroit is 2-3-1 ATS in its last 6 games on the road
  • Detroit is 1-9 SU in its last 10 games when playing San Francisco
  • The total has gone OVER in 7 of Detroit’s last 10 games
  • San Francisco is 4-2 ATS in its last 6 games
  • San Francisco is 5-1 SU in its last 6 games
  • The total has gone OVER in 5 of San Francisco’s last 7 games at home

Expert Pick & Final Score Prediction

The 49ers have had this match-up all to themselves in recent years, so look for them to win and cover here, with the point total falling just UNDER.

Score: Detroit Lions 14 – San Francisco 49ers 27



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