College Football National Championship Picks & Predictions

MyBookie NCAAF Writers’ National Championship Picks & Predictions

The College Football Playoff delivers four elite matchups where quarterback play, defensive efficiency, and late-season form outweigh rankings and brand bias.

With neutral-site pressure, limited preparation windows, and tightly priced NCAAF odds and lines, the CFP creates narrow but exploitable edges for bettors who understand matchup dynamics and postseason game flow.

D.S. Williamson attacks the board through positional mismatches, late-season defensive trends, and quarterback reliability — targeting spreads and moneylines where public perception lags behind on-field reality. Meanwhile, Henry Watkins evaluates SU, ATS, and O/U markets using tempo, efficiency, and playoff-specific scoring profiles.

From identifying when elite defenses finally separate to spotting totals mispriced by regular-season data, these are actionable playoff betting insights designed to help you beat the number — not chase it.

Welcome to the MyBookie Writers’ College Football Playoff Picks & Predictions — where sharp analysis meets postseason opportunity.

 

MyBookie Writers’ College Football Playoff Picks & Predictions

The CFP slate demands precision — and each pick below is built on matchup clarity, quarterback play, and postseason context.

These selections break down college football picks, NCAAF odds and lines, and playoff-specific betting principles used by disciplined bettors.

Whether you’re targeting sides, totals, or situational value, MyBookie offers live NCAAF lines, fast payouts, and the flexibility to react as playoff narratives evolve.

 

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The College Football Playoff is here — and MyBookie experts break down where real value exists.

D.S. Williamson and Henry Watkins deliver SU, ATS, and O/U picks based on quarterback play, defensive strength, and current NCAAF odds and lines.

Start the CFP strong with MyBookie’s expert College Football Playoff Picks & Predictions.

 
 

D.S. Williamson | MyBookie Sports Writer

D.S. Williamson is a matchup-first handicapper focused on quarterback reliability, defensive structure, and pricing inefficiencies.

His playoff approach prioritizes execution under pressure and regression from regular-season narratives.


 

🏈 D.S. Williamson CFP Picks

 

CFP Semifinal Snapshot

Game

Miami Hurricanes vs Ole Miss Rebels

Market Lean

Miami -3.5  |  UNDER 51.5

 

10 Miami Hurricanes -3.5 versus 6 Ole Miss Rebels

Ole Miss versus Miami should be an intriguing matchup. The Rebels may be a team of destiny. After watching how they dominated the Georgia Bulldogs in the second half of their College Football Playoff Quarterfinals matchup, it’s difficult to say otherwise.

Ole Miss headed into halftime down 12 to 21. But in the second half, it was all Rebels in a stunning 39-34 victory. Georgia’s vaunted D couldn’t stop Trinidad Chambliss. The star quarterback will be at his best versus Miami, which gives Ole Miss a shot.

But beating Georgia’s D is different than taking down Miami’s the Hurricanes have stopped two of the best offenses in the nation in their last two games, holding Texas A&M to 3 points in a 10-3 victory and squashing the Ohio State Buckeyes 24-14.

The 10 point win over Ohio State impresses more because Miami’s Carson Beck, the former Georgia QB, got into a rhythm. Beck and the Miami offense should move the ball versus Ole Miss while Chambliss and the Rebels will struggle some. Back the Canes to cover to under 51.5.

Writer’s Pick: Miami -3.5 & UNDER 51.5

Miami vs Ole Miss Betting Lines


CFP Semifinal Snapshot

Game

Oregon Ducks vs Indiana Hoosiers

Market Lean

Indiana -4.5  |  UNDER

 

5 Oregon Ducks versus 1 Indiana Hoosiers -4.5

The way Oregon handled the Big 12 Champion Texas Tech Red Raiders suggests the Ducks have what it takes to stick with Indiana. But we have history to guide us in this matchup.

The Hoosiers beat Oregon in Autzen during the regular season. Indiana doesn’t make mistakes. There is almost never a blown assignment. Not only that but Curt Cignetti is the best in the country at analyzing a situation and adjusting.

So Dan Lanning has to be on his toes in this one. Lanning is good enough to adjust but his players don’t appear to be as disciplined as Indiana’s. The Heisman Trophy winner audibles like an NFL QB and the Hoosiers’ D can shut down any offense. The top seed covers the -4.5 in an under game.

Writer’s Pick: Indiana -4.5

Oregon vs Indiana Betting Lines

 
 

Henry Watkins | MyBookie Sports Writer

Henry Watkins | MyBookie Sports Writer

Henry Watkins evaluates playoff games through tempo, efficiency, and late-game scoring dynamics.

His CFP analysis focuses on how games evolve once pressure peaks.


 

🏈 Henry Watkins CFP Picks

 

NCAAF Bowl Game SU Picks

There are just 3 games remaining in the college football season, with the semi-finals coming up next. The Miami/Ole Miss game is a tough one to predict, as I did not expect either of them to be here. I think the Rebels have a bit of a chip on their shoulder after the Kiffin debacle, so I am on them to win.

The other semi-final looks a little clearer to me. In think that Indiana has Oregon beat in every facet of the game, which makes them the obvious choice to move on.

Henry’s SU Card

Miami vs Ole Miss – SU Pick: Ole Miss

Oregon vs Indiana – SU Pick: Indiana

Bet CFP Moneylines


NCAAF Bowl Game ATS Picks

I have my winners picked out for the semi-finals, but what about the point spread? Miami is the favorite in the first of the two games, but since I like Ole Miss to win, I obviously like them to cover.

I also think that Indiana is going to beat Oregon rather comfortably, which makes the current spread of 4 ½ points look like something of a bargain.

Henry’s ATS Card

Miami vs Ole Miss – ATS Pick: Ole Miss (to cover)

Oregon vs Indiana – ATS Pick: Indiana -4.5

Bet CFP Spreads


NCAAF Bowl Game O/U Picks

From what we have seen out of both Miami and Ole Miss, we have a pair of offenses firing on all cylinders. I think that carries over into the semi-final game, which will give us an offensive duel. With that in mind, let’s take the OVER 51 ½ points.

The other matchup is, in my opinion, a little bit trickier. I have a feeling that Indiana is going to dominate this one, but I am still leaning toward the OVER, which is currently set at 47 points.

Henry’s Totals Card

Miami vs Ole Miss – Pick: OVER 51.5

Oregon vs Indiana – Pick: OVER 47

Bet CFP Totals

 
 

Final Take: Bet the College Football Playoff with Precision

The CFP punishes casual betting and rewards preparation.

With expert insight from D.S. Williamson and Henry Watkins, you’re equipped to attack spreads, totals, and moneylines before the market tightens.

Lock in value early and bet smarter throughout the College Football Playoff at MyBookie Sportsbook.

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Updated Vegas Odds & Spreads at MyBookie
 

About the Author

MyBookie's Expert Writer
  • Henry Watkins
  • Henry Watkins is a Sports Writer at MyBookie. Originally from Scotland and currently residing in Metro Atlanta with his wife Penny, Henry covers a range of topics, including competitive and professional sports as well as sports business. In addition to his sports writing, he is also an author of horror fiction, with works such as Karaoke Night, Crueller, and Off The Grid.
 
 

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