The 2025 College Football season moves into Week 12 — and this slate is packed with playoff implications, sharp lines, and underdog value plays that smart bettors can’t ignore.
With conference titles within reach and bowl positioning at stake, market movement is accelerating — making early line grabs and disciplined bankroll management essential for profitable weekends at MyBookie Sportsbook.
D.S. Williamson breaks down high-profile clashes, coaching momentum, and defensive mismatches to pinpoint where sportsbook lines have over-adjusted, while Henry Watkins builds his Week 12 card with proven SU, ATS, and O/U strategies drawn from data-driven betting models.
From CFP bubble games to SEC dominance plays, these aren’t hunches — they’re predictive insights crafted to help you beat the closing number and maximize value.
Get ready for another round of MyBookie Writers’ College Football Week 12 Picks & Predictions — your blueprint for smarter, sharper, and more profitable betting this Saturday.
MyBookie Writers’ College Football Week 12 Picks & Predictions
From SEC showdowns to Big Ten power plays, College Football Week 12 offers elite matchups with major betting value across every conference.
Featured games include Texas at Georgia, Florida at Ole Miss, South Carolina at Texas A&M, and Iowa at USC — all featuring NCAAF betting odds and market edges worth targeting.
Whether you’re chasing a parlay, hunting totals, or backing underdog covers, MyBookie delivers live college football odds, early lines, and instant payouts that make every wager count.
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College Football Week 12 is here — and our MyBookie experts are breaking down the weekend’s top matchups.
D.S. Williamson and Henry Watkins deliver data-driven SU, ATS, and O/U picks rooted in matchup analysis, team form, and market movement to help you find value before kickoff.
From Texas vs Georgia to Iowa vs USC, every prediction combines insight, confidence, and the best NCAAF odds available at MyBookie.
Bet smarter, play faster, and cash bigger this Saturday — only with MyBookie’s College Football Week 12 expert picks & predictions.
D.S. Williamson | MyBookie Sports Writer
Since 2008, D.S. Williamson has written about sports and sports handicapping.
His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to sportsbook odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
🏈 NCAAF Week 12 Winning Picks
Texas at Georgia -6.5
The Texas Longhorns travel to Georgia hoping to keep their hat in the College Football Playoff ring.
Unfortunately for the Horns, UGA has begun to surge. In their last outing, the Georgia Bulldogs blasted Mississippi State 41–21.
Georgia’s defense isn’t as dominant as it was in past seasons, but it should handle a Texas Longhorns offensive line that still has some issues. The Texas defense, meanwhile, has started to show signs of wear and tear.
UGA covers at home.
Writer’s Week 12 Pick: Georgia -6.5 (Home Cover)
Texas vs Georgia Betting Lines
Florida at Ole Miss -13.5
There are some great matchups in Week 12, and the key is finding overlays — this one is clear.
The Ole Miss Rebels are an overlay versus the floundering Florida Gators. Often when a team fires its coach, the players rally behind the interim HC — not this time. Florida’s roster looks checked out after a 38–7 loss to Kentucky in Week 11.
Mississippi remains in the CFP conversation if they can win out. Lane Kiffin’s squad has both sides of the ball clicking and should roll to a 20+ point win at home.
Writer’s Week 12 Pick: Ole Miss -13.5 (Rebels Rout)
Florida vs Ole Miss Betting Lines
South Carolina at Texas A&M -17.5
At the start of the season, this matchup looked like a potential SEC decider — but their paths have gone in opposite directions.
The Texas A&M Aggies are undefeated and one of the best teams in the country, while the South Carolina Gamecocks are wasting LaNoris Sellers’ final season under center.
Mike Elko’s team has paired an elite defense with a high-powered offense — and Elko’s motivation skills keep the Aggies locked in weekly. Expect another statement victory and cover.
Writer’s Week 12 Pick: Texas A&M -17.5 (Aggies Roll)
South Carolina vs Texas A&M Betting Lines
Iowa at USC -6.5
It’s easy to back Iowa after their gritty two-point loss to Oregon, but this spot sets up perfectly for the Trojans.
The Iowa Hawkeyes left everything on the field in Week 11. Now they travel west to face a USC Trojans team still chasing a College Football Playoff berth.
USC could easily be a one-loss team — their early-season collapse against Illinois still stings. The Trojans’ offense is far superior, and Iowa rarely elevates on the road.
Expect the Trojans to take care of business and cover at home.
Writer’s Week 12 Pick: USC -6.5 (Trojan Win & Cover)
D.S. Williamson’s Week 12 selections in the MyBookie Writers’ NCAAF Picks highlight key matchups, coaching edges, and momentum swings — offering bettors smart insight into college football betting odds, spreads, and best-value lines for Week 12.
Henry Watkins | MyBookie Sports Writer
Henry is originally from Scotland but now resides in Metro Atlanta with his chef wife Penny.
As well as working as a Sports freelance writer, he also writes horror fiction.
Watson is the author of Karaoke Night, Crueller, and Off The Grid.
🏈 NCAAF Week 12 Winning Picks
NCAAF Week 12 SU Picks
We have some big games coming this weekend, with Georgia and Texas as one of the highlights — and I have the Dawgs winning this one.
The West Virginia Mountaineers hit the road for their third away game in five weeks, so I like the Arizona State Sun Devils to take advantage of that with a home win.
The Texas A&M Aggies can move one step closer to an SEC Championship Game berth — and I think they do it with a comfortable win over South Carolina.
NCAAF Week 12 SU Picks
Georgia vs Texas – SU Pick: Georgia
West Virginia vs Arizona State – SU Pick: Arizona State
Texas A&M vs South Carolina – SU Pick: Texas A&M
Bet NCAAF Week 12 Odds
NCAAF Week 12 ATS Picks
Against the spread, I’m focusing on matchups where momentum and motivation align heading into Week 12.
The Michigan Wolverines still have an outside shot at reaching the Big Ten Championship Game, so look for them to roll Northwestern as 9½-point favorites.
The USF Bulls offense has been consistently strong all season long. While Navy will be tough, I like the Bulls -10½ to get it done.
To close things out, I’m grabbing an underdog — the Iowa Hawkeyes +6½ against USC looks like solid value. Iowa’s defense should keep this one tight.
NCAAF Week 12 ATS Picks
Michigan vs Northwestern – ATS Pick: Michigan -9.5
USF vs Navy – ATS Pick: USF -10.5
Iowa vs USC – ATS Pick: Iowa +6.5
Bet NCAAF Week 12 Lines
NCAAF Week 12 O/U Picks
Totals betting this week is all about tempo and game control, with several matchups showing clear value on the number.
I already have the Michigan Wolverines winning and covering, but I also think they’ll shut Northwestern down, keeping the total UNDER 41½.
We should see both the Notre Dame Fighting Irish and Pittsburgh Panthers rely heavily on their run games to dictate pace — I like the UNDER 55½.
On the flipside, expect fireworks when the Arizona Wildcats face the Cincinnati Bearcats, as both teams should combine to go OVER 56½.
NCAAF Week 12 O/U Picks
Michigan vs Northwestern – Pick: UNDER 41.5
Notre Dame vs Pittsburgh – Pick: UNDER 55.5
Arizona vs Cincinnati – Pick: OVER 56.5
Bet NCAAF Week 12 Totals
Henry Watkins’ Week 12 card in the MyBookie Writers’ NCAAF Picks delivers confident SU winners, sharp ATS angles, and smart totals plays — giving bettors top value heading into the late-season college football slate. Don’t miss your chance to grab the best NCAAF betting odds before the lines move.
Final Take: Bet Smart, Stay Sharp for College Football Week 11
Week 11 of the College Football season is packed with playoff implications, rivalry momentum, and sharp betting opportunities — the kind of edges that reward disciplined bettors.
With D.S. Williamson and Henry Watkins breaking down spreads, totals, and moneyline plays, you’ll have the expert insight needed to make smarter, data-driven wagers before kickoff.
Stay on top of injury reports, monitor live NCAAF odds, and lock in early — because the best numbers move fast once the public joins the action.
Skip the hype and trust the analytics. Read the lines, follow the momentum, and build your winning ticket with precision at MyBookie Sportsbook.
Bet the Best College Football Week 11 Lines with MyBookie
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Week 12 College Football Playoff Rankings pic.twitter.com/rrSu7sdQwl
— CFB Kings (@CFBKings) November 12, 2025
Check out our MyBookie Blast from the Past: 2023 NCAAF Season’s Week 11 Picture
2023 College Football Week 12 Betting Lines and Analysis
The College Football season runs from the end of August through the end of November.
The week starts on Tuesday with a threesome of MAC football games.
There are three games the rest of the week before the big action on Saturday.
Illinois Fighting Illini at Iowa Hawkeyes
Big Ten affair. Both teams feel they will be better this season.
North Carolina Tar Heels at Clemson Tigers
Dabo Swinney and his Clemson Tigers will be on guard as the Tar Heels come to town.
Georgia Bulldogs at Tennessee Volunteers
You never know what is going to happen when you get to Neyland Stadium in Knoxville.
Utah Utes at Arizona Wildcats
A game out West. The Pac-12 is going to be an interesting conference to watch because you never really know who to expect to be good out there.
Oklahoma Sooners at Brigham Young Cougars
The Sooners’ first trip to Provo, and maybe their last. Oklahoma is heading out of the Big 12, while Brigham Young is coming in.
Chattanooga Mocs at Alabama Crimson Tide
Bryant-Denny Stadium sees a nonconference team come to town. No way Nick Saban lets his guys look ahead, right?
Ready to lock in your play? Don’t wait until kickoff — grab the latest odds now.
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