College Football Week 11 Picks & Predictions | Expert NCAAF Betting Lines

Since 2008, D.S. Williamson has written about sports and sports handicapping.

His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to sportsbook odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.

Indiana -13.5 at Penn State

Before the season, many had Penn State beating Ohio State and dominating Indiana to secure a College Football Playoff spot as a top seed.

The Penn State Nittany Lions completely fell apart — James Franklin was dismissed, and the team has spiraled into one of the worst in the Big Ten.

The bad vibes should continue Saturday because the Indiana Hoosiers only know how to play one way: dominate both sides of the ball.

Indiana doesn’t play down to their competition, and their physicality should show early.

Expect a comfortable Hoosier cover on the road.

Writer’s Week 10 Pick: Indiana -13.5 (Confident Cover)

Indiana vs Penn State Betting Lines

Oregon -5.5 at Iowa

The Ducks rebounded from their loss to Indiana by blasting Rutgers and handling Wisconsin in a 21–7 win.

The Oregon Ducks now head to Iowa for a tricky road test against a Hawkeyes team that thrives on defense and crowd energy.

The Iowa Hawkeyes can make any high-powered offense look sluggish, especially in Kinnick Stadium.

Oregon remains the more talented team, but this spot sets up for a close one.

Take Iowa and the points at home.

Writer’s Week 10 Pick: Iowa +5.5 (Home Dog Play)

Oregon vs Iowa Betting Lines

BYU at Texas Tech -9.5

BYU has been red-hot, knocking off Iowa State 41–27 and edging Utah 24–21 in one of college football’s fiercest rivalries.

The BYU Cougars are playing with confidence and physicality on both sides of the ball.

The Texas Tech Red Raiders are the more talented roster on paper, but BYU’s toughness and momentum make them hard to fade.

Even in Lubbock, it’s tough to see the Cougars losing by double digits.

Grab the points and back the underdog to cover.

Writer’s Week 10 Pick: BYU +9.5 (Underdog Value)

BYU vs Texas Tech Betting Lines

LSU at Alabama -10.5

LSU versus Alabama remains one of college football’s most storied rivalries, but this year’s matchup looks one-sided.

The Alabama Crimson Tide have shown inconsistency at times, but their depth and defensive talent should shine here.

The LSU Tigers don’t have the weapons or rhythm to keep pace for four quarters against this Tide defense.

Expect Alabama to pull away by the second half and deliver a decisive victory in front of the home crowd.

The Tide roll by two touchdowns or more.

Writer’s Week 10 Pick: Alabama -10.5 (Roll Tide Cover)

LSU vs Alabama Betting Lines

D.S. Williamson’s Week 10 selections in the MyBookie Writers’ NCAAF Picks highlight team momentum, defensive mismatches, and situational edges — offering bettors fresh insights into college football betting odds, spreads, and moneyline plays before kickoff.

Henry is originally from Scotland but now resides in Metro Atlanta with his chef wife Penny.

As well as working as a Sports freelance writer, he also writes horror fiction.

Watson is the author of Karaoke Night, Crueller, and Off The Grid.

NCAAF Week 11 SU Picks

Building a winning parlay this weekend? For my straight-up (SU) selections, I’m locking in three confident plays that combine consistency, form, and matchup value.

The Ohio State Buckeyes look poised to roll through the Purdue Boilermakers — there’s just too much firepower on both sides of the ball for this to stay close.

In the SEC, I’m taking the Texas A&M Aggies to stay hot and keep their run alive with a win over the Missouri Tigers.

Finally, the Alabama Crimson Tide should keep LSU’s tough season going — expect the Tide to dominate at home.

NCAAF Week 11 SU Picks

Ohio State vs Purdue – SU Pick: Ohio State
Texas A&M vs Missouri – SU Pick: Texas A&M
Alabama vs LSU – SU Pick: Alabama
Bet NCAAF Week 11 Odds

NCAAF Week 11 ATS Picks

Against the spread (ATS), I’m zeroing in on matchups where recent performance and market pricing don’t align.

In the Big 12, the Texas Tech Red Raiders are favored by 10½ over BYU — and I like Tech to cover at home.

The Clemson Tigers have had a tough year, but they should get it done against Florida State as 2½-point favorites.

Finally, the Georgia Bulldogs have been slow starters but tend to close strong — I expect them to handle Mississippi State and cover the 7½-point spread.

NCAAF Week 11 ATS Picks

Texas Tech vs BYU – ATS Pick: Texas Tech -10.5
Clemson vs Florida State – ATS Pick: Clemson -2.5
Georgia vs Mississippi State – ATS Pick: Georgia -7.5
Bet NCAAF Week 11 Lines

NCAAF Week 11 O/U Picks

Totals betting this week comes down to offensive rhythm and defensive discipline — and a few matchups stand out for value.

Both the Indiana Hoosiers and Penn State Nittany Lions have struggled offensively, making UNDER 49½ the sharp side.

We’ll take another UNDER when the Oregon Ducks visit the Iowa Hawkeyes — both defenses can lock down and control tempo.

For the final pick, expect fireworks when the Notre Dame Fighting Irish meet the Navy Midshipmen — OVER 55½ looks like the right play.

NCAAF Week 11 O/U Picks

Indiana vs Penn State – Pick: UNDER 49.5
Oregon vs Iowa – Pick: UNDER 49
Notre Dame vs Navy – Pick: OVER 55.5
Bet NCAAF Week 11 Totals

Henry Watkins’ Week 11 card in the MyBookie Writers’ NCAAF Picks combines confident favorites, sharp underdog covers, and well-analyzed totals — offering bettors top value plays for spreads, SU bets, and O/U markets this college football weekend. Make sure to log in early and lock in the best NCAAF betting odds before the lines move.