NFL 2022 Preseason Week 4 Betting Analysis & Picks for the Top Games of the Week

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The NFL’s final preseason week this year could help us pad the bankroll heading into the regular season. On Thursday, the Chiefs host the Packers and the Texans welcome the 49ers. Then on Friday, Carolina quarterback Sam Darnold gets some work against the Bills while the Saints throw down versus the Chargers. Keep reading for NFL Preseason Odds, analysis, and free picks for six terrific NFL preseason matchups happening this Thursday and Friday.

2022 NFL Preseason Games to Bet On August 25th and 26th

2022 NFL Preseason Week 4

When: Thursday, August 25 – Sunday, August 26

Green Bay Packers -1.5 at Kansas City Chiefs | Thursday, August 25

The Green Bay Packers head to Kansas City knowing exactly what they want to accomplish. So do the Chiefs. The difference in this matchup is that Green Bay’s backup quarterback, Jordan Love, is likely to play better than Kansas City’s backup.

Then again, the Packers may keep Jordan on the bench. There’s no use playing Love because Matt LaFleur already knows his depth chart. KC is worth backing.

NFL Preseason Week 4 Pick: Kansas City Chiefs

San Francisco 49ers -3.5 at Houston Texans | Thursday, August 25

The odds don’t make a lot of sense. Trey Lance isn’t likely to play. Nor is Jimmy Garoppolo. The last thing the Niners want to do is hurt Jimmy G. and miss out on a possible trade.

At this point, San Francisco would take a fifth round pick before cutting Garoppolo. The Texans aren’t a great team and the bench is light on talent, but Houston can win at home.

NFL Preseason Week 4 Pick: Houston Texans

Buffalo Bills at Carolina Panthers -5.5 | Friday, August 26

The odds suggest what all of us know. The Panthers figure to play Sam Darnold for the entire game while the Bills throw in the third string.

Buffalo won’t take the chance of any injuries, zero, to their first string or even second string. Carolina should cover this spread.

NFL Preseason Week 4 Pick: Carolina Panthers

Seattle Seahawks -4 at Dallas Cowboys | Friday, August 26

The Cowboys will use the third NFL preseason game to get communication down and to make sure their second string and third string players are ready.

Seattle will play both Drew Lock and Geno Smith because Pete Carroll said the Seahawks may play with a couple of starting quarterbacks this season.

Don’t you have the feeling the Seattle mails it in this season? In any case, the Hawks cover this spread.

NFL Preseason Week 4 Pick: Seattle Seahawks

Los Angeles Chargers at New Orleans Saints -3 | Friday, August 26

The Chargers have no desire to play any of their starters. So the Bolts figure to rest the entire starting lineup on both sides of the ball and rest key second string players.

The Saints will do the same. The difference is that this happens in New Orleans and the Saints are deeper at most positions. New Orleans wins and covers.

NFL Preseason Week 4 Pick: New Orleans Saints

New England Patriots at Las Vegas Raiders -1.5 | Friday, August 26

Bill doesn’t push his team in any preseason game but he really lays off in the third contest. Belichick doesn’t care that former offensive coordinator Josh McDaniels coaches the Raiders.

He won’t try to win this game. The Raiders grab the victory and cover by default.

NFL Preseason Week 4 Pick: Las Vegas Raiders

I have read enough, I need to place my bet now. What to do?