Top NFL San Francisco 49ers Games to Bet On the Upcoming 2022-23 Season

Top NFL San Francisco 49ers Games to Bet On the Upcoming 2022-23 Season

San Francisco head coach Kyle Shanahan has committed to Trey Lance. Shanahan believed Lance is the 49ers’ best chance to win Super Bowl 57. Because the Niners are committed to the former North Dakota State quarterback, it’s a matter of time before Jimmy Garoppolo finds a new address. Check out eight San Francisco games to circle on your NFL Betting calendar. We add more info about each game knowing Lance is the starter at quarterback. 

2022 San Francisco 49ers Must Bet Games During the Regular Season | NFL Betting Picks

2022-23 NFL Regular Season

  • When: Sep. 8, 2022 – Jan. 8, 2023

San Francisco vs Seattle | Week 2 – Sunday, Sep. 18

Trey Lance is 6’ 4” and 224 pounds. He’s got wheels even though he’s not all that fast. Lance will be more of a pocket passing quarterback, which means he should have no trouble sitting in the pocket, rolling out if he must, evading the rush if he must, etc.

Versus Seattle, all of Lance’s skills will be on display. San Francisco should blow out the rebuilding Seahawks. SF will roll to a 20 to 30 points victory because the Seahawks’ offense won’t move the ball versus San Francisco’s defense. 

San Francisco vs L.A. Rams | Week 4 – Monday, Oct. 3

The 49ers should make a statement. The Rams remain the team to beat in the NFC West, but Matthew Stafford is a season older while Trey Lance is just getting started.

The Rams’ defense won’t benefit from having Von Miller playing in a 3-4 with Aaron Donald. Expect the 49ers to win this by at least a touchdown. 

San Francisco vs Kansas City Chiefs | Week 7 – Sunday, Oct. 23

By NFL Week 7, both the 49ers and Chiefs should have terrific records. Trey Lance versus Patrick Mahomes should be electric. Lance has Mahomes like skills.

But the 49ers could be overplayed because this happens at Levi’s Stadium. The Chiefs will have a shot for the moneyline win. KC should at least cover the spread. 

San Francisco at Los Angeles Rams | Week 8 – Sunday, Oct. 30

In the second game, San Francisco takes on the Rams at SoFi Stadium. Los Angeles should exact their revenge in the rematch.

The Rams and 49ers will battle each other all season for the NFC West title. We shouldn’t expect the Rams to lie down in the rematch. An LAR revenge victory and cover is more than probable.

San Francisco vs Tampa Bay | Week 14 – Sunday, Dec. 11

Tampa Bay heads to San Francisco to take on the 49ers. By NFL Week 14, the Buccaneers will either be a top NFC squad or an okay team.

Either way, the 49ers will win this game. Trey Lance will have developed into a legit QB1 by NFL Week 14. San Francisco will expose Tampa’s awful pass defense. 49ers win and cover. 

San Francisco at Seattle | Week 15 – Thursday, Dec. 15

Sometimes, it’s good to go with what’s obvious. The Seattle Seahawks won’t be close to San Francisco’s level. The 49ers should dominate the Seahawks on both sides of the ball. An SF win and cover will be a sure thing. 

San Francisco vs Washington | Week 16 – Saturday, Dec. 24

Washington won’t have much chance versus the 49ers. If San Francisco is as good as they project, the Commanders will struggle to move the ball against the Nick Bosa led defense and the offense will blast Washington’s D. Another win and cover for SF is more than probable. 

San Francisco vs Arizona | Week 18 – Sunday, Jan. 8

Arizona shouldn’t have as good of a team this season as they did last season. DeAndre Hopkins will be back by NFL Week 18, but the Cardinals may not have much to play for. 

San Francisco almost certainly will. SF should end their season with a huge win and cover.  


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