Best 2022 NFL Week 5 Games to Bet On, Early Analysis, and Picks

This season, every week in the NFL shows excellent matchups. NFL Week 5 is no different. Things start off with one of the more important games of the season when the Indianapolis Colts travel to Denver to take on the Broncos. Sunday’s top matchup is an AFC North throw down when the Ravens host the Bengals. Then on Monday night, AFC West rivals Las Vegas and KC clash in Kansas City. Check out a NFL Betting analysis and a way too early pick for games happening in NFL Week 5.  

Must Bet Games in Week 5 of the 2022-23 NFL Season

2022 NFL Week 5

  • When: Thursday, Oct. 6 – Monday, Oct. 10

Indianapolis Colts at Denver Broncos | Thursday, Oct. 6

Denver should have no trouble beating and covering against the Colts. Indianapolis is a solid squad, but the jury is out on how much football Matt Ryan has left to play.

Russell Wilson is in his prime. The Broncos should handle the Colts no problem. 

NFL Week 5 Pick: Denver Broncos  

New York Giants at Green Bay Packers | Sunday, Oct. 9

The Packers should be the chalk, but before dumping on Aaron Rodgers and his teammates, it’s important to note the improvements the Giants have made. 

NYG’s defense could end up one of the better units in the NFL. If Saquon Barkley is one-hundred percent, he’ll be a difference maker this season. 

NFL Week 5 Pick: New York Giants 

Los Angeles Chargers at Cleveland Browns | Sunday, Oct. 9

There’s a good chance Deshaun Watson remains suspended through week 5, which means backup quarterback Jacoby Brissett will have to lead the Browns offense against what projects to be one of the best defenses in the league. 

The Bolts offense should also be in the top five. For the Chargers to take the next step, they must win road games versus teams like Cleveland. Bolts take this. 

NFL Week 5 Pick: Los Angeles Chargers 

Dallas Cowboys at Los Angeles Rams | Sunday, Oct. 9

Although it happens early, Cowboys versus Rams could determine NFC Playoff seeding. The Rams will be a good team. 

But the Cowboys should be better. Dallas’ offense should do enough to keep Aaron Donald and his mates on their toes. Not only that, but the Cowboys’ defense can shut down L.A.’s offense. 

NFL Week 5 Pick: Dallas Cowboys 

Philadelphia Eagles at Arizona Cardinals | Sunday, Oct. 9

Unless Jalen Hurts doesn’t improve at all, he figures to carve up the Cardinals’ defense. Arizona should also have trouble on offense.

Kyler Murray will struggle as long as DeAndre Hopkins remains out due to a suspension. The Cardinals face a tough first five weeks of the NFL season. Philly figures to add to Zona’s woes. 

NFL Week 5 Pick: Philadelphia Eagles 

Cincinnati Bengals at Baltimore Ravens | Sunday, Oct. 9

The top two projected teams in the AFC North are the Baltimore Ravens and Cincinnati Bengals. Both teams are good enough to win the division.

But Joe Burrow plays for just one of the two squads. Burrow to Ja’Marr Chase will be even better in 2022. This season, Cincy is searching for a Super Bowl. Baltimore hopes to get back to the playoffs. This should be an epic battle that ends with a Cincinnati victory. 

NFL Week 5 Pick: Cincinnati Bengals  

Las Vegas Raiders at Kansas City Chiefs | Monday, Oct. 10

Every AFC West division game will mean something this season. Yes, even Raiders at Chiefs. Beating Patrick Mahomes and the Chiefs in Kansas City is tough.

But the Raiders can do it. Josh McDaniels will devise a strategy to keep Mahomes on the bench. Carr to Adams will have gelled by NFL Week 5. Raiders can pull off the upset win. 

NFL Week 5 Pick: Las Vegas Raiders  


I have read enough, I need to place my bet now. What to do?

Bet NFL Today
MyBookie Betting Lines for the Game


NFL Betting Center

NFL MyBookie Odds | Online Betting Lines