College Football Week 10 Picks & Odds

College Football Week 10 is here — and sharp bettors know the value window is shrinking fast as lines tighten, injuries pile up, and playoff pressure hits full swing.

Every Saturday matters now in the College Football Playoff chase, and smart college football bettors are jumping on the best sportsbook lines before they move.

At MyBookie Sportsbook, our expert analyst D.S. Williamson breaks down his College Football Week 10 picks — spotlighting momentum shifts, injury updates, and betting angles that deliver true ATS and moneyline value across the weekend slate.

MyBookie Writers’ College Football Week 10 Picks & Predictions

This week’s lineup brings everything from Big Ten bounce-backs to SEC upsets in the making — with betting opportunities on every board.

Featured matchups include Vanderbilt at Texas, Michigan State at Minnesota, Indiana at Maryland, and Duke at Clemson — all prime games to target in your college football parlays and live betting odds.

Whether you’re placing a quick bet on mobile or building a Saturday parlay, MyBookie gives you everything you need — from early lines and prop bets to real-time live odds and fast payouts.

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D.S. Williamson’s College Football Week 10 Expert Predictions

Let’s dive into this week’s slate of value-driven college football picks — where the sharpest money is going, and which underdogs have a shot to cash.

D.S. Williamson | MyBookie Sports Writer

Since 2008, D.S. Williamson has written about sports and sports handicapping.

His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to sportsbook odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.

Vanderbilt +110 at Texas

Can the Vanderbilt Commodores pull off another upset?

They just might. The Commodores hosted Missouri in their last game in what many believed would be a high-scoring affair. Instead, it turned into a 17-10 defensive slugfest that Vanderbilt won.

The Dores proved they could take down solid opponents with defense and grit. Texas lost Arch Manning for who knows how long while barely rallying to beat Mississippi State in overtime.

Vanderbilt is playing more complete football right now and should handle the Horns straight up.

Michigan State at Minnesota -4.5

Don’t be fooled by the Gophers’ last outing — this team bounces back.

Iowa absolutely dominated Minnesota in the Gophers’ last game, pounding them 41-3.

But before jumping on Michigan State, we need to consider the context — Minnesota was on the road facing a sneaky-good Iowa defense that just held Indiana to 20 points in a close loss.

Michigan State is still one of the weaker teams in the Big Ten. Expect the Gophers to rebound in a big way and cover the 4.5 at home.

Indiana -23.5 at Maryland

The Indiana Hoosiers keep proving why they’re the most complete squad in college football.

Last week, Indiana didn’t play down to their competition. Facing a UCLA team riding three straight wins, the Hoosiers dominated by 50 points.

Maryland already lost to UCLA a couple of weeks ago — and Indiana handled those same Bruins with ease.

This one could get ugly fast. The Hoosiers don’t take Saturdays off. Expect another blowout cover from the Big Ten’s most complete team.

Duke +122 at Clemson

It’s officially meltdown mode for Clemson.

The Tigers sit at 3-4 and look completely lost. Dabo Swinney’s grip on the program has slipped since the NIL era began. Earlier this year, he was talking about an undefeated season — now, he’s losing home games to Syracuse and SMU.

The Duke Blue Devils are disciplined, confident, and trending up. Jump on this moneyline before the odds move — Duke should do enough to continue Clemson’s 2025 nightmare.

D.S. Williamson Week 10 Picks

Vanderbilt +110 at Texas – Bet: Vanderbilt Moneyline
Michigan State at Minnesota -4.5 – Bet: Minnesota -4.5
Indiana -23.5 at Maryland – Bet: Indiana -23.5
Duke +122 at Clemson – Bet: Duke Moneyline
College Football Lines

D.S. Williamson’s Week 10 selections in the MyBookie Writers’ College Football Picks zero in on momentum shifts, injury impact, and undervalued programs — offering sharp insights for bettors ready to capitalize on mispriced college football betting odds and uncover premium ATS and moneyline opportunities before Saturday’s action kicks off.

Final Thoughts: Bet Smarter on College Football Week 10

Week 10 is packed with everything sharp bettors look for — upset alerts, bounce-back spots, and hidden line value before Saturday’s kickoffs.

From Vanderbilt vs Texas and Duke vs Clemson to Indiana’s Big Ten dominance, every matchup offers a chance to find edges against the spread and in live markets. Whether you’re betting spreads, totals, or moneylines, MyBookie Sportsbook delivers real-time live betting odds, player props, and fast payouts for every wager.

D.S. Williamson has delivered his best value picks — now it’s your turn to make your move.

Get in early, grab the best numbers, and build your winning ticket before the lines shift.